Results 231 to 240 of about 166,442 (338)

A model for de novo pigmentation of amelanotic retinal pigment epithelial cells

Acta Ophthalmologica, EarlyView.
Abstract Purpose Retinal Pigment Epithelial (RPE) cells perform critical functions in the visual cycle. Their melanin pigmentation, which is organized into specialized compartments – melanosomes, is highly critical for proper vision. A chemical method to induce pigmentation in a non‐pigmented model of ARPE‐19 cells was applied using L‐DOPA as a ...
Santosh Gupta, Lyubomyr Lytvynchuk, Taras Ardan, Hana Studenovska, Georgina Faura, Lars Eide, Ljubo Znaor, Slaven Erceg, Knut Stieger, Jan Motlik, Goran Petrovski   +10 more
wiley   +1 more source

Age at type 2 diabetes onset and risk of dementia: The modifying role of genetic susceptibility and mitochondrial function. [PDF]

J Nutr Health Aging
Dong W, Yuan Q, Wu B, Gao S, Zhang Y, Pan Y, Zhou K, Jiang H.   +7 more
europepmc   +1 more source

Morphological and Morphometric Analysis of Animal Hair From 18th Century Burial Sites in Mazamet (Southwest France)

Archaeometry, EarlyView.
ABSTRACT Morphological and morphometric analysis of archaeological animal hairs offers a nondestructive method to explore past clothing. We examined hair from two 18th‐century burial areas (SP03 and SP04) in Mazamet, France. SP03 specimens exhibited a continuous medulla, a low medullary index (0.2 ± 0.03) and cuticular features suggesting goat or ...
C. Michel, S. Duchesne, F. Bourgailh, F. Callede, C. H. Le Noheh, M.‐L. Merleau, D. Paya, I. Baker, F. Savall, C. Guilbeau‐Frugier   +9 more
wiley   +1 more source

The nuclear and mitochondrial genomes need to tango. How is their dance synchronized during development? [PDF]

NAR Mol Med
St John JC.
europepmc   +1 more source

Excess Weight Impairs Oocyte Quality, as Reflected by mtDNA and BMP-15 [PDF]

Emiliya Sigal, Maya Shavit, Yuval Atzmon, Nardin Aslih, Asaf Bilgory, Daniela Estrada, Mediea Michaeli, N. Rotfarb, Yasmin Shibli Abu‐Raya, Shilhav Meisel-Sharon, Einat Shalom‐Paz   +10 more
openalex   +1 more source

Kinetic properties of mutant deoxyguanosine kinase in a case of reversible hepatic mtDNA depletion [PDF]

, 2007
Bénédicte Mousson de Camaret, Jan‐Willem Taanman, Sylvie Padet, Maïté Chassagne, Martine Mayençon, P. Clerc-Renaud, G. Mandon, M. T. Zabot, Alain Lachaux, Dominique Bozon   +9 more
openalex   +1 more source

Out in the cold? A review of Early Middle Palaeolithic settlements in northern Central Europe, age data and geological preconditions for site formation and preservation

Boreas, EarlyView.
The characteristics of settlement of Neanderthals in northern Central Europe during the earlier phases of the Middle Palaeolithic (Marine Isotope Stage 8–6) have been a matter of debate for decades, specifically regarding the population dynamics at such latitudes during the coldest phases. In this paper, we review the known archaeological record of the
Gianpiero Di Maida, Jutta Winsemann, Malte Hoffmann, Tobias Lauer, Utz Böhner, Thomas Terberger   +5 more
wiley   +1 more source

Functional Impact Score of Mitochondrial Variants and Its Relationship With Functional Connectivity of the Brain: Potential Origins of Premature Aging in Young Adulthood. [PDF]

Hum Brain Mapp
Mareckova K, Mendes-Silva AP, Mareček R, Jordánek T, Pačínková A, Klánová J, Gonçalves VF, Nikolova YS.   +7 more
europepmc   +1 more source

Targeting Genome Maintenance Defects of Cancers Using Chain‐Terminating Nucleoside Analogs

Cancer Science, EarlyView.
Nucleoside analogs interfere with DNA replication either by their chain‐terminating properties or by serving as DNA damage on the template. The genome maintenance pathways required to maintain cellular tolerance to each nucleoside analog vary depending on the drug.
Ryotaro Kawasumi, Rubaiat E. Tabassum, Kouji Hirota   +2 more
wiley   +1 more source

Advances in gene therapy for mitochondrial genetic disorders: current status and clinical implementation challenges. [PDF]

J Transl Med
Lyu L, Qie B, He Y, Chen F, Liu B.
europepmc   +1 more source