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mTORC1 Signaling and Hypoxia [PDF]
, 2009 mTORC1 is an important regulator of cell growth and cell proliferation and its activity is adjusted in response to multiple cues including oxygen levels. Under conditions of hypoxia, mTORC1 is inhibited. Hypoxia-induced mTORC1 inhibition typically involves the REDD1 protein.
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Feeding induces cholesterol biosynthesis via the mTORC1–USP20–HMGCR axis
Nature, 2020Xiao-Yi Lu +10 more
semanticscholar +1 more source
2009
The best-understood targets for mTOR complex 1 (mTORC1) are proteins that are involved in mRNA translation or in its control. They include the ribosomal protein S6 kinases and the eukaryotic initiation factor (eIF) 4E-binding proteins (4E-BPs). The latter regulate the availability of the cap-binding protein eIF4E and the formation of eIF4F complexes ...
Bruno D. Fonseca +3 more
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The best-understood targets for mTOR complex 1 (mTORC1) are proteins that are involved in mRNA translation or in its control. They include the ribosomal protein S6 kinases and the eukaryotic initiation factor (eIF) 4E-binding proteins (4E-BPs). The latter regulate the availability of the cap-binding protein eIF4E and the formation of eIF4F complexes ...
Bruno D. Fonseca +3 more
openaire +2 more sources
Science Signaling, 2010
Chaperone availability regulates mTORC1 signaling, providing a link between protein quality control and translation.
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Chaperone availability regulates mTORC1 signaling, providing a link between protein quality control and translation.
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