Results 311 to 320 of about 75,068 (344)

Weight Loss‐Associated Remodeling of Adipose Tissue Immunometabolism

Obesity Reviews, EarlyView.
ABSTRACT Obesity is a multifactorial condition characterized by excessive adiposity and systemic chronic low‐grade inflammation. Recent literature reflects a growing appreciation for the complex interplay between metabolism and the immune system in the pathogenesis of obesity‐related health conditions.
Paulo José Basso, Alejandro Schcolnik‐Cabrera, Mengyi Zhu, Erin Strachan, Xavier Clemente‐Casares, Sue Tsai   +5 more
wiley   +1 more source

Orthoflavivirus infection and the mTOR signaling pathway. [PDF]

Front Microbiol
Zhang Y, Ba J, Luan J, Qi Z, Liu B.
europepmc   +1 more source

The Landscape of Cancer Metabolism as a Therapeutic Target

Pathology International, EarlyView.
ABSTRACT Cancer cells reprogram their metabolism during progression to adapt to the tumor microenvironment, which is characterized by distinct differences in nutrient availability, oxygen concentrations, and acidity. This metabolic reprogramming can simultaneously create metabolic vulnerabilities unique to cancer cells, making cancer metabolism a ...
Kenji Ohshima
wiley   +1 more source

Integrated transcriptomic and functional modeling reveals AKT and mTOR synergy in colorectal cancer. [PDF]

Sci Rep
Duleba M, Zimoląg E, Szuszkiewicz J, Serocki M, Szklarczyk J, Dracz O, Kurzejamski A, Więckowska I, Chmiel M, Lipert B, Sarad K, Krawczyk J, Bryzghalov O, Stachowicz-Wałaszek A, Pyziak K, Drozdowska J, Baczyński K, Wojtowicz K, Chronowski M, Rataj K, Otrocka M, Mikula M, Feliksiak P, Dziadziuszko R, Rzymski T, Thomason A, Brzózka K, Mazan A.   +27 more
europepmc   +1 more source

Effects of resistance exercise, collagen ingestion and circulating oestrogen concentration on collagen synthesis in a female athlete: A case report

Experimental Physiology, EarlyView.
Abstract We investigated the effects of resistance exercise (RE), hydrolysed collagen (HC) ingestion and circulating oestrogen concentration on collagen synthesis in a naturally menstruating female CrossFit athlete. In a double‐blind, randomised cross‐over design, the participant (36 years; height 1.61 m; mass 82.6 kg) consumed 0 or 30 g HC prior to ...
Joonsung Lee, Jonathan C. Y. Tang, John Dutton, Rachel Dunn, William D. Fraser, Kevin Enright, David R. Clark, Claire E. Stewart, Robert M. Erskine   +8 more
wiley   +1 more source

Saturated phosphatidic acids induce mTORC1-driven integrated stress response contributing to glucolipotoxicity in hepatocytes. [PDF]

Am J Physiol Gastrointest Liver Physiol
Guo R, Li Y, Jiang Y, Khan MW, Layden BT, Song Z.   +5 more
europepmc   +1 more source

Muscle wasting in cancer cachexia: Mechanisms and the role of exercise

Experimental Physiology, EarlyView.
Abstract Cancer cachexia (CC) is a multifactorial disease marked by a severe and progressive loss of lean muscle mass and characterized further by inflammation and a negative energy/protein balance, ultimately leading to muscle atrophy and loss of muscle tissue.
Zoe P. Libramento, Louisa Tichy, Traci L. Parry   +2 more
wiley   +1 more source

Loss of genome maintenance is linked to mTOR complex 1 signaling and accelerates podocyte damage. [PDF]

JCI Insight
Braun F, Mandel AM, Blomberg L, Wong MN, Chatzinikolaou G, Meyer DH, Reinelt A, Nair V, Akbar-Haase R, McCown PJ, Haas F, Chen H, Rahmatollahi M, Fermin D, Ebbestad R, Slaats GG, Bork T, Schell C, Koehler S, Brinkkoetter PT, Lindenmeyer MT, Cohen CD, Kann M, Unnersjö-Jess D, Bloch W, Sampson MG, Dollé ME, Puelles VG, Kretzler M, Garinis GA, Huber TB, Schermer B, Benzing T, Schumacher B, Kurschat CE.   +34 more
europepmc   +1 more source

Single-Cell Profiling and Proteomics-Based Insights Into mTORC1-Mediated Angio+TAMs Polarization in Recurrent IDH-Mutant Gliomas. [PDF]

CNS Neurosci Ther
Wang X, Gu J, Tang H, Gu L, Bi Y, Kong Y, Shan Q, Yin J, Lou M, Li S, Liu Y.   +10 more
europepmc   +1 more source