Results 71 to 80 of about 29,501 (185)

Ploidy‐Dependent Response to Anticancer Drugs of Human Embryonic Stem Cells

Cell Proliferation, EarlyView.
Using isogenic hESCs, differing only in their ploidy level, we show the effect of ploidy on the resistance to anticancer drugs. We demonstrate that polyploidy, by itself, confers sensitivity to chemotherapies, leading to higher apoptosis and delayed proliferation, while the loss of p53 reverses the phenotype, demonstrating higher resistance.
Guy Haim‐Abadi, Nissim Benvenisty
wiley   +1 more source

Msh2 deficiency increases susceptibility to benzo[a]pyrene-induced lymphomagenesis

, 2006
DNA mismatch repair (MMR) is essential for repair of single-base mismatches and insertion/deletion loops. MMR proteins also participate in cellular response to DNA damaging agents such as various alkylating agents.
Ryberg, David, Phillips, David H, Eilertsen, Einar, Haugen, Aage, Svendsrud, Debbie H, te Riele, Hein, Zienolddiny, Shanbeh, Hewer, Alan, Skaug, Vidar   +8 more
core   +1 more source

Identification of Exo1-Msh2 interaction motifs in DNA mismatch repair and new Msh2-binding partners [PDF]

, 2018
Eukaryotic DNA mismatch repair (MMR) involves both exonuclease 1 (Exo1)-dependent and Exo1-independent pathways. We found that the unstructured C-terminal domain of Saccharomyces cerevisiae Exo1 contains two MutS homolog 2 (Msh2)-interacting peptide ...
William J. Graham, Christine M. Rahal, Bin-Zhong Li, Putnam, Christopher D, Christopher D. Putnam, Richard D. Kolodner, Goellner, Eva M, Graham, William J, Eva M. Goellner, Kolodner, Richard D, Rahal, Christine M, Li, Bin-Zhong   +11 more
core   +1 more source

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

Supp Fig S3 from MSH2 Loss in Primary Prostate Cancer

, 2017
Additional immunostains of the mismatch repair proteins in a formalin fixed and paraffin embedded primary prostate tumor with germline and somatic MSH2 loss from Figure 1.
William B. Isaacs (80210), Fawaz Almutairi (6718736), Mario A. Eisenberger (14997317), Jonathan I. Epstein (14317593), James R. Eshleman (14989454), Liana B. Guedes (15001544), Emmanuel S. Antonarakis (12643308), Colin C. Pritchard (14988971), Nooshin Mirkheshti (15003480), Jessica Hicks (252563), Tamara L. Lotan (14917692), Michael T. Schweizer (5328647), Jong Chul Park (15002381), Angelo M. De Marzo (11054067), Stephanie Glavaris (843058)   +14 more
core   +1 more source

Molecular analysis of three DNA mismatch repair protein variants in Chinese families with suspected Lynch syndrome

Frontiers in Medicine
PurposeThis study aimed to examine pathogenic variations in three families clinically diagnosed with suspected Lynch syndrome (LS).MethodsThree probands clinically diagnosed suspected LS were subjected to immunohistochemical analysis of DNA mismatch ...
Juyi Li, Haichun Ni, Peng Cheng, Yujia Peng, Lei Liu, Xiangyang Wang, Wei Cheng, Hengfei Li, Xiufang Wang, Hongfeng Zhang, Jifa Hu, Aiping Deng, Wei Cai, Wei Cai   +13 more
doaj   +1 more source

Periodontitis and metabolic dysfunction‐associated steatotic liver disease

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon, Erica Dorigatti de Avila, Davi da Silva Barbirato, Mariana Fampa Fogacci, Jamil Awad Shibli, Anton Sculean, Alpdogan Kantarci   +6 more
wiley   +1 more source

Immunohistochemical Characterisation of Mismatch Repair Proteins in Feline Cancers: A Pilot Study Using Validated Cross‐Reactive Antibodies

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT DNA mismatch repair (MMR) deficiency is a clinically important biomarker in human oncology, yet its relevance in feline neoplasia remains poorly understood due to limited characterisation and the absence of validated reagents. In this study, we established a practical immunohistochemistry (IHC) approach for evaluating feline MMR proteins by ...
Shoma Nishibori, Masashi Sakurai, Yumiko Kagawa, Kazuo Nishigaki, Takayuki Nakagawa, Sakuya Inanaga, Masaya Igase, Takuya Mizuno   +7 more
wiley   +1 more source

Frequency of rearrangements in lynch syndrome cases associated with MSH2: Characterization of a new deletion involving both EPCAM and the 5′ part of MSH2 [PDF]

, 2011
7 páginas, 3 figuras, 2 tablas.-- El pdf del artículo es la versión pre-print.-- et al.Lynch syndrome is caused by germline mutations in MSH2, MLH1, MSH6, and PMS2 mismatch repair genes and leads to a high risk of colorectal and endometrial cancer.
Acedo, Alberto, Mar Infante Sanz, Enrique Lastra Aras, Pérez-Cabornero, Lucía, Velasco, Eladio, Alberto Acedo Becares, Infante, Mar, Cristina Miner Pino, Durán, Mercedes, Lucia Pérez-Cabornero, Mercedes Durán Domínguez, Eladio Velasco Sampedro, Lastra, Enrique, Miner, Cristina   +13 more
core   +1 more source

Acetaldehyde and defective mismatch repair increase colonic tumours in a Lynch syndrome model with Aldh1b1 inactivation

Disease Models & Mechanisms, 2023
Guia Cerretelli, Ying Zhou, Mike F. Müller, David J. Adams, Mark J. Arends   +4 more
doaj   +1 more source