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Thwarting Dyskinesia by Targeting mTORC1
Science Signaling, 2009Blocking mTORC1 activity may decrease the unwanted involuntary movements associated with l -DOPA treatment.
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Lysosomal catch-and-release controls mTORC1
Nature Cell Biology, 2018Rag GTPases facilitate mTORC1 activation by recruiting it to Rheb at the lysosome when amino acids are abundant. A study now shows that the amino acid-induced change in the GTP/GDP-binding state of the Rag heterodimer paradoxically increases its dynamic release from the Ragulator at the lysosome and may limit mTORC1 activation.
Aaron M, Hosios, Brendan D, Manning
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mTORC1 Stimulates Glutamine Metabolism
Science Signaling, 2013The mammalian target of rapamycin complex 1 promotes glutamine metabolism by repressing expression of the gene encoding the sirtuin SIRT4.
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2009
mTORC1 is an important regulator of cell growth and cell proliferation and its activity is adjusted in response to multiple cues including oxygen levels. Under conditions of hypoxia, mTORC1 is inhibited. Hypoxia-induced mTORC1 inhibition typically involves the REDD1 protein.
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mTORC1 is an important regulator of cell growth and cell proliferation and its activity is adjusted in response to multiple cues including oxygen levels. Under conditions of hypoxia, mTORC1 is inhibited. Hypoxia-induced mTORC1 inhibition typically involves the REDD1 protein.
openaire +1 more source