Results 81 to 90 of about 111,528 (283)

Interaction of Fibrinogen and Muramidase-released Protein Promotes the Development of Streptococcus suis Meningitis

open access: yesFrontiers in Microbiology, 2015
Muramidase-released protein (MRP) is as an important virulence marker of Streptococcus suis (S. suis) serotype 2. Our previous works have shown that MRP can bind human fibrinogen (hFg); however, the function of this interaction in S.suis meningitis is ...
Junping eWang   +7 more
doaj   +1 more source

Enhancing Selective Brain Cancer Therapy: Integrating Nanomedicine and Molecular Dynamics to Target the Cancerous Lipid Composition

open access: yesNano Select, EarlyView.
Improving selectivity within therapeutic design is critical to ensure targeted delivery to brain tumors. Targeting the cellular membrane composition distinctive of the blood–brain barrier and brain cancer cells is explored in this review. Nanomedicine can be utilized for precise tumor recognition, and detailed mechanistic interactions of therapeutics ...
Mahnoor Kadri   +2 more
wiley   +1 more source

Scalar self-energy for a charged particle in global monopole spacetime with a spherical boundary

open access: yes, 2012
We analyze combined effects of the geometry produced by global monopole and a concentric spherical boundary on the self-energy of a point-like scalar charged test particle at rest. We assume that the boundary is outside the monopole's core with a general
de Mello, E. R. Bezerra, Saharian, A. A.
core   +1 more source

Multidrug Resistance Protein (MRP)-mediated Transport of Leukotriene C and Chemotherapeutic Agents in Membrane Vesicles

open access: yesJournal of Biological Chemistry, 1996
The 190-kDa multidrug resistance protein (MRP) has recently been associated with the transport of cysteinyl leukotrienes and several glutathione (GSH) S-conjugates.
D. W. Loe   +3 more
semanticscholar   +1 more source

The ketogenic diet alters microbiome‐metabolome profiles to improve West syndrome therapy

open access: yesPediatric Investigation, EarlyView.
The ketogenic diet alleviates West syndrome by reshaping gut microbiota (increasing Bacteroides, Parabacteroides, and reducing Escherichia and Bifidobacterium), and modulating metabolites—including anticonvulsant lipids (e.g., capric acid), suppressed harmful lipids (e.g., 2‐methylbutyroylcarnitine), and amino acids and analogs (e.g., 3‐sulfinoalanine)—
Gan Xie   +5 more
wiley   +1 more source

Reform and Representation: A New Method Applied to Recent Electoral Changes [PDF]

open access: yes, 2016
Can electoral reforms such as an independent redistricting commission and the top-two primary create conditions that lead to better legislative representation?
Kousser, T, Phillips, J, Shor, B
core   +3 more sources

A Growth Chart for KBG Syndrome

open access: yes
American Journal of Medical Genetics Part A, EarlyView.
Karen J. Low   +6 more
wiley   +1 more source

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo   +5 more
wiley   +1 more source

Hedging and Standard — MRP [PDF]

open access: yes, 1988
In standard-MRP packages it is possible to use safety stocknorms. In none of the standard-MRP packages however, it is possible to use hedging as an alternative technique for safety stocknorras, although this technique has several advantages from a theoretical point of view. At Eindhoven University of Technology an attempt is made to incorporate hedging
Donselaar, van, K., Wijngaard, J.
openaire   +2 more sources

New Hybrid Nanocomposite Films for Optical Diagnostics and Optical Temperature Sensing: Synergy Among α‐Synuclein, Gold and Upconverting Nanoparticles

open access: yesSmall, EarlyView.
Gold and upconverting nanoparticles coated with alpha‐synuclein were exploited to produce a quasi‐monolayer hybrid film. The film was then characterized, and its behaviour as a primary optical nano‐thermometer was studied. The film was also used in a proof‐of‐concept study of image‐based optical nanothermometry exploiting a home‐built up‐conversion ...
Emil Milan   +6 more
wiley   +1 more source

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