Results 181 to 190 of about 123,318 (262)

Photoactivated iridium(III) complexes drive pyroptosis–necroptosis synergy for multi‐network photoimmunotherapy of renal cell carcinoma

Smart Molecules, EarlyView.
Photoactivated iridium(III) complexes trigger mitochondrial DNA leakage and Ca²⁺ efflux, simultaneously driving pyroptosis and necroptosis to synergistically enhance immunogenic cell death. This multi‐network cascade promotes dendritic cell maturation and CD8⁺ T cell activation, achieving potent photoimmunotherapy of renal cell carcinoma.
Xin Qin, Meng‐Di Chen, Wenqi Gao, Yiping Wang, Lin‐Qing Liu, Zhen Teng, Tienan Qi, Qiyuan Wang, Yuxuan Wang, Daoxiang Li, Keqiang Yan, Ling Pan, Zhongwei Zhao, Shuo Zhao, Kang‐Nan Wang, Shuai Fu, Nengwang Yu   +16 more
wiley   +1 more source

Assessing genetic diversity in a reintroduced Mediterranean griffon vulture Gyps fulvus population to inform long‐term conservation management

Wildlife Biology, EarlyView.
Reintroductions play a key role in conservation biology. Their long‐term success strongly depends on maximizing the genetic diversity of founders, as well as on ensuring ecological connectivity with adjacent populations. Accordingly, evaluating the conservation status of reintroduced populations to limit the loss of their genetic diversity requires ...
Nicolò Borgianni, Mario Posillico, Lorenzo Attili, Paolo Ciucci, Rita Lorenzini, Luisa Garofalo   +5 more
wiley   +1 more source

The mitochondrial DNA-cGAS-STING axis in colorectal cancer: a focused review of context-dependent roles and therapeutic opportunities. [PDF]

Front Mol Biosci
Gui H, Zhang Y, Yuan X.
europepmc   +1 more source

Biology, ecology, and conservation of the Italian hare Lepus corsicanus: a review

Wildlife Biology, EarlyView.
The Italian hare Lepus corsicanus, an endemic lagomorph of Italy, serves as a critical case study in evolutionary biology and conservation. Once taxonomically debated, modern genetic and morphological analyses confirm its status as a distinct Pleistocene lineage restricted to the central‐southern Italian Peninsula and Sicily.
Pierangelo Freschi, Valter Trocchi
wiley   +1 more source

Encapsulated mitochondrial transplantation: Advancing organelle therapeutics. [PDF]

Signal Transduct Target Ther
Yang HJ, Jeong PS, Kim SU.
europepmc   +1 more source

Recent progress in studies of the last million years of human physical and behavioural evolution Avancées récentes dans l’étude du dernier million d'années d’évolution physique et éthologique de l'espèce humaine

Journal of the Royal Anthropological Institute, EarlyView.
This article presents a synthesis of recent developments in the study of human evolution over the past five years. It begins with an overview of hominin species nomenclature and diversity, followed by an examination of the proposed population bottleneck ∼900,000 years ago.
James Cole, Eleanor M.L. Scerri, Mateja Hajdinjak, Chris Stringer   +3 more
wiley   +1 more source

Mitochondrial Metabolic Reprogramming in Macrophages: A Key Driver of Rheumatoid Arthritis. [PDF]

J Inflamm Res
Zhao J, Pan F, Nie G, Zheng F, Wang L, Han C.   +5 more
europepmc   +1 more source

Gough's Cave and biomolecular archaeology: a story of evolving interpretation Archéologie biomoléculaire à la grotte de Gough's Cave : une interprétation en constante évolution

Journal of the Royal Anthropological Institute, EarlyView.
Gough's Cave is a key archaeological site that has been at heart of British archaeology for the past century. Professor Chris Stringer, whom this special issue honours, has been a key figure in excavations and research projects at the site for many decades.
William A. Marsh
wiley   +1 more source

Hominin dispersals: causes, conditions, and outcomes Dispersions des hominines : causes, conditions et issues

Journal of the Royal Anthropological Institute, EarlyView.
The ‘Out of Africa’ model that has dominated palaeoanthropology for nearly three decades was originally based on five elements: a recent ancestry to human populations; an African origin for the ancestral population; limited or no gene flow among archaic hominins and no admixture between modern humans and Neanderthals; a marked difference between the ...
Robert A. Foley, Marta Mirazón Lahr
wiley   +1 more source

Brazilian spotlight on INTERPOL's I‐Familia: Policy, practice, and international missing persons identification

Journal of Forensic Sciences, EarlyView.
Abstract The disappearance of individuals is a global humanitarian and public security issue that requires coordinated national and international responses. INTERPOL's I‐Familia database is a global DNA database that uses kinship matching to support identification of missing persons (MP) and unidentified human remains (UHR) when a direct DNA profile ...
Aline Minervino, Bruno Samezima, Roberto Monteiro Neto, Apoena Lopes, Simone de Jesus, Laryssa Bezerra, Samuel Ferreira, Christiane Cutrim, Liliane Pires, Ronaldo Silva Júnior, António Amorim, Laura Cainé   +11 more
wiley   +1 more source