Results 191 to 200 of about 156,870 (288)

Transcriptomic analysis of cells following decreased mitochondrial DNA-copy number reveals compensatory mechanisms in mitochondrial DNA replication and cellular energetics. [PDF]

Exp Cell Res
Xie J, Win PW, Newcomb C, Zeng S, Castellani CA, Arking DE.   +5 more
europepmc   +1 more source

Reassessing the mitochondrial DNA evidence for migration at the Mesolithic–Neolithic transition [PDF]

, 2008
Bonsall, Clive, Pickard, Benjamin, Pickard, Catriona   +2 more
core  

Out in the cold? A review of Early Middle Palaeolithic settlements in northern Central Europe, age data and geological preconditions for site formation and preservation

Boreas, EarlyView.
The characteristics of settlement of Neanderthals in northern Central Europe during the earlier phases of the Middle Palaeolithic (Marine Isotope Stage 8–6) have been a matter of debate for decades, specifically regarding the population dynamics at such latitudes during the coldest phases. In this paper, we review the known archaeological record of the
Gianpiero Di Maida, Jutta Winsemann, Malte Hoffmann, Tobias Lauer, Utz Böhner, Thomas Terberger   +5 more
wiley   +1 more source

Mitochondrial DNA drives NLRP3-IL-1β axis activation in microglia by binding to NLRP3, leading to neurodegeneration in Parkinson's disease models. [PDF]

Cell Death Dis
Gan Q, Fu X, Zhou T, Fan N, Nan N, Wang Y, Yang Y, Gou S, Hu L, Zhou S.   +9 more
europepmc   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Mammalian mitochondrial DNA accumulates insertions and deletions with age in energetically demanding tissues. [PDF]

Mol Biol Evol
Torres-Gonzalez E, Arbeithuber B, Stoler N, Cremona MA, Shebl O, Ebner T, Tiemann-Boege I, Diaz FJ, Chiaromonte F, Makova KD.   +9 more
europepmc   +1 more source

Mitochondrial Transfer in the Tumor Microenvironment

Cancer Science, EarlyView.
Mitochondria are actively exchanged among tumor, immune, stromal, and neuronal cells within the tumor microenvironment. Such transfer rewires tumor metabolism, promotes immune evasion, and drives therapy resistance. Targeting mitochondrial transfer or harnessing mitochondrial transplantation represents a promising strategy to restore antitumor immunity
Ryo Omae, Takamasa Ishino, Yosuke Togashi   +2 more
wiley   +1 more source

Whole Exome Sequencing for Romanian Patients With Neurodevelopmental Disorders Through an International Collaboration

Clinical Genetics, EarlyView.
Whole exome sequencing for Romanian patients with neurodevelopmental disorders through an international collaboration—this study has provided a 50% diagnostic yield for patients with NDDs (27 positive results from 54 patients), supporting the implementation of a WES analysis that can identify SNVs, small INDELs, CNVs, and mitochondrial variants ...
Alexandru Caramizaru, Cristina Durac, Andreea Dumitrescu, Alexandru Calota‐Dobrescu, Alix de Becdelièvre, Marina Konyukh, Denise Cassandrini, Hane Lee, Go Hun Seo, Seung Woo Ryu, Mihai Cucu, Iuliana Manuela Dragomir, Andreea Catana, Homa Tajsharghi, Edoardo Malfatti, Florin Burada, Amelia Dobrescu   +16 more
wiley   +1 more source

Busulfan resistance in AML is associated with changes in mitochondrial copy number and lipid metabolism. [PDF]

Sci Rep
Mlakar V, Jurković Mlakar S, Gloor Y, Dupanloup I, Sarmiento Y, Boudal-Khosbheen M, Marino D, Uppugunduri CRS, Ansari M.   +8 more
europepmc   +1 more source

Cellular Signalling Networks in High Altitude Pulmonary Hypertension: From Canonical Pathways to Emerging Targets

Cell Proliferation, EarlyView.
This review elucidates the intricate cellular signalling networks involved in high‐altitude pulmonary hypertension (HAPH), integrating canonical pathways like HIF, MAPK and BMP with emerging targets such as Wnt/β‐catenin, Notch, Hippo‐YAP and IL‐6. It highlights potential therapeutic strategies targeting these pathways to mitigate vascular remodelling ...
Sheng Ding, Ju Chen, Zhaoyang Li, Yang Yu, Weijie Wang, Yan Liao, Jin Yang, Dianxiang Lu, Yujiang Fan   +8 more
wiley   +1 more source