Results 71 to 80 of about 2,782,626 (284)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Pattern and process of vegetation change (succession) in recent volcanic landscapes of New Zealand and Hawaii [PDF]

, 2010
Volcanic activity (including lava flows, debris flows and tephra eruptions) is a regular feature of many landscapes of the North Island of New Zealand and the Hawaiian archipelago.
Clarkson, Beverley R., Clarkson, Bruce D.   +1 more
core   +1 more source

Modified extended tanh-function method and nonlinear dynamics of microtubules

, 2012
We here present a model of nonlinear dynamics of microtubules (MT) in the context of modified extended tanh-function (METHF) method. We rely on the ferroelectric model of MTs published earlier by Satari\'c et al [1] where the motion of MT subunits is ...
Ali, Dustin, El-Wakil, Gross, Jovana Petrović, Kavitha, Kavitha, Kavitha, Louis Kavitha, Miljko V. Satarić, Satarić, Satarić, Satarić, Satarić, Schoutens, Slobodan Zdravković, Slobodan Zeković, Smirnov, Tuszyńsky, Zdravković   +19 more
core   +1 more source

Identification of poor households for premium exemptions in Ghana’s National Health Insurance Scheme: empirical analysis of three strategies [PDF]

, 2010
OBJECTIVES: To evaluate the effectiveness of three alternative strategies to identify poor households: means testing (MT), proxy means testing (PMT) and participatory wealth ranking (PWR) in urban, rural and semi-urban settings in Ghana.
Agyepong, Aikins, Arhin-Tenkorang, Asante, Baker, Bigman, Bitrán, Chambers, Coady, Coady, Collins, Coulombe, Deaton, Elbers, Filmer, Fofack, Garshong, Grosh, Hargreaves, Hentschel, Jaspars, Jehu-Appiah, Kraybill, Laderchi, McKenzie, Minot, MOH, MOH, MOH, Montgomery, Ridde, Rio Group, Ruggles, Sahn, Simanowitz, Tien, Van Campenhout, Vyas, Willis, Yates   +39 more
core   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

A ELASTICIDADE DE TRANSMISSÃO DE PREÇOS ENTRE OS ELOS DE MERCADO: Produtor, atacado e varejo na comercialização da carne bovina no período de 1997 a 2013

Revista Estudos e Pesquisas em Administração, 2020
O agronegócio brasileiro contribui essencialmente para o desenvolvimento econômico do país. Inserida nesse complexo está a cadeia de carne bovina com um percentual significativo para as exportações brasileiras impulsionando a economia através de sua ...
Anderson Nunes de Carvalho Vieira, Andrey Sartori, Fabrício César de Moraes, Rosicley Nicolao de Siqueira   +3 more
doaj   +1 more source

Dublin City University at CLEF 2004: experiments with the ImageCLEF St Andrew's collection [PDF]

, 2004
For the CLEF 2004 ImageCLEF St Andrew's Collection task the Dublin City University group carried out three sets of experiments: standard cross-language information retrieval (CLIR) runs using topic translation via machine translation (MT), combination ...
Groves, Declan, Jones, Gareth J.F., Khasin, Anna, Lam-Adesina, Adenike M., Mellebeek, Bart, Way, Andy   +5 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A Review of Metallothionein Isoforms and their Role in Pathophysiology

World Journal of Surgical Oncology, 2011
The Metallothionein (MT) is a protein which has several interesting biological effects and has been demonstrated increase focus on the role of MT in various biological systems in the past three decades. The studies on the role of MT were limited with few
Senthil kumar M, Manisenthil Kumar KT, Shyam Sunder A, Thirumoorthy N, Ganesh GNK, Chatterjee Malay   +5 more
doaj   +1 more source