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Nowe oblicze mucyny MUC1 w progresji nowotworowej - rola podjednostki MUC1-C
Postępy Higieny i Medycyny Doświadczalnej, 2019 openaire +1 more source
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Immunotherapy, 2010
The overexpression and aberrant glycosylation of MUC1 is associated with a wide variety of cancers, making it an ideal target for immunotherapeutic strategies. This review highlights the main avenues of research in this field, focusing on adenocarcinomas, from the preclinical to clinical; the problems and possible solutions associated with each ...
Beatson, Richard +2 more
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The overexpression and aberrant glycosylation of MUC1 is associated with a wide variety of cancers, making it an ideal target for immunotherapeutic strategies. This review highlights the main avenues of research in this field, focusing on adenocarcinomas, from the preclinical to clinical; the problems and possible solutions associated with each ...
Beatson, Richard +2 more
openaire +3 more sources
Non-cysteine linked MUC1 cytoplasmic dimers are required for Src recruitment and ICAM-1 binding induced cell invasion [PDF]
Molecular Cancer, 2011 Background The mucin MUC1, a type I transmembrane glycoprotein, is overexpressed in breast cancer and has been correlated with increased metastasis.
Erik Lillehoj, Judith Hugh
exaly +2 more sources
MUC1 Aptamer Targeted SERS Nanoprobes [PDF]
Advanced Functional Materials, 2017 Recently, surface‐enhanced Raman scattering (SERS) nanoprobes (NPs) have shown promise in the field of cancer imaging due to their unparalleled signal specificity and high sensitivity. This study reports the development of a DNA aptamer targeted SERS NP.
Suchetan Pal +2 more
exaly +3 more sources
Cancer Immunology, Immunotherapy, 2000
Analyses of MUC1-specific cytotoxic T cell precursor (CTLp) frequencies were performed in mice immunized with three different MUC1 vaccine immunotherapeutic agents. Mice were immunized with either a fusion protein comprising MUC1 and glutathione S-transferase (MUC1-GST), MUC1-GST fusion protein coupled to mannan (MFP) or with a recombinant vaccinia ...
B, Acres +8 more
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Analyses of MUC1-specific cytotoxic T cell precursor (CTLp) frequencies were performed in mice immunized with three different MUC1 vaccine immunotherapeutic agents. Mice were immunized with either a fusion protein comprising MUC1 and glutathione S-transferase (MUC1-GST), MUC1-GST fusion protein coupled to mannan (MFP) or with a recombinant vaccinia ...
B, Acres +8 more
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MUC1 expression in plasmacytoma
Leukemia Research, 2001Plasmacytoma (Pm) is a plasma cell (PC) neoplasia consisting of PCs and some of them show progression to multiple myeloma. But there is no clear indicators predicting this progression. In this study, MUC1 expression was evaluated in Pm cases to determine the predictive value and was compared with histopathologic grade which is known to be a prognostic ...
Paydaş S. +4 more
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BJU International, 2003
OBJECTIVE To detect the expression and transcription pattern of MUC1 in benign and malignant disease, and in two widely studied cell lines, and to investigate the glycosylation of MUC‐1 in bone metastasis of prostate cancer, as mucins have been implicated in the progression and behaviour of several cancers.
I C, Schut +6 more
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OBJECTIVE To detect the expression and transcription pattern of MUC1 in benign and malignant disease, and in two widely studied cell lines, and to investigate the glycosylation of MUC‐1 in bone metastasis of prostate cancer, as mucins have been implicated in the progression and behaviour of several cancers.
I C, Schut +6 more
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MUC1 Expression in Hemopoietic Tissues
Journal of Hematotherapy & Stem Cell Research, 2000409 To the editor: The specificity of detection of disseminated cancer by reverse transcriptase polymerase chain reaction (RT-PCR) amplification of so-called tissue-specific genes has been discussed controversially. Dent et al. described in a recent paper the expression of MUC1 by hemopoietic cells of different origin.
W, Krüger, N, Kröger, A R, Zander
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MUC1 in carcinoma-host interactions
Glycoconjugate Journal, 2000Many carcinoma-associated markers are glycoconjugates whose expression undergoes temporal or spatial regulation. Mucin-1 (MUC1), discovered through monoclonal antibody technology, is a well-documented example of such a molecule and influences numerous pathophysiological behaviors, such as the invasion and metastasis of carcinoma cells.
K, Denda-Nagai, T, Irimura
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MUC1, The Renaissance Molecule
Journal of Mammary Gland Biology and Neoplasia, 2001MUC1 is a large, heavily glycosylated mucin expressed on the apical surfaces of most simple, secretory epithelia including the mammary gland, gastrointestinal, respiratory, urinary and reproductive tracts. Although MUC1 was thought to be an epithelial-specific protein, it is now known to be expressed on a variety of hematopoietic cells as well.
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