Results 151 to 160 of about 166,442 (338)

mtDNA Heteroplasmy at the Core of Aging-Associated Heart Failure. An Integrative View of OXPHOS and Mitochondrial Life Cycle in Cardiac Mitochondrial Physiology [PDF]

, 2021
Álvaro A. Elorza, Juan Pablo Soffia
openalex   +1 more source

Geological processes shaping freshwater biodiversity: a synthesis of global evidence

Biological Reviews, EarlyView.
ABSTRACT Recent genomic data highlight the key roles of geological processes in shaping the diversification and biogeography of freshwater lineages. Specifically, physical processes such as tectonic uplift, erosion, glaciation, lake formation, and sea‐level fluctuation contribute extensively to the evolution of biotic diversity within and among ...
Jonathan M. Waters, Christopher P. Burridge, David Craw, James S. Albert   +3 more
wiley   +1 more source

Evolutionary associations between sand seatrout (Cynoscion arenarius) and silver seatrout (C. nothus) inferred from morphological characters, mitochondrial DNA, and microsatellite markers [PDF]

, 2009
The evolutionary associations between closely related fish species, both contemporary and historical, are frequently assessed by using molecular markers, such as microsatellites.
Anderson, Joel D., Karel, William J., McDonald, Dusty L., Sutton, Glen R.   +3 more
core  

mtDNA diversity in azara's owl monkeys (Aotus azarai azarai) of the Argentinean Chaco [PDF]

, 2011
Paul Babb, Eduardo Fernández‐Duque, Caitlin A. Baiduc, Pascal Gagneux, Siân Evans, Theodore G. Schurr   +5 more
openalex   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Generation of trans-mitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in a structural gene using ES cells [PDF]

, 2006
Atsuko Kasahara, Kaori Ishikawa, Makiko Yamaoka, Masahito Ito, Naoki Watanabe, Miho Akimoto, Akitsugu Sato, Kazuto Nakada, Hitoshi Endo, Yoko Suda, Shin-Ichi Aizawa, Jun‐Ichi Hayashi   +11 more
openalex   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Mitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo [PDF]

, 2021
Ugne Zekonyte, Sandra R. Bacman, Jeff Smith, Wendy Shoop, Cláudia V. Pereira, Ginger Tomberlin, James B. Stewart, Derek Jantz, Carlos T. Moraes   +8 more
openalex   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Phylogeographic analysis of mtDNA variation in four ethnic populations from Yunnan Province: new data and a reappraisal [PDF]

, 2002
Yong‐Gang Yao, Y.-P. Zhang
openalex   +1 more source