Results 151 to 160 of about 400,251 (340)
Advanced Functional Materials, EarlyView.Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu +7 more
wiley +1 more source
Renal Failure, 2019 Objective: To compare the anti-peritoneal fibrotic effects between a mammalian target of rapamycin complex 1-specific blocker and a phosphatidyl-inositol 3-kinase/mammalian target of rapamycin dual-blocker. Methods: A total of 40 male Sprague-Dawley rats
Tian Xu +5 more
doaj +1 more source
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Advanced Functional Materials, EarlyView.Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR [PDF]
, 2001 Mehran S. Neshat +9 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto +2 more
wiley +1 more source
Drug Design, Development and Therapy, 2021 Ai-Yuan Xiu,1 Qian Ding,2 Zhen Li,2 Chun-Qing Zhang1,2 1Department of Gastroenterology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China; 2Department of Gastroenterology, Shandong ...
Xiu AY, Ding Q, Li Z, Zhang CQ
doaj
FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse [PDF]
, 2001 Kathryn E. Hentges +6 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.This study develops a 3D vascular injury model using a microphysiological system that mimics key features of intimal hyperplasia. Antiproliferative drugs reduced VSMC proliferation but worsened endothelialdenudation. A combination of diphenyleneiodonium and quercetin effectively reduced proliferation and migration of VSMC and inflammation while ...
Ungsig Nam +7 more
wiley +1 more source
A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt
, 2000 Masahiro Aoki +2 more
openalex +2 more sources
Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR [PDF]
, 2003 Hongbing Zhang +8 more
openalex +2 more sources