Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production [PDF]
, 2016 Self-tolerance and immunity are actively acquired in parallel through a poorly understood ability of antigen receptors to switch between signaling death or proliferation of antigenbinding lymphocytes in different contexts.
Domaschenz, Heather +8 more
core +1 more source
Mice lacking melatonin MT2 receptors exhibit attentional deficits, anxiety and enhanced social interaction [PDF]
Journal of Psychopharmacology, 2021 Background: Aside from regulating circadian rhythms, melatonin also affects cognitive processes, such as alertness, and modulates the brain circuitry underlying psychiatric diseases, such as depression, schizophrenia and bipolar disorder, via mechanisms that are not fully clear.
Thomson, David M. +4 more
openaire +5 more sources
Melatonin receptor expression in the zebra finch brain and peripheral tissues [PDF]
, 2012 The circadian endocrine hormone melatonin plays a significant role in many physiological processes such as modulating sleep/wake cycle and oxidative stress.
Brandstaetter, Roland +2 more
core +1 more source
Anti-Inflammatory Effects of Melatonin in Rats with Induced Type 2 Diabetes Mellitus
Life, 2022 Introduction: Insulin resistance is associated with a pro-inflammatory state increasing the risk for complications in patients with type 2 diabetes mellitus (T2DM).
Hande Yapislar +6 more
doaj +1 more source
Live Cell Imaging Unveils Multiple Domain Requirements for In Vivo Dimerization of the Glucocorticoid Receptor [PDF]
, 2014 Glucocorticoids are essential for life, but are also implicated in disease pathogenesis and may produce unwanted effects when given in high doses.
Alvarez, Lautaro Damian +14 more
core +3 more sources
Structure-based discovery of potent and selective melatonin receptor agonists
eLife, 2020 Melatonin receptors MT1 and MT2 are involved in synchronizing circadian rhythms and are important targets for treating sleep and mood disorders, type-2 diabetes and cancer.
Nilkanth Patel +8 more
doaj +1 more source
Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis. [PDF]
, 2016 The invasion-promoting MT1-MMP is a cell surface-associated collagenase with a plethora of critical cellular functions. There is a consensus that MT1-MMP is a key protease in aberrant pericellular proteolysis in migrating cancer cells and, accordingly, a
Cieplak, Piotr +5 more
core +1 more source
From implantation to birth: insight into molecular melatonin functions [PDF]
, 2018 Melatonin is a lipophilic hormone synthesized and secreted mainly in the pineal gland, acting as a neuroendocrine transducer of photoperiodic information during the night.
Carlomagno, Gianfranco +3 more
core +1 more source
Inactive matriptase-2 mutants found in IRIDA patients still repress hepcidin in a transfection assay despite having lost their serine protease activity. [PDF]
, 2012 L'article final de l'éditeur contient 9 pages. Le manuscrit accepté contient 32 pages.International audienceMutations of the TMPRSS6 gene, which encodes Matriptase-2, are responsible for iron-refractory iron-deficiency anemia.
Aguilar-Martinez, Patricia +12 more
core +3 more sources
Melatonin Receptors: A Key Mediator in Animal Reproduction
Veterinary Sciences, 2022 Melatonin, a hormone produced by the mammalian pineal gland, influences various physiological activities, many of which are related to animal reproduction, including neuroendocrine function, rhythm regulation, seasonal behavior, gonadogenesis, gamete ...
Yuan Gao +3 more
doaj +1 more source