Results 151 to 160 of about 427,120 (360)

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

Advanced Healthcare Materials, EarlyView.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu, Yiben Ouyang, Bo Wang, Xiaochun Zhang, Yanjun Guan, Ruichao He, Yuhui Cui, Junli Wang, Qianru Yao, Yixiao Tan, Xiwei Peng, Xing Xiong, Sice Wang, Dongdong Li, Haofeng Cheng, Tianqi Su, Xiaoyang Fu, Jinjuan Zhao, Mingqian Yu, Yi Wang, Jiang Peng, Yu Wang   +21 more
wiley   +1 more source

Supplementary Figure S2 from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP

, 2023
Taru Muranen, Laura M. Selfors, Julie Chernov Hwang, Lisa L. Gallegos, Jonathan L. Coloff, Carson C. Thoreen, Seong A. Kang, David M. Sabatini, Gordon B. Mills, Joan S. Brugge   +9 more
openalex   +1 more source

Nano‐Engineered Titanium Implants Loaded With Gingival Fibroblasts‐Derived Microvesicles Enhance Early Osseointegration And Soft Tissue Attachment In Vivo

Advanced Healthcare Materials, EarlyView.
Our study showed that human primary gingival fibroblast–derived microvesicles on nano‐engineered titanium implants promote early osseointegration and soft‐tissue attachment in vivo. ABSTRACT Titanium dental implants require both reliable osseointegration and peri‐implant soft tissue seal formation to ensure long‐term success. While osseointegration has
Pingping Han, Chun Liu, Anjana Jayasree, Kamil Sokolowski, Andrew Liaw, Dingbin Liu, Carlos Salomon, Karan Gulati, Ryan SB Lee, Baoxin Huang, Sašo Ivanovski   +10 more
wiley   +1 more source

TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis [PDF]

, 2023
Huadie Liu, Yujing Liu, Seung‐Gi Jin, Jennifer Johnson, Hongwen Xuan, Di Lu, Jianshuang Li, Lukai Zhai, Xianfeng Li, Yaguang Zhao, Minmin Liu, Sonya Craig, Joseph S. Floramo, Vladimir Molchanov, Jie Li, Jia‐Da Li, Connie M. Krawczyk, Xiaobing Shi, Gerd P. Pfeifer, Tao Yang   +19 more
openalex   +1 more source

Bone Healing Around Implants in Normal and Medically Compromised Conditions: Osteoporosis and Diabetes

Advanced Healthcare Materials, EarlyView.
xx xx. ABSTRACT Osseointegration of orthopedic and dental implants is influenced by local and systemic factors, including their physicochemical surface properties and the patient's overall health status. Titanium and its alloys have been a longstanding standard for bone implants due to their innate biocompatibility and mechanical properties.
Dainelys Guadarrama Bello, Fabio Variola, Antonio Nanci   +2 more
wiley   +1 more source

Erratum: Differentiation of human neuroblastoma cells toward the osteogenic lineage by mTOR inhibitor [PDF]

, 2016
A Carpentieri, E Cozzoli, M Scimeca, Elena Bonanno, Anna Maria Sardanelli, Alessandra Gambacurta   +5 more
openalex   +1 more source

Related Article from Serum Cholesterol and mTOR Inhibitors: Surrogate Biomarker or Epiphenomenon?

, 2023
Daniel C. Cho, Michael B. Atkins
openalex   +1 more source

Low‐Temperature Fabrication of Thymosin β4‐Loaded Soluble Microneedles to Promote Wound Healing by Specific Binding to Downregulated Immune Regulators Vsig4 and IL22rɑ2

Advanced Healthcare Materials, EarlyView.
Schematic diagram depicting the fabrication and application of thymosin β4 (Tβ4)‐loaded microneedle patches for wound treatment. The Tβ4 was loaded into chitosan (CS) and sucrose MNs under mild conditions (4°C, 65% relative humidity). The Tβ4 MN patch specifically binds to the downregulated immune regulators Vsig4 and IL22rα2, thereby accelerating ...
Shilong He, Mei Yuan, Changkang Feng, Yixuan Zhang, Jinjing Che   +4 more
wiley   +1 more source

Neuroprotective Role of Orientin on β-amyloidinduced Cell Death in SH-SY5Y Neuronal Cells via mTOR Signaling Pathway

, 2023
Ying Pei Wong, Rhun Yian Koh, Kenny Leong Voon, Anna Pick, K.B. Ling, Z Zhu, C Yang, A Iyaswamy, S Krishnamoorthi, S Sreenivasmurthy, J Liu, Z Wang, B Tong, J Song, J Lu, K Cheung, M Li, S Oddo, Y Kim, K Guan, B Law, A Ling, R Koh, S Chye, Y Wong, R Subramaniam, F Roediger, B Jordan, M Mattson, J Keller, G Waeg, D Butterfield, C Pocernich, A Cardin, C Racine, C Lauderback, D Butterfield, J Tanaka, Y Yuda, T Miura, S Muraoka, Y Fujimoto, T Collins, M Berridge, P Lipp, M Bootman, S Hauptmann, I Scherping, S Drse, U Brandt, K Schulz, M Jendrach, K Leuner, A Eckert, W Mller, K Lim, A Sasmita, A Ling, R Koh, K Voon, Y Say, Y Wong, L Yu, S Wang, X Chen, H Yang, X Li, Y Xu, X Zhu, A Dinkova-Kostova, A Abramov, A Gureev, V Popov, A Starkov, C Goodman, D Mayhew, T Hornberger, A Tramutola, J Triplett, F Di Domenico, D Niedowicz, M Murphy, R Coccia, M Perluigi, D Butterfield, J Frey, B Jacobs, C Goodman, T Hornberger, H Lee, B Kwon, C Lemere, S De La Monte, K Itamura, A Ha, H Querfurth, R Hresko, M Mueckler   +97 more
openalex   +1 more source