Results 131 to 140 of about 42,200 (256)

Next-generation sequencing of prostate cancer: genomic and pathway alterations, potential actionability patterns, and relative rate of use of clinical-grade testing. [PDF]

, 2019
Despite being one of the most common cancers, treatment options for prostate cancer are limited. Novel approaches for advanced disease are needed. We evaluated the relative rate of use of clinical-grade next generation sequencing (NGS) in prostate cancer,
Carter, Jennifer L, Elkin, Sheryl K, Ikeda, Sadakatsu, Kurzrock, Razelle, Tomson, Brett N   +4 more
core  

Blurring the Lines: Co‐Occurrence of MSH6 Variant and MLH1 Constitutional Epimutation in a Young Colorectal Cancer Patient

Clinical Genetics, Volume 109, Issue 2, Page 363-367, February 2026.
We report a unique case of early‐onset colorectal cancer with both a germline MSH6 variant and constitutional mosaic MLH1 epimutation, revealing a possible digenic mechanism underlying Lynch syndrome. This case highlights the diagnostic complexity of mismatch repair deficiency and the value of integrative tumor–germline molecular profiling.
Aasem Abu Shtaya, Yarin Hadid, Ahmad Mahamid, Debora Kidron, Naama Halpern, Adel Shalata, Zohar Levi, Yael Goldberg   +7 more
wiley   +1 more source

Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions

Nature Communications, 2016
DNA-binding proteins need to scan the genome to find their targets though how this occurs in the crowded nuclear environment is poorly understood. Here the authors use single-molecular fluorescence to show the repair complex Msh2-Msh3 can hop over blocks
Maxwell W. Brown, Yoori Kim, Gregory M. Williams, John D. Huck, Jennifer A. Surtees, Ilya J. Finkelstein   +5 more
doaj   +1 more source

DNA Polymerases as Potential Therapeutic Targets for Cancers Deficient in the DNA Mismatch Repair Proteins MSH2 or MLH1 [PDF]

, 2010
Sarah A. Martin, Nuala McCabe, Michelle J Mullarkey, Robert Cummins, Darren J. Burgess, Yusaku Nakabeppu, Sugako Oka, Elaine W. Kay, Christopher J. Lord, Alan Ashworth   +9 more
openalex   +1 more source

MSH2 is not required for either maintenance of DNA methylation or repeat contraction at the FMR1 locus in fragile X syndrome or the FXN locus in Friedreich’s ataxia

Epigenetics & Chromatin
Background Repeat-induced epigenetic changes are observed in many repeat expansion disorders (REDs). These changes result in transcriptional deficits and/or silencing of the associated gene.
Jessalyn Grant-Bier, Kathryn Ruppert, Bruce Hayward, Karen Usdin, Daman Kumari   +4 more
doaj   +1 more source

Frequency of Rearrangements in Lynch Syndrome Cases Associated with MSH2 : Characterization of a New Deletion Involving both EPCAM and the 5′ Part of MSH2 [PDF]

, 2011
Lucía Pérez‐Cabornero, Mar Infante, Eladio A. Velasco, Enrique Lastra Aras, Alberto Acedo, Cristina Miner Pino, M. Durán   +6 more
openalex   +1 more source

Supplementary Table 3 from Gene Conversion Is a Frequent Mechanism of Inactivation of the Wild-Type Allele in Cancers from <i>MLH1/MSH2</i> Deletion Carriers

, 2023
Jian Zhang, Annette Lindroos, Saara Ollila, Anna Russell, Giancarlo Marra, Hansjakob Mueller, Païvi Peltomäki, Martina Plášilová, Karl Heinimann   +8 more
openalex   +1 more source

Functional Characterization of MutS Homologue Mismatch Repair Proteins and their Variants [PDF]

, 2012
Lynch syndrome (LS) is one of the most common hereditary cancer syndromes and may lead to cancer development, mainly in colon or in endometrium, for 20 years earlier than in general population. LS is an autosomal dominantly inherited disorder, associated
Kantelinen, Jukka Petteri
core  

DNA Mismatch Repair in Plants (An Arabidopsis thaliana Gene That Predicts a Protein Belonging to the MSH2 Subfamily of Eukaryotic MutS Homologs) [PDF]

, 1997
Kevin M. Culligan, J B Hays
openalex   +1 more source

A new subtype of Lynch syndrome associated with MSH2 c.354T>A (p. Y118*) identified in a Chinese family: case report and literature review

Frontiers in Genetics
BackgroundLynch syndrome (LS) is an autosomal dominant inherited disorder caused by mutations in mismatch repair genes. Genetic counseling is crucial for the prevention and treatment of LS, as individuals with these mutations have an increased lifetime ...
Lan Zhong, Lan Zhong, Wenxiang Wang, Wenxiang Wang, Wenxiang Wang, Yuanqiong Duan, Yuanqiong Duan, Liang Song, Liang Song, Zhanghuan Li, Kaixuan Yang, Qintong Li, Rutie Yin, Rutie Yin   +13 more
doaj   +1 more source