Results 311 to 320 of about 108,192 (330)

mTORC1 inhibition by sirolimus as adjunctive treatment in experimental pneumococcal meningitis. [PDF]

Brain Commun
Koning R, Bakker D, van Roon MA, Jaspers V, Brouwer MC, van de Beek D.   +5 more
europepmc   +1 more source

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Limiting mTORC1

Science Signaling, 2013
A protein complex identified as a negative regulator of the mTORC1 protein kinase complex has tumor suppressor functions.
openaire   +2 more sources

Seeing mTORC1 specificity

Science, 2016
Structural information reveals how a multiprotein complex responds to amino acid abundance [Also see Research Articles by Wolfson et al. and Aylett et al. and
Gwen R. Buel, John Blenis
openaire   +1 more source

MTORC1-dependent reprogramming

Science Signaling, 2020
DDIT4 and IFRD1 trigger the inhibition and reactivation of MTORC1 during regenerative repair.
openaire   +1 more source

Lysosomal cholesterol activates mTORC1

Science, 2017
Cholesterol Sensing The mTORC1 kinase is a master nutrient sensor that governs cellular metabolism. When dysregulated, this kinase drives several human diseases, including cancer and diabetes. Recent work has delineated a pathway through which amino acids regulate mTORC1.
openaire   +2 more sources

mTORC1 goes sensorless

Science Signaling, 2019
A metabolite of leucine regulates mTORC1 through acetylation of Raptor in certain cell types and tissues.
openaire   +1 more source

mTORC1 signalling and mRNA translation

Biochemical Society Transactions, 2009
Signalling through mTORC1 (mammalian target of rapamycin complex 1) is important in controlling many cell functions, including protein synthesis, which it activates. mTORC1 signalling is activated by stimuli which promote protein accumulation such as anabolic hormones, growth factors and hypertrophic stimuli.
openaire   +3 more sources

Chaperoning mTORC1 Activity

Science Signaling, 2010
Chaperone availability regulates mTORC1 signaling, providing a link between protein quality control and translation.
openaire   +1 more source