Results 151 to 160 of about 266,976 (313)

Decision letter for "Growth inhibition and suppression of the mTOR and Wnt/beta-catenin pathways in T-acute lymphoblastic leukemia by rapamycin and MYCN depletion"

, 2020

openalex   +1 more source

Developmentally Inspired, Mechanical–Metabolic Dual Gradient Osteochondral Constructs Bridging Regeneration and Therapeutic Screening

Advanced Science, EarlyView.
A developmentally inspired osteochondral construct integrates mechanical and metabolic dual gradients within a 3D‐printed platform. Human MSC spheroids are spatially directed to form cartilage–bone interfaces, enabling evaluation of regeneration without biochemical reagents and assessment of drug responses. This physiologically relevant, phase‐specific
Yurim Choi, Wonjun Jang, Raehui Kang, Ulziituya Batjargal, Jihyeon Song, Soojin Park, MinSeok Kim, Hyobum Cho, Junhyung Kim, Yu Shrike Zhang, Han‐Jun Kim, Junmin Lee   +11 more
wiley   +1 more source

Mechanistic Target of Rapamycin and Megalencephaly: Novel Research Strategies for Therapeutic Discovery. [PDF]

Epilepsy Curr
Pan T, Parker W, Iffland PH, Dang L, Crino PB.   +4 more
europepmc   +1 more source

Supplementary Figure 1 from Hierarchical phosphorylation of HOXB13 by mTOR dictates its activity and oncogenic function in prostate cancer

Yonghong Chen, Catherine R. Dufour, Lingwei Han, Ting Li, Hui Xia, Vincent Giguère   +5 more
openalex   +1 more source

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

Spatial dynamics of mTOR pathway activity during bovine embryo development. [PDF]

Front Cell Dev Biol
Berling FP, Bacaro VBG, de Paschoal RI, Milazzotto MP, Goissis MD.   +4 more
europepmc   +1 more source

Dual inhibition of mTOR and calcineurin pathways mitigates missing self-induced NK cells-mediated microvascsular inflammation : Supplemental Data

Sarah Hamada, Jack Beadle, Alice Koenig, Basile Sugranes, John R. Ferdinand, Chien‐Chia Chen, Virginie Mathias, Maëva Eloudzeri, Thomas Barba, Helena Paidassi, Carole Saison, Valérie Dubois, Emmanuel Morelon, Walzer Thierry, Antoine Marçais, Maud Rabeyrin, Marion Rabant, Patrick Bruneval, Maud Racapé, Jean Paul Duong Van Huyen, Menna R Clatworthy, Candice Roufosse, O. Thaunat   +22 more
openalex   +1 more source

Calcium Channel Blockers Inhibit Pancreatic Neuroendocrine Neoplasms Progression via Cav1.2‐Epigenetic Circuit

Advanced Science, EarlyView.
Our study reveals a novel mechanism of a positive regulatory circuit between Cav1.2 and H3K27ac for pancreatic neuroendocrine neoplasms (pNENs) progression. Cav1.2 is identified as a crucial target for promoting disease progression and correlates with malignant behaviors, which are remarkably inhibited by the administration of calcium channel blockers (
Yangyinhui Yu, Qiongcong Xu, Jinzhao Xie, Mingjian Ma, Xitai Huang, Yinhao Shi, Jiawei Zhou, Enliang Zhu, Ziyi Zhao, Ning Zhang, Zhide Liu, Jingyuan Ye, Xiaoyu Yin   +12 more
wiley   +1 more source

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source

GLUT5-Driven Gut-Liver Axis Injury Mediating Olanzapine-Induced NAFLD and Dapagliflozin Intervention. [PDF]

Drug Des Devel Ther
Chen X, Zhang Y, Wang J, Chen L, He SM, Wang DD.   +5 more
europepmc   +1 more source