Differential Function of Melatonin MT1 and MT2 Receptors in REM and NREM Sleep
Frontiers in Endocrinology, 2019 The pathophysiological function of the G-protein coupled melatonin MT1 and MT2 receptors has not yet been well-clarified. Recent advancements using selective MT1/ MT2 receptor ligands and MT1/MT2 receptor knockout mice have suggested that the activation ...
Gabriella Gobbi +2 more
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MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations [PDF]
Journal of Pineal Research, 2019 AbstractMelatonin (MLT) exerts its physiological effects principally through two high‐affinity membrane receptors MT1 and MT2. Understanding the exact mechanism of MLT action necessitates the use of highly selective agonists/antagonists to stimulate/inhibit a given MLT receptor. The respective distribution of MT1 and MT2 within the CNS and elsewhere is
Klosen, Paul +6 more
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Stimulatory Effects of Melatonin on Porcine In Vitro Maturation Are Mediated by MT2 Receptor. [PDF]
Int J Mol Sci, 2018 Lee S +4 more
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Activation of MT2 receptor ameliorates dendritic abnormalities in Alzheimer's disease via C/EBPα/miR-125b pathway. [PDF]
Aging Cell, 2019 Tang H +13 more
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Modeling the Heterodimer Interfaces of Melatonin Receptors
Frontiers in Cellular Neuroscience, 2021 Melatonin receptors are Class A G protein-coupled receptors (GPCRs) that regulate a plethora of physiological activities in response to the rhythmic secretion of melatonin from the pineal gland.
Lap Hang Tse +3 more
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Synthesis and functional characterization of substituted isoquinolinones as MT2-selective melatoninergic ligands. [PDF]
PLoS ONE, 2014 A series of substituted isoquinolinones were synthesized and their binding affinities and functional activities towards human melatonin MT1 and MT2 receptors were evaluated.
Yueqing Hu +4 more
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Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks. [PDF]
PLoS ONE, 2016 Melatonin is rhythmically secreted by both the pineal gland and retina in a circadian fashion, with its peak synthesis occurring during the night. Once synthesized, melatonin exerts its effects by binding to two specific G-protein coupled receptors ...
Sharon Owino +3 more
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Role of melatonin receptors in the effect of estrogen on brain edema, intracranial pressure and expression of aquaporin 4 after traumatic brain injury [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): Traumatic brain injury (TBI) is one of the most common causes of death and disability in modern societies. The role of steroids and melatonin is recognized as a neuroprotective factor in traumatic injuries.
Nader Shahrokhi +4 more
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Functional Expression of MT2 (Mel1b) Melatonin Receptors in Human PAZ6 Adipocytes [PDF]
Endocrinology, 2001 Several reports have demonstrated that the pineal hormone, melatonin, plays an important role in body mass regulation in mammals. To date, however, the target tissues and relevant biochemical mechanisms involved remain uncharacterized. As adipose tissue is the principal site of energy storage in the body, we investigated whether melatonin could also ...
L, Brydon +4 more
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Scientific Reports, 2022 Melatonin is a known modulator of follicle development; it acts through several molecular cascades via binding to its two specific receptors MT1 and MT2. Even though it is believed that melatonin can modulate granulosa cell (GC) functions, there is still
Asma Arjoune, Marc-André Sirard
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