Results 51 to 60 of about 227,429 (291)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Triagem in vitro de compostos isolados de plantas com potencial atividade imunomodulatória sobre linfócitos B [PDF]
, 2012 TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.A etiologia de diversos distúrbios clínicos associados ao sistema imune é conferida a desordens autorreativas ou deficiências na resposta humoral dos ...
Uggioni, Kamille Duarte Uggioni
core
MTT Assay validation of EGFR and c-MET combination. [PDF]
, 2019 (A). MTT assay experimental schema. (B) MTT assay of HCC78 cell line shows synergistic effects of Crizotinib and Erlotinib treatment. (C) shows short-term effects of EGFR and c-MET inhibitors’ combination index in 11 cell lines include 2 control cell ...
Mukesh Bansal (494487) +8 more
core +1 more source
The Iraqi Journal of Agricultural science, 2023 In this study, four types of basil seed extracts were used, being cold aqueous extract, hot aqueous extract, petroleum ether extract, and methanolic extract.Nine concentrations (10000, 5000, 2500, 1250, 625, 312.56, 156.25, 78.125, 39.0, 0.0) µg/ml were
Ayeda M.M, J. M. Awda
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
MTT assay of artonin E on various cell lines. [PDF]
, 2016 MTT assay of artonin E on various cell lines.
Faiqah Ramli (747582) +7 more
core +1 more source
Biobacta Journal of Biochemistry and Molecular BiologyBerberine, an isoquinoline derivative alkaloid, has recently been shown to have cytotoxicity and antitumor activity. The present study aimed to investigate the effect of Berberine at different concentrations (400, 200, 100, 50, 25µg/ml) on cell culture ...
Ahmed Alshanon
doaj +1 more source
Research in Pharmaceutical Sciences, 2019 Quinazolinone and benzimidazole are both fused heterocyclic compounds which have shown valuable biological properties including cytotoxic, antibacterial, and antifungal activities.
Elham Taherian +4 more
doaj +1 more source
Critical Appraisal of the MTT Assay in the Presence of Rottlerin and Uncouplers [PDF]
Biological Procedures Online, 2009 Rottlerin is a natural product isolated from Mallotus philippinensis. This polyphenolic compound, originally described as a selective inhibitor of PKCδ, can inhibit many other PKC-unrelated kinases and has a number of biological actions, including mitochondrial uncoupling effects.
Maioli E. +5 more
openaire +6 more sources