Results 321 to 330 of about 75,068 (344)

The Role of Protein Kinases in the Suppressive Phenotype of Myeloid-Derived Suppressor Cells. [PDF]

Int J Mol Sci
Kali A, Abdolla N, Perfilyeva YV, Ostapchuk YO, Tleulieva R.   +4 more
europepmc   +1 more source

mTORC1 cooperates with tRNA wobble modification to sustain the protein synthesis machinery. [PDF]

Nat Commun
Hermann J, Borteçen T, Kalis R, Kowar A, Pechincha C, Vogt V, Schneider M, Helm D, Krijgsveld J, Loayza-Puch F, Zuber J, Palm W.   +11 more
europepmc   +1 more source

Ablation of LAT2 Transporter Causes Intramuscular Glutamine Accumulation and Inhibition of Fasting-Induced Proteolysis. [PDF]

J Cachexia Sarcopenia Muscle
Espino-Guarch M, Huang SSY, Vilches C, Prat E, El Nahas R, Missous G, Bodoy S, Sathappan A, Al-Aghbar MA, Mayayo C, Olivé M, Busquets-Rius S, Sebastián D, Zorzano A, Palacin M, van Panhuys N, Nunes V.   +16 more
europepmc   +1 more source

Leucine and mTORC1: a complex relationship [PDF]

American Journal of Physiology-Endocrinology and Metabolism, 2012
Amino acid availability is a rate-limiting factor in the regulation of protein synthesis. When amino acid supplies become restricted, mammalian cells employ homeostatic mechanisms to rapidly inhibit processes such as protein synthesis, which demands high levels of amino acids.
Andrew R. Tee, Kayleigh M. Dodd
openaire   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

mTORC1 and ferroptosis: Regulatory mechanisms and therapeutic potential

Bioessays, 2021
Ferroptosis, a form of regulated cell death triggered by lipid hydroperoxide accumulation, has an important role in a variety of diseases and pathological conditions, such as cancer.
Guang Lei, L. Zhuang, B. Gan
semanticscholar   +1 more source

mTORC1 drives granulomas

Nature Reviews Immunology, 2017
MTORC1-dependent macrophage proliferation and glycolysis drive granuloma formation in sarcoidosis.
openaire   +3 more sources

mTORC1 signalling and mRNA translation

Biochemical Society Transactions, 2009
Signalling through mTORC1 (mammalian target of rapamycin complex 1) is important in controlling many cell functions, including protein synthesis, which it activates. mTORC1 signalling is activated by stimuli which promote protein accumulation such as anabolic hormones, growth factors and hypertrophic stimuli.
openaire   +4 more sources

MAF1: a new target of mTORC1

Biochemical Society Transactions, 2011
Yeast and mammalian MAF1 are both regulated by the TOR (target of rapamycin) pathway. However, the exact mechanisms of regulation diverge at TOR, with yeast Maf1 phosphorylated mainly by the TORC1 (TOR complex 1) substrate Sch9 kinase and mammalian MAF1 by mTORC1 (mammalian target of rapamycin complex 1) itself.
openaire   +2 more sources

An arginine sensor for mTORC1

Science Signaling, 2016
Binding of arginine to CASTOR1 disrupts its binding to a complex that promotes mTORC1 activity.
openaire   +2 more sources