Results 81 to 90 of about 13,446 (217)

A Meta‐Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models

open access: yesJournal of Sleep Research, EarlyView.
How does sleep deprivation affect the brain? We performed a meta‐analysis of publicly available transcriptional profiling datasets characterising the effects of sleep deprivation on cortical gene expression (n = 293 mice, 16,290 genes) and validated our results in an independent sample (n = 222 mice).
Cosette A. Rhoads   +8 more
wiley   +1 more source

Sites of action of sleep and wake drugs: insights from model organisms [PDF]

open access: yes, 2013
Small molecules have been used since antiquity to regulate our sleep. Despite the explosion of diverse drugs to treat problems of too much or too little sleep, the detailed mechanisms of action and especially the neuronal targets by which these compounds
Rihel, J, Schier, AF
core   +1 more source

Effects of Agomelatine on Sleep Across Populations: A Systematic Review and Meta‐Analysis

open access: yesJournal of Sleep Research, EarlyView.
ABSTRACT Agomelatine, a melatoninergic antidepressant, is often prescribed to improve sleep disturbance, though meta‐analytic evidence is currently lacking. This systematic review and meta‐analysis assessed its efficacy and tolerability in sleep outcomes compared to placebo.
Anastasios Stefanou   +7 more
wiley   +1 more source

Melatonin Attenuates Anoxia/Reoxygenation Injury by Inhibiting Excessive Mitophagy Through the MT2/SIRT3/FoxO3a Signaling Pathway in H9c2 Cells

open access: yesDrug Design, Development and Therapy, 2020
Jinjing Wu,* Yanli Yang,* Yafen Gao, Zhaoqi Wang, Jun Ma Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University-Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, People’s Republic of China*These authors ...
Wu J, Yang Y, Gao Y, Wang Z, Ma J
doaj  

Pineal and cortical melatonin receptors MT1 and MT2 are decreased in Alzheimer’s disease

open access: yesEuropean Journal of Histochemistry, 2009
The pineal hormone melatonin is involved in physiological transduction of temporal information from the light dark cycle to circadian and seasonal behavioural rhythms, as well as possessing neuroprotective properties.
P Brunner   +5 more
doaj   +1 more source

Validierung von Genexpressionsanalysen in einem Mausmodell für Hirnschlag [PDF]

open access: yes, 2006
Zusammenfassung: Zur Identifizierung wichtiger Signalgene beim Schlaganfall im Mausmodell wurden Genexpressionsprofile mit Hilfe der Affymetrix-GeneChip-Technologie anfertigt und mir zu Beginn dieser Arbeit zur Verfügung gestellt.
Ziegler, G.
core  

Escape Body: A Gamified Problem‐Based Learning Project in Primary Education

open access: yesSchool Science and Mathematics, EarlyView.
ABSTRACT Young learners' lack of motivation to study scientific‐related subjects nowadays is a topic of concern in our society. This study followed a quasi‐experimental design with a predominantly quantitative methods approach, complemented by qualitative data, to investigate how the combination of gamified and problem‐based learning could influence ...
Sergio Tirado‐Olivares   +3 more
wiley   +1 more source

Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells. [PDF]

open access: yes, 2016
BackgroundOur previous studies showed that the non-psychoactive cannabinoid, cannabidiol (CBD), ameliorates the clinical symptoms in mouse myelin oligodendrocyte glycoprotein (MOG)35-55-induced experimental autoimmune encephalomyelitis model of multiple ...
Coppola, Giovanni   +5 more
core   +2 more sources

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes [PDF]

open access: yes, 2012
Human matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site where a Zn(2+) atom, coordinated by three histidines, plays the catalytic role ...
Adachi   +1200 more
core   +1 more source

Loss of Cx43 in Murine Sertoli Cells Leads to Altered Prepubertal Sertoli Cell Maturation and Impairment of the Mitosis-Meiosis Switch. [PDF]

open access: yes, 2020
Male factor infertility is a problem in today's society but many underlying causes are still unknown. The generation of a conditional Sertoli cell (SC)-specific connexin 43 (Cx43) knockout mouse line (SCCx43KO) has provided a translational model ...
Behr, Rüdiger   +10 more
core   +1 more source

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