Results 151 to 160 of about 424,341 (313)

Liver transplantation [PDF]

open access: yes, 2014
Purpose of review: Long-term survival of liver transplant recipients is threatened by increased rates of de-novo malignancy and recurrence of hepatocellular carcinoma (HCC), both events tightly related to immunosuppression.
Burroughs, AK   +2 more
core  

Spi1 regulates the microglial/macrophage inflammatory response via the PI3K/AKT/mTOR signaling pathway after intracerebral hemorrhage

open access: gold, 2023
Guoqiang Zhang   +9 more
openalex   +1 more source

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

open access: yesAdvanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu   +9 more
wiley   +1 more source

Supplementary Figure 3 from The mTOR Kinase Inhibitors, CC214-1 and CC214-2, Preferentially Block the Growth of EGFRvIII-Activated Glioblastomas [PDF]

open access: gold, 2023
Beatrice Gini   +29 more
openalex   +1 more source

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

open access: yesAdvanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao   +5 more
wiley   +1 more source

Effect of 8 weeks of resistance training and concurrent resistance-aerobic training on phospho-mTOR and phospho-p70S6K responses in skeletal muscle of rat

open access: yesمجله دانشگاه علوم پزشکی گرگان, 2020
Background and Objective: Exercise-induced muscle hypertrophy occurs through increased rate of muscle protein synthesis that is regulated via molecular signaling pathways. The mammalian target of rapamycin (mTOR) pathway is believed to play a major role,
Morteza Sangdevini   +2 more
doaj  

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

open access: yesAdvanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong   +5 more
wiley   +1 more source

Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells [PDF]

open access: bronze, 2015
Sarah A. Head   +14 more
openalex   +1 more source

Inactivation of AXL in Cardiac Fibroblasts Alleviates Right Ventricular Remodeling in Pulmonary Hypertension

open access: yesAdvanced Science, EarlyView.
Pulmonary hypertension (PH) is a progressive condition with high morbidity and mortality, largely owing to right ventricular (RV) failure resulting from maladaptive remodeling. Our study provides strong evidence in support of a critical, detrimental role for AXL as a previously unrecognized determinant driving RV fibrotic pathology in PH.
Li‐Wei Wu   +17 more
wiley   +1 more source

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