Results 141 to 150 of about 11,769 (169)

Mutagenesis studies of the human MT2 melatonin receptor

Biochemical Pharmacology, 2003
Melatonin mediates its physiological effects through activation of high affinity G protein-coupled receptors. The vertebrate MT(1), MT(2) and Mel(1c) melatonin receptors are molecularly and pharmacologically distinct. Three molecular models of melatonin recognition for the MT(1) and/or Mel(1c) melatonin receptors have been proposed.
Matthew J, Gerdin, Faika, Mseeh, Margarita L, Dubocovich   +2 more
openaire   +2 more sources

The role of MT2-MMP in cancer progression

Biochemical and Biophysical Research Communications, 2010
The role of MT2-MMP in cancer progression remains to be elucidated in spite of many reports on MT1-MMP. Using a human fibrosarcoma cell, HT1080 and a human gastric cancer cell, TMK-1, endogenous expression of MT1-MMP or MT2-MMP was suppressed by siRNA induction to examine the influence of cancer progression in vitro and in vivo.
Emiko, Ito, Ikuo, Yana, Chisato, Fujita, Aiko, Irifune, Maki, Takeda, Ayako, Madachi, Seiji, Mori, Yoshinosuke, Hamada, Naomasa, Kawaguchi, Nariaki, Matsuura   +9 more
openaire   +2 more sources

Sleep–wake characterization of double MT1/MT2 receptor knockout mice and comparison with MT1 and MT2 receptor knockout mice

Behavioural Brain Research, 2013
The neurohormone melatonin activates two G-protein coupled receptors, MT1 and MT2. Melatonin is implicated in circadian rhythms and sleep regulation, but the role of its receptors remains to be defined. We have therefore characterized the spontaneous vigilance states in wild-type (WT) mice and in three different types of transgenic mice: mice with ...
Comai S., Ochoa-Sanchez R., Gobbi G.
openaire   +2 more sources

Strategies Leading To MT2 Selective Melatonin Receptor Antagonists

2003
Studies of the physiological actions of melatonin have been hindered by the lack of specific, potent and subtype selective agonists and antagonists. This paper reviews our progress in developing subtype selective melatonin antagonists. Evidence is presented suggesting the structural features conferring MT2 selective antagonism.
SPADONI, GILBERTO, BEDINI, ANNALIDA, PIERSANTI, GIOVANNI, MOR M., RIVARA S., TARZIA, GIORGIO   +5 more
openaire   +3 more sources

Impaired hippocampal long-term potentiation in melatonin MT2 receptor-deficient mice

Neuroscience Letters, 2006
The pineal product melatonin that acts on specific melatonin receptors has been implicated in pathobiological mechanisms of neuropsychiatric disorders including Alzheimer's disease. We used mice lacking melatonin MT(2) receptors (MT(2) knockouts) to investigate the role of these receptors in synaptic plasticity and learning-dependent behavior. In field
John, Larson, Ruth E, Jessen, Tolga, Uz, Ahmet D, Arslan, Murat, Kurtuncu, Marta, Imbesi, Hari, Manev   +6 more
openaire   +2 more sources

ZIP10 mediates renal MT2 production and attenuates oxidative stress

The FASEB Journal, 2017
We previously showed that metallothioneins (MTs) induced by zinc supplementation contribute to beneficial effects in the context of diabetic nephropathy (DN). The contribution of Zip10 to the regulation of MTs in the kidney was determined in this study.
Shoujin Hao, Gangqiang Ding, Hongbo Hao, Peiyao Tian, Shixue Li, Hong Zhao, Zbigniew Darzynkiewicz, Nicholas R. Ferreri   +7 more
openaire   +1 more source

Mammalian MT1 and MT2 metallothioneins differ in their metal binding abilities

Metallomics, 2013
Metallothioneins (MTs) constitute a universal family of polymorphic, ubiquitous small Cys-rich metal-binding polypeptides that in mammals are represented by four highly similar isoforms (MT1 to MT4). MT1 and MT2 have generally been considered as equivalent proteins, so that they are commonly referred to as MT1/MT2.
Ester, Artells, Òscar, Palacios, Mercè, Capdevila, Sílvia, Atrian   +3 more
openaire   +2 more sources

Avoiding anomalies in the mt2 algorithm by Martello and Toth

European Journal of Operational Research, 1995
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Melatonin, non-selective MT1/MT2 and selective MT2 receptor agonists: differential effects on the 24-hr vigilance states

2014
Melatonin (MLT) is a neurohormone implicated in several physiological processes such as sleep. Contrasting results have been produced on whether or not it may act as a hypnotic agent, and the neurobiological mechanism through which it controls the vigilance states has not yet been elucidated.
Ochoa Sanchez, R., Comai, S., SPADONI, GILBERTO, BEDINI, ANNALIDA, TARZIA, GIORGIO, Gobbi, G.   +5 more
openaire   +1 more source

Functional MT1 and MT2 melatonin receptors in mammals.

Endocrine, 2005
Melatonin, dubbed the hormone of darkness, is known to regulate a wide variety of physiological processes in mammals. This review describes well-defined functional responses mediated through activation of high-affinity MT1 and MT2 G protein-coupled receptors viewed as potential targets for drug discovery.
Margarita L, Dubocovich, Magdalena, Markowska   +1 more
openaire   +1 more source