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Potential Relationship between Poor Oral Hygiene and MRONJ: An Observational Retrospective Study [PDF]
Medication-related osteonecrosis of the jaw (MRONJ) is a drug-related side effect linked but not limited to antiresorptive and antiangiogenic molecules. It recognizes several triggers in dental procedures, such as surgery, endodontic treatments, and root
Marco Dolci +2 more
exaly +2 more sources
An increasing number of patients with medication-related osteonecrosis of the jaws (MRONJ) has recently been reported. It is still being debated whether the presence or placement of dental implants can lead to MRONJ, so the aim of this study was to find ...
Natasha M Appelman-Dijkstra +1 more
exaly +2 more sources
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Denosumab: a case of MRONJ with resolution
British Dental Journal, 2016A patient was referred by a clinical oncologist regarding a non-healing area of bone in the lower jaw. The patient was taking denosumab (Prolia(®), Xgeva(®)) when they had a tooth extracted and the area failed to heal. Following suspension of the drug, the area healed with mucosal coverage.
C V, Lyttle, H, Patterson
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Bisphosphonate application and volumetric effects on MRONJ lesions
Journal of Cranio-Maxillofacial Surgery, 2021The purpose of this investigation was to analyze the volume of medication-related osteonecrosis of the jaw (MRONJ) lesions by semi-automatic segmentation of cone-beam computed tomography images, and correlate the results with the underlying diseases and applied medication.
Max-Philipp, Lentzen +6 more
openaire +2 more sources
Update MRONJ and perspectives of its treatment
Journal of Stomatology, Oral and Maxillofacial Surgery, 2017Antiresorptive agents are widely used in catabolic bone diseases. Not only bisphosphonates but also new drugs like Denosumab may induce osteonecrosis of the jaw as a side effect. The present review describes the current effect mechanisms of commonly used antiresorptives, pathogenetic theories for the development of antiresorptive-related osteonecrosis ...
Voss, Pit Jacob +4 more
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Çenelerin İlaca Bağlı Osteonekrozu (MRONJ)
2023İlaçla ilişkili çene osteonekrozu (MRONJ), bazı ilaçların nadir görülen fakat oldukça ciddi bir yan etkisidir. Bu ilaçlardan en yaygın bilineni bifosfonatlar olsa da biyolojik antirezorptifler, antianjiyojenikler ve immünmodülatörler de MRONJ etiyopatolojisinde yer tutmaktadır.
Ahsen Öztürk +2 more
openaire +1 more source
Macrophage Polarization during MRONJ Development in Mice
Journal of Dental ResearchMacrophages are important regulators of bone remodeling, and M1 polarization is observed in the setting of medication-related osteonecrosis of the jaws (MRONJ). Here, we characterize the phenotype of macrophages during early stages of MRONJ development in zoledronate (ZA)–treated mice with periodontal disease and explore the role of rosiglitazone, a ...
A. Soundia +7 more
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Case report of a spontaneous occurrence of MRONJ
Journal of the Irish Dental Association, 2020Medicine-related osteonecrosis of the jaws can occur spontaneously and not just after dental procedures. This case report chronicles the management of a lesion of MRONJ.
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