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Gene editing therapeutics based on mRNA delivery
Advanced Drug Delivery Reviews, 2023The field of gene editing has received much attention in recent years due to its immense therapeutic potential. In particular, gene editing therapeutics, such as the CRISPR-Cas systems, base editors, and other emerging gene editors, offer the opportunity to address previously untreatable disorders.
Juliana, Popovitz +5 more
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Unlocking Delivery Strategies for mRNA Therapeutics
Recent Patents on Anti-Cancer Drug DiscoveryAbstract: mRNA emerged as an attractive therapy modality with the development of mRNA structure engineering techniques and delivery platforms. mRNA therapeutics, applied for vaccine therapy, protein replacement therapy, and chimeric antigen receptor (CAR) T cell-based therapy, has shown huge potential in treating a wide range of diseases, such as ...
Zhiyuan, Luo, Yangchao, Chen
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Advances in Development of mRNA-Based Therapeutics
2020Recently, mRNA-based therapeutics have been greatly boosted since the development of novel technologies of both mRNA synthesis and delivery system. Promising results were showed in both preclinical and clinical studies in the field of cancer vaccine, tumor immunotherapy, infectious disease prevention and protein replacement therapy. Recent advancements
Lei, Huang +6 more
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Therapeutic mRNA vaccine applications in oncology
Molecular TherapyThe emergence of mRNA vaccines for infectious diseases has heralded development for a slew of other indications including cancer. Lipid particle delivery vehicles can protect RNA from degradation and promote delivery to intended targets in vivo. In this mini-review, we discuss mRNA vaccine mechanisms and capacity for enhancement followed by progress to
Leighton Elliott +4 more
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Clinical development of therapeutic mRNA applications
Molecular TherapymRNA therapeutics are emerging as a transformative approach in modern medicine, providing innovative, highly adaptable solutions for a wide range of diseases, from viral infections to cancer. Since the approval of the first mRNA therapeutic-the coronavirus disease 2019 vaccines in 2021-we have identified more than 70 current clinical trials utilizing ...
Magdalena M. Żak, Lior Zangi
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mRNA therapeutics deliver a hopeful message
Nano Today, 2018Abstract Messenger RNA based therapeutics have the potential to cause a big revolution in medicine as they can facilitate personalized medicines and allow patients to produce their own therapeutic proteins without the current purification, solubility and inappropriate glycosylation issues associated with recombinant therapeutic proteins.
Zifu Zhong +8 more
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Unlock the sustained therapeutic efficacy of mRNA
Journal of Controlled ReleasemRNA therapies have emerged as a transformative class of medicines, offering immense potential across a diverse array of applications. This progress has been particularly evident in the wake of the success of lipid nanoparticle (LNP)-based mRNA vaccines during the COVID-19 pandemic.
Dinglingge, Cao +7 more
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