Results 21 to 30 of about 287,741 (287)
Future Impact of mRNA Therapy on Cardiovascular Diseases
Methodist DeBakey Cardiovascular Journal, 2022 The silver lining of the recent pandemic was that it accelerated the emergence of messenger ribonucleic acid (mRNA) therapeutics. The great promise of mRNA therapeutics was highlighted by the speed at which the vaccines were created, tested, and proven ...
John P. Cooke, Keith A. Youker
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Pharmaceutics, 2021 Messenger RNA (mRNA) delivery strategies are required to protect biologically fragile mRNA from ribonuclease (RNase) attacks to achieve efficient therapeutic protein expression.
Naoto Yoshinaga +6 more
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mRNA vaccine: a potential therapeutic strategy [PDF]
Molecular Cancer, 2021 AbstractmRNA vaccines have tremendous potential to fight against cancer and viral diseases due to superiorities in safety, efficacy and industrial production. In recent decades, we have witnessed the development of different kinds of mRNAs by sequence optimization to overcome the disadvantage of excessive mRNA immunogenicity, instability and ...
Yang Wang +5 more
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Fluorescence-based quantification of messenger RNA and plasmid DNA decay kinetics in extracellular biological fluids and cell extracts [PDF]
, 2020 Extracellular and intracellular degradation of nucleic acids remains an issue in non-viral gene therapy. Understanding biodegradation is critical for the rational design of gene therapeutics in order to maintain stability and functionality at the target ...
Braeckmans, Kevin +6 more
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Emerging Therapeutics Targeting mRNA Translation [PDF]
Cold Spring Harbor Perspectives in Biology, 2012 A defining feature of many cancers is deregulated translational control. Typically, this occurs at the level of recruitment of the 40S ribosomes to the 5'-cap of cellular messenger RNAs (mRNAs), the rate-limiting step of protein synthesis, which is controlled by the heterotrimeric eukaryotic initiation complex eIF4F.
Abba, Malina +2 more
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Applications and challenges of biomaterial mediated mRNA delivery
Exploration of Targeted Anti-tumor Therapy, 2022 With the rapid development of gene therapy technology and the outbreak of coronavirus disease 2019 (COVID-19), messenger RNA (mRNA) therapeutics have attracted more and more attention, and the COVID-19 mRNA vaccine has been approved by the Food and Drug ...
Huapan Fang, Qian Chen
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Pharmaceutics, 2023 mRNA-based therapeutics are presently one of the nucleic acid-based therapeutics with a high potential for extraordinary success as preventive vaccines.
Ly Porosk +5 more
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Recent advances in mRNA-LNP therapeutics: immunological and pharmacological aspects
Journal of Nanobiotechnology, 2022 In the last decade, the development of messenger RNA (mRNA) therapeutics by lipid nanoparticles (LNP) leads to facilitate clinical trial recruitment, which improves the efficacy of treatment modality to a large extent. Although mRNA-LNP vaccine platforms
Seyed Hossein Kiaie +6 more
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RNA interference approaches for treatment of HIV-1 infection. [PDF]
, 2015 HIV/AIDS is a chronic and debilitating disease that cannot be cured with current antiretroviral drugs. While combinatorial antiretroviral therapy (cART) can potently suppress HIV-1 replication and delay the onset of AIDS, viral mutagenesis often leads to
Bobbin, Maggie L +2 more
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Circular mRNA: A novel therapeutic agent
Biotechnology Notes, 2023 Circular mRNA (circmRNA) is a covalent closed loop formed by reverse splicing of the 3' end to the 5' end of mRNA. Compared to traditional linear mRNAs, circmRNAs can mediate efficient, stable, and durable protein expression and are considered an alternative to linear mRNAs in terms of therapeutic reagents.
Wang, Xiaoxue, Dong, Jian, Lu, Yuan
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