International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 112-120, April 2025.Abstract Objective In the present study, a bidirectional two‐sample Mendelian randomization approach was utilized to explore potential causal relationships between mitochondrial DNA copy number (mtDNA‐CN) and ovary‐related reproductive disorders (ORRDs), including ovarian dysfunction, ovarian cyst, polycystic ovary syndrome (PCOS), premature ovarian ...
Ke Peng +4 more
wiley +1 more source
BAX, VDAC, Gasdermin, and Permeability Transition Pores in Inflammatory Mitochondrial DNA Release: Is This the "Hole" Story? [PDF]
CellsZhang N, Freeman DD, Polster BM.
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The womb as the cradle of longevity: Perinatal origins of biological aging
International Journal of Gynecology &Obstetrics, EarlyView.Abstract The perinatal period is increasingly recognized as an important determinant of biological aging trajectories and disease susceptibility across the lifespan. This narrative review synthesizes current evidence linking intrauterine exposures to adult health outcomes across three biological dimensions: fetal programming, maternal influences, and ...
Sevim Ozge Ozdemir, Ebru Davutoglu
wiley +1 more source
Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review
Journal of Applied Toxicology, EarlyView.ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli +5 more
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Mitochondria provide multiple functions for cellular physiology. Transplantation of mitochondria isolated from gastric epithelial cells GES‐1 reducing the malignancy of gastric cancer cells AGS was previously reported. To elucidate the underlying mechanisms, TMT‐based proteomic analysis coupling ingenuity pathway software prediction revealed ...
Ping‐Chen Chen +9 more
wiley +1 more source
The Regulatory Role and Mechanism of Myoferlin in Mitophagy During Papillary Thyroid Carcinogenesis
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Papillary thyroid carcinoma (PTC) is the most prevalent subtype of thyroid cancer; however, the regulatory mechanisms by which mitophagy influences its progression remain inadequately elucidated. This study sought to examine the role of myoferlin (MYOF) in mitophagy and its molecular basis during PTC development. Utilizing three paired PTC and
Wen‐Chao Lyu +6 more
wiley +1 more source
Why diabetes matters in dementia studies: Failure to account for diabetes status masks regional mitochondrial DNA copy number changes in human hippocampus, amygdala, and cerebellum in Alzheimer's disease. [PDF]
Alzheimers DementKaikini A +7 more
europepmc +1 more source
Analysis of genetic diversity and phylogenetic evolution of cattle population in the Ili River Valley region, Xinjiang, based on mtDNA D-loop sequence. [PDF]
PLoS OneAmat G +10 more
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The role of cytosolic mitochondrial DNA as a mitochondrial danger signal for stromal fibroblasts in forming the tumor-promoting microenvironment following radiation exposure. [PDF]
J Radiat ResShimura T.
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