Results 331 to 340 of about 75,068 (344)

MTORC1-dependent reprogramming

Science Signaling, 2020
DDIT4 and IFRD1 trigger the inhibition and reactivation of MTORC1 during regenerative repair.
openaire   +2 more sources

The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease

Nature reviews. Molecular cell biology, 2023
Claire Goul, R. Peruzzo, R. Zoncu
semanticscholar   +1 more source

Seeing mTORC1 specificity

Science, 2016
Structural information reveals how a multiprotein complex responds to amino acid abundance [Also see Research Articles by Wolfson et al. and Aylett et al. and
Gwen R. Buel, John Blenis
openaire   +2 more sources

Lysosomal cholesterol activates mTORC1

Science, 2017
Cholesterol Sensing The mTORC1 kinase is a master nutrient sensor that governs cellular metabolism. When dysregulated, this kinase drives several human diseases, including cancer and diabetes. Recent work has delineated a pathway through which amino acids regulate mTORC1.
openaire   +3 more sources

TSC on the peroxisome controls mTORC1

Nature Cell Biology, 2013
mTOR is a central controller that integrates many inputs to regulate cell growth and ensure cellular homeostasis. The mTORC1 inhibitor TSC (tuberous sclerosis complex) on the peroxisome is found to inhibit mTORC1 in response to endogenous reactive oxygen species.
Benjamin, D., Hall, M. N.
openaire   +3 more sources

mTORC1 goes sensorless

Science Signaling, 2019
A metabolite of leucine regulates mTORC1 through acetylation of Raptor in certain cell types and tissues.
openaire   +2 more sources

Nutrient-sensing mTORC1 and AMPK pathways in chronic kidney diseases

Nature Reviews Nephrology, 2022
Christopher Q. Huynh, J. Ryu, Jooho Lee, Ayaka Inoki, K. Inoki   +4 more
semanticscholar   +1 more source

Inhibiting mTORC1 at the Peroxisome

Science Signaling, 2013
Reactive oxygen species produced by the peroxisome inhibit mTORC1 localized at these catabolic organelles.
openaire   +2 more sources

Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma

Nature Metabolism, 2022
Fangzhou Liu, Tian Tian, Zhen Zhang, Shanshan Xie, Jiecheng Yang, Linyu Zhu, Wen Wang, Cheng Shi, L. Sang, Kaiqiang Guo, Zuo-zhen Yang, Lei Qu, Xiangrui Liu, Jian Liu, Qingfeng Yan, Huai-qiang Ju, Wenqi Wang, Hai-long Piao, Jianzhong Shao, Tianhua Zhou, Aifu Lin   +20 more
semanticscholar   +1 more source

SAR1B senses leucine levels to regulate mTORC1 signalling

Nature, 2021
Jie Chen, Yuhui Ou, Rong Luo, Jie Wang, Dong Wang, Jialiang Guan, Yi Li, P. Xia, Peng R. Chen, Ying Liu   +9 more
semanticscholar   +1 more source