Results 61 to 70 of about 2,782,626 (284)

Melanotan-II reverses autistic features in a maternal immune activation mouse model of autism [PDF]

, 2019
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by impaired social interactions, difficulty with communication, and repetitive behavior patterns. In humans affected by ASD, there is a male pre-disposition towards the
Gould, Georgianna G, Lang, Jordan, Mazarati, Andrey, Medel-Matus, Jesus-Servando, Minakova, Elena, Reynolds, Ashley, Sankar, Raman, Shin, Don   +7 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Numerical investigation of mixed convection and viscous dissipation in couple stress nanofluid flow: A merged Adomian decomposition method and Mohand transform

Open Physics
This work focuses on the impact of a magnetic field and viscous dissipation on the mixed convective flow of a couple stress nanofluid over a sheet that is stretching linearly.
Khader Mohamed M., Adel Mohamed, Messaoudi Mohamed   +2 more
doaj   +1 more source

ANÁLISE DA SATISFAÇÃO DOS COLABORADORES EM RELAÇÃO A POLÍTICA DE TREINAMENTO E DESENVOLVIMENTO EM UMA ORGANIZAÇÃO MULTINACIONAL DE CUIABÁ – MT

Revista Estudos e Pesquisas em Administração, 2019
The main purposes of training and development in an organization correspond to the suitability of people to their culture, changing non-value-added attitudes, developing skills and adaptability to cope with the evolution and modernization of ...
Rosicley Nicolao de Siqueira, Fabricio Cesar de Moraes, Andrey Sartory, Ledian Cheila de Godoy, Moises Phillip Botelho   +4 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Composition, Order, and Motivation in Ezekiel’s Two Editions

Perichoresis: The Theological Journal of Emanuel University
The different textual shapes of the book of Ezekiel allow readers to understand the book’s growth, revealing both compositional technique and theological motivation for the new shape of scripture.
Mckenzie Tracy J.
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Three-dimensional finite-memory quasi-Newton inversion of the magnetotelluric based on unstructured grids

Open Geosciences
Simulation optimization of complex geological bodies is a necessary means to improve inversion accuracy and computational efficiency; thus, inversion of magnetotelluric (MT) based on unstructured grids has become a research hotspot in recent years.
Song Huadong, Xue Yunfeng, Yan Chaoxu
doaj   +1 more source

QSYP Peptide Sequence Is Selected from Phage Display Libraries by Bovine IgG Contaminants in Monoclonal Antibody Preparations

BioTechniques, 2003
A consensus peptide sequence, QSYP, appears as an artifact during the mapping of monoclonal antibodies (MAbs) using a random peptide phage display library.
J.M. Jacobs, B.W. Bailey, J.B. Burritt, S.G. Morrison, R.P. Morrison, E.A. Dratz, A.J. Jesaitis, M. Teintze   +7 more
doaj   +1 more source

On Drinfeld modular forms of higher rank II [PDF]

, 2017
We show that the absolute value $|f|$ of an invertible holomorphic function $f$ on the Drinfeld symmetric space $\OM^r$ $(r \geq 2)$ is constant on fibers of the building map to the Bruhat-Tits building $\MB\MT$.
Gekeler, Ernst-Ulrich
core   +4 more sources