Results 161 to 170 of about 123,318 (262)

Is DNA metabarcoding an option for formaldehyde‐preserved zooplankton time series?

Limnology and Oceanography: Methods, EarlyView.
Abstract The recovery of amplifiable DNA from formaldehyde‐fixed (FF) zooplankton samples has long been considered problematic, but advances in degraded‐DNA retrieval have renewed interest in FF samples. To access the information stored in long‐term zooplankton time series, we evaluated methods for extracting amplifiable DNA from community samples ...
Aitor Albaina, Anders Lanzén, Irati Miguel, Fernando Rendo, María Santos   +4 more
wiley   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Long-read sequencing enables high-accuracy mitochondrial heteroplasmy detection in Parkinson's disease. [PDF]

BMC Genomics
Lüth T, Schaake S, Much C, Belyea MM, Seibler P, Grünewald A, May P, Klein C, Weissensteiner H, Trinh J.   +9 more
europepmc   +1 more source

Body Size, Dental Pathology, and Maternal Genetic Diversity of Ancient Horses in the Eastern Baltic Sea Region and Western Russia

International Journal of Osteoarchaeology, EarlyView.
ABSTRACT The early evolutionary history of modern domestic horses (Equus caballus/Equus ferus caballus), known as the DOM2 lineage, is well documented due to numerous archaeological and ancient DNA (aDNA) studies. Although many uncertainties remain in the domestication timeline, current evidence suggests that the domestication of modern horses began in
Johanna Honka, Daniela Salazar, Arthur O. Askeyev, Igor V. Askeyev, Oleg V. Askeyev, Jouni Aspi, Gulshat Sh. Asylgaraeva, Markku Niskanen, Kristiina Mannermaa, Suvi Olli, Noora Piipponen, Giedrė Piličiauskienė, Dilyara N. Shaymuratova, Renat R. Valiev, Laura Kvist   +14 more
wiley   +1 more source

Functional Characterization of CYP26B1 Short Isoform as a Novel Locus for Obesity in Indigenous Americans From Arizona

Obesity, EarlyView.
ABSTRACT Objective To identify heritable factors that affect BMI among Indigenous Americans, we previously conducted a genome‐wide association study using 7.9 million imputed genetic variants from 6789 participants. This study sought to identify a mechanistic link between variants with the strongest association with BMI and adipocyte metabolism ...
Fehmida Farid Khan, Michael Traurig, Kendrick Freeland, Robert L. Hanson, Paolo Piaggi, Leslie J. Baier   +5 more
wiley   +1 more source

Free Mitochondrial DNA and Mitophagy Dysfunction in Diabetic Kidney Disease: A Central Mitochondrial-Inflammatory Axis Driving Progressive Renal Injury. [PDF]

Cells
Das A, Lalu E, Awasthi V, Ben Dhaou C, Hussein H, Gerhard G, Bahmed K, Lee I, Puri V, Bouchareb R.   +9 more
europepmc   +1 more source

Elimination of mitochondrial DNA using meganucleases

openLe malattie mitocondriali sono malattie genetiche che colpiscono la catena respiratoria mitocondriale e di conseguenza la produzione di ATP. Possono essere dovute a mutazioni sia del DNA mitocondriale (mtDNA) sia del genoma nucleare: il mtDNA e ...
BRUSCAGNIN, ELENA
core  

The role of tryptophan hydroxylase‐1 in metabolic dysfunction‐associated steatotic liver disease

Pediatric Investigation, EarlyView.
Silencing hepatic tryptophan hydroxylase 1 (TPH1) alleviated diet‐induced steatotic liver disease by reducing lipid accumulation, oxidative stress, inflammation, fibrosis, and hepatocyte apoptosis. These protective effects were mediated, at least in part, through restoration of Parkin‐dependent mitochondrial autophagy, identifying hepatic TPH1 as a ...
Shuangzhen Jia, Xiaolin Ye, Zhaoxia Wang, Jie Wu   +3 more
wiley   +1 more source

Needle in a haystack: Holocene history of European larch in Central Europe revisited

PLANTS, PEOPLE, PLANET, EarlyView.
Defining nativity of species is crucial for their management. However, this is a complex task, especially for species that have been used and spread by humans for a long time. We combined paleoecological records with extensive genetic data to investigate the Holocene history of European larch—a common and economically important tree species in Central ...
Martin Prach, Petr Pokorný, Kristýna Hošková, Daniel Vondrák, Pavel Bednář, Jindřich Prach, Jana Hanzal Šedivá, Hana Drahošová, Kateřina Podrábská, Přemysl Bobek, Jan Smyčka, Tomáš Fér   +11 more
wiley   +1 more source

Cardiopulmonary Exercise Testing (CPET) Guided Sub‐Anaerobic Threshold Rehabilitation in MELAS Syndrome: A Case Report

The Kaohsiung Journal of Medical Sciences, EarlyView.
Yu‐Lien Tsai, Kun‐Yuan Cheng, Yen‐Sen Lu, Ko‐Long Lin   +3 more
wiley   +1 more source