Results 71 to 80 of about 287,741 (287)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Nanomaterials for mRNA‐based therapeutics: Challenges and opportunities
Bioengineering & Translational Medicine, 2023 Messenger RNA (mRNA) holds great potential in developing immunotherapy, protein replacement, and genome editing. In general, mRNA does not have the risk of being incorporated into the host genome and does not need to enter the nucleus for transfection ...
De‐feng Li +10 more
doaj +1 more source
Transient but not genetic loss of miR-451 attenuates the development of pulmonary arterial hypertension [PDF]
, 2013 <b>Rationale:</b> MicroRNAs are small non-coding RNAs involved in the regulation of gene expression and have recently been implicated in the development of pulmonary arterial hypertension (PAH).
Baker, Andrew H. +5 more
core +2 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Current landscape of mRNA technologies and delivery systems for new modality therapeutics
Journal of Biomedical ScienceRealizing the immense clinical potential of mRNA-based drugs will require continued development of methods to safely deliver the bioactive agents with high efficiency and without triggering side effects.
Ruei-Min Lu +13 more
doaj +1 more source
Mutated TP53 is a marker of increased VEGF expression: analysis of 7,525 pan-cancer tissues. [PDF]
, 2020 Anti-angiogenic therapies are an important class of anti-cancer treatment drugs. However, their efficacy is limited to certain tumors and would benefit from identifying a biomarker predictive of therapeutic response.
Boichard, Amélie +2 more
core
pH-Sensitive Chitosan–Heparin Nanoparticles for Effective Delivery of Genetic Drugs into Epithelial Cells [PDF]
, 2019 Chitosan has been extensively studied as a genetic drug delivery platform. However, its efficiency is limited by the strength of DNA and RNA binding.
Korzhikov-Vlakh, Viktor +7 more
core +1 more source
Export of miRNAs from activated macrophages is cooperative and HuR‐dependent
FEBS Letters, EarlyView.This study uncovers a new mechanism for miRNA export regulation in mammalian cells, driven by the RNA‐binding protein HuR. In macrophages, HuR cooperatively binds with miRNAs to export both low‐ and high‐affinity substrates, thereby influencing macrophage activation.
Syamantak Ghosh +2 more
wiley +1 more source
The mRNA-Based Innovative Strategy: Progress and Challenges
Nano-Micro LettersHighlights Messenger ribonucleic acid (mRNA) structural optimization and delivery systems were comprehensively summarized. Current mRNA applications were thoroughly introduced.
Huayuan Zhou +10 more
doaj +1 more source
CleanCap M6 inhibits decapping of exogenously delivered IVT mRNA
Molecular Therapy: Nucleic AcidsCo-transcriptional capping allows exogenous mRNAs to yield robust protein expression. Identifying additional mRNA modifications that further boost protein output will be crucial for developing more efficacious mRNA therapies.
Zachary F. Mandell +13 more
doaj +1 more source