Results 51 to 60 of about 13,446 (217)

Expression profiles of adult T-cell leukemia-lymphoma and associations with clinical responses to zidovudine and interferon alpha [PDF]

, 2010
Adult T-cell leukemia-lymphoma (ATLL) is an HTLV-1-associated lymphoproliferative malignancy that is frequently fatal. We compared gene expression profiles (GEPs) of leukemic specimens from nine patients with ATLL at the time of diagnosis and immediately
Alizadeh, A.A. (Ash A.), Bohen, S.P. (S.P.), Cubedo, E. (Elena), Harrington, W.J. (W. J.), Lossos, C. (Chen), Lossos, I.S. (Izidore S.), Martinez-Climent, J.A. (José Ángel), Ramos, J.C. (Juan Carlos)   +7 more
core   +1 more source

MT1 and MT2 melatonin receptors play opposite roles in brain cancer progression

Journal of Molecular Medicine, 2021
Primary brain tumors remain among the deadliest of all cancers. Glioma grade IV (glioblastoma), the most common and malignant type of brain cancer, is associated with a 5-year survival rate of
G. S. Kinker, L. H. Ostrowski, P. A. C. Ribeiro, R. Chanoch, S. M. Muxel, I. Tirosh, G. Spadoni, S. Rivara, V. R. Martins, T. G. Santos, R. P. Markus, P. A. C. M. Fernandes   +11 more
openaire   +3 more sources

Melatonin antagonizes lipopolysaccharide-induced pulpal fibroblast responses

BMC Oral Health, 2020
Background Pulpal inflammation is known to be mediated by multiple signaling pathways. However, whether melatonin plays regulatory roles in pulpal inflammation remains unclear.
Nutthapong Kantrong, Piyabhorn Jit-Armart, Uthaiwan Arayatrakoollikit   +2 more
doaj   +1 more source

Exogenous melatonin ameliorates steroid-induced osteonecrosis of the femoral head by modulating ferroptosis through GDF15-mediated signaling

Stem Cell Research & Therapy, 2023
Background Ferroptosis is an iron-related form of programmed cell death. Accumulating evidence has identified the pathogenic role of ferroptosis in multiple orthopedic disorders.
Wenming Li, Wenhao Li, Wei Zhang, Hongzhi Wang, Lei Yu, Peng Yang, Yi Qin, Minfeng Gan, Xing Yang, Lixin Huang, Yuefeng Hao, Dechun Geng   +11 more
doaj   +1 more source

Is there a role for melatonin in fibromyalgia? [PDF]

, 2019
Fibromyalgia, characterised by persistent pain, fatigue, sleep disturbance and cognitive dysfunction, is a central sensitivity syndrome that also involves abnormality in peripheral generators and in the hypothalamic pituitary adrenal axis.
Acuna-Castroviejo D, Escames G, Reiter RJ, Ambriz-Tututi M, Rocha-González HI, Cruz SL, et al., Bunney WE, Bunney BG, Castaño MY, Garrido M, Delgado-Adamez J, et al., Castaño MY, Garrido M, Rodríguez AB, et al., Caumo W, Hidalgo MP, Souza A, et al., Chen WW, Zhang X, Huang WJ., Citera G, Arias MA, Maldonado-Cocco JA, et al., Clauw DJ, Comai S, Gobbi G, de Zanette SA, Vercelino R, Laste G, et al., Fatima G, Das SK, Mahdi AA, Fayed N, Garcia-Campayo J, Magallón R, et al., Hardeland R, Cardinali DP, Srinivasan V, et al., Herrero JF, Laird JM, López-García JA, Hussain SA, Al-Khalifa II, Jasim NA, et al., Ismail SA, Mowafi HA, Laurido C, Pelissie T, Soto-Moyano R, et al., Lawson K, Macfarlane GJ, Kronisch C, Dean LE, et al., Masruha M, de Souza Vieira DS, Minett TS, et al., Masruha MR, Lin J, de Souza Vieira DS, et al., Musshoff U, Riewenherm D, Berger E, et al., Nava F, Carta G, Noseda R, Hernández A, Valladares L, et al., Pardini M, Cordano C, Benassi F, et al., Pyke TL, Osmotherly PG, Baines S, Queiroz LP, Quera Salva MA, Hartley S, Barbot F, et al., San L, Arranz B, Senel K, Baygutalp F, Baykal T, et al., Sluka KA, Clauw DJ, Srinivasan V, Brzezinski A, Pandi-Perumal SR, et al., Srinivasan V, Lauterbach EC, Ho KY, et al., Srinivasan V, Pandi-Perumal SR, Trahkt I, et al., Sánchez-Domínguez B, Bullón P, Román-Malo L, et al., Torres-Farfan C, Richter HG, Rojas-García P, et al., Vanecek J, Wan Q, Man HY, Liu F, et al., Webb SM, Wikner J, Hirsch U, Wetterberg L, et al., Wilhelmsen M, Amirian I, Reiter RJ, et al., Wolfe F, Clauw DJ, Fitzcharles MA, et al., Wood PB, Schweinhardt P, Jaeger E, et al., Üçeyler N, Zeller D, Kahn AK, et al.   +44 more
core   +1 more source

Melatonin Inhibits NF-κB/CREB/Runx2 Signaling and Alleviates Aortic Valve Calcification

Frontiers in Cardiovascular Medicine, 2022
Calcific aortic valve disease (CAVD) is linked to high mortality. Melatonin inhibits nuclear factor-kappa B (NF-κB)/cyclic AMP response element-binding protein (CREB), contributing to CAVD progression.
Shao-Jung Li, Shao-Jung Li, Shao-Jung Li, Shao-Jung Li, Wan-Li Cheng, Wan-Li Cheng, Wan-Li Cheng, Yu-Hsun Kao, Yu-Hsun Kao, Yu-Hsun Kao, Yu-Hsun Kao, Cheng-Chih Chung, Cheng-Chih Chung, Cheng-Chih Chung, Cheng-Chih Chung, Nguyen Ngoc Trang, Yi-Jen Chen, Yi-Jen Chen, Yi-Jen Chen, Yi-Jen Chen, Yi-Jen Chen   +20 more
doaj   +1 more source

Melatonin as a therapy in cardiac ischemia-reperfusion injury: Potential mechanisms by which MT2 activation mediates cardioprotection

Journal of Advanced Research, 2021
Introduction: Previous studies reported the beneficial effects of pretreatment with melatonin on the heart during cardiac ischemia/reperfusion (I/R) injury.
Kodchanan Singhanat, Nattayaporn Apaijai, Thidarat Jaiwongkam, Sasiwan Kerdphoo, Siriporn C. Chattipakorn, Nipon Chattipakorn   +5 more
doaj   +1 more source

Circadian rhythms and hormonal homeostasis: Pathophysiological implications [PDF]

, 2017
Over recent years, a deeper comprehension of the molecular mechanisms that control biological clocks and circadian rhythms has been achieved. In fact, many studies have contributed to unravelling the importance of the molecular clock for the regulation ...
Bruscalupi, Giovannella, Gnocchi, Davide
core   +2 more sources

Human Gastroenteropancreatic Expression of Melatonin and Its Receptors MT1 and MT2

PLOS ONE, 2015
The largest source of melatonin, according to animal studies, is the gastrointestinal (GI) tract but this is not yet thoroughly characterized in humans. This study aims to map the expression of melatonin and its two receptors in human GI tract and pancreas using microarray analysis and immunohistochemistry.Gene expression data from normal intestine and
Söderquist, Fanny, Hellström, Per M., Cunningham, Janet L.   +2 more
openaire   +5 more sources

Plant‐Derived Melatonin Inhibits Bacterial Virulence via CpxA/R Two‐Component System

Advanced Science, EarlyView.
Plant‐derived melatonin is sensed by CpxAE48/T51, which inhibits the phosphorylation cascade transmission from CpxAH240 to CpxRD52, resulting in the inhibition of DNA‐binding capacity of CpxR and subsequent T3SS genes expression in Pst DC3000. ABSTRACT In defending against pathogens, plants deploy diverse secondary metabolites and signaling molecules ...
Jin‐Wei Wei, Wei Liu, Bili Cao, Dan Zhao, Chengqiang Wang, Xin Hou, Tangyuan Ning, Biao Gong   +7 more
wiley   +1 more source