Circadian Pattern of Melatonin MT1 and MT2 Receptor Localization in the Rat Suprachiasmatic Nucleus [PDF]
Journal of Circadian Rhythms, 2015 The suprachiasmatic nucleus (SCN) is the circadian pacemaker. The pineal hormone melatonin is involved in the regulation of circadian phase. As a part of the circadian system its synthesis and secretion is under SCN control.
Nermien Waly, Richard Hallworth
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Expression of melatonin receptors in trigeminal and sphenopalatine ganglia: potential targets for primary headache disorders [PDF]
The Journal of Headache and PainBackground Primary headache disorders such as migraine and cluster headache exhibit circadian and circannual variations in attack onset. Melatonin plays a central role in regulating biological rhythms and likely influences the timing of headache attacks.
Aida Maddahi +3 more
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Sperm freezability is associated with melatonin receptor expression in the sperm plasma membrane of Saanen goat bucks (Capra hircus) [PDF]
Veterinary WorldBackground and Aim: Cryopreservation is an essential assisted reproductive technology for preserving valuable animal genetics; however, it induces osmotic and oxidative stress that compromises sperm quality.
Alberto J. Cardenas-Padilla +1 more
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MT2 selective melatonin receptor antagonists: design and structure-activity relationships [PDF]
ARKIVOC, 2006 The neurohormone melatonin is involved in the regulation of many physiological functions, in particular those related to circadian and seasonal rhythms. In mammals, melatonin activates two GPCRs, named MT1 and MT2, and ligands of these receptors have been proposed for the treatment of different pathologies.
Silvia Rivara +6 more
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MT2 receptor mediates melatonin-induced thermogenic program in human myoblasts: insights for circadian syndrome and diabesity treatment [PDF]
Frontiers in PharmacologyBackgroundMelatonin is crucial for regulating circadian rhythms. Previous studies have demonstrated its ability to improve metabolic disorders, including obesity and associated diabetes (diabesity), in addition to its antioxidant, anti-inflammatory and ...
Diego Salagre +5 more
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Parental behavior, adult attachment, and DNA methylation of the MT2 oxytocin receptor gene region - The moderating role of neuroticism. [PDF]
PLoS ONEParental behavior, especially in childhood, affects the child's development in numerous ways. Over the last decade, the aim to get a deeper understanding of how early experiences influence behavior later in life has led to an increased popularity of ...
Laura Geißert, Juergen Hennig
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Melatonin inhibits muscular-mucosal stretch-sensitive bladder afferents via the MT2 receptors
Scientific Reports, 2022 Melatonin is a circadian rhythm regulator capable of controlling a variety of physiological processes in the body. It predominantly acts via the melatonin 1 (MT1) and MT2 receptors expressed in the CNS neurons and peripheral organs and tissues. Melatonin
Stewart Ramsay, Vladimir Zagorodnyuk
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Melatonin decreases excessive polyspermy for single oocyte in pigs through the MT2 receptor. [PDF]
Sci RepMelatonin supplementation during in vitro maturation (IVM) improves porcine oocyte maturation and embryonic development by exerting antioxidative effects. Nevertheless, the mechanism by which melatonin prevents polyspermy after in vitro fertilization (IVF) remains unclear.
Sun JT +10 more
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Different color lights on refractive status and secretion of neurotransmitters in the guinea pig model of myopia [PDF]
International Journal of OphthalmologyAIM: To evaluate the effect of different monochromatic lights on the refractive status and the secretion levels of neurotransmitters in the progressive myopic model of guinea pigs.
Xiao-Xia Li +4 more
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Loss of melatonin signaling increases the risk of T2DM caused by metabolic disorders [PDF]
Cell Communication and SignalingType 2 diabetes mellitus (T2DM) poses a significant global health challenge. Genome-wide Association Studies have linked T2DM to genetic variants in the melatonin receptor 1a (MTNR1A) and 1b (MTNR1B) genes, which encode the MT1 and MT2 receptors ...
Laiqing Yan +16 more
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