Results 211 to 220 of about 39,306 (244)

Running a MUC1

Nature Reviews Cancer, 2012
The UK press got carried away with a cancer story this week. It seems that a universal cancer vaccine is on its way, despite the fact that it has only been trialled in ten patients (with five more still to be recruited).
openaire   +1 more source

Synthesis of MUC1–lipopeptide chimeras

Chemical Communications, 2010
An efficient method for the convergent assembly of MUC1-lipopeptide vaccine candidates is described. Chimeras consisting of MUC1 glycopeptides (bearing multiple copies of the T(N) and T tumour-associated carbohydrate antigens) tethered to the lipopeptide immunoadjuvant Pam(3)CysSer were synthesised in high yields using a fragment-based condensation ...
Brendan L, Wilkinson, Lara R, Malins, Candy K Y, Chun, Richard J, Payne   +3 more
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Immunization with a Synthetic Human MUC1 Glycopeptide Vaccine against Tumor‐Associated MUC1 Breaks Tolerance in Human MUC1 Transgenic Mice

ChemMedChem, 2017
AbstractBreaking tolerance is crucial for effective tumor immunotherapy. We showed that vaccines containing tumor‐associated human MUC1 glycopeptides induce strong humoral antitumor responses in mice. The question remained whether such vaccines work in humans, in systems where huMUC1 is a self‐antigen.
Natascha, Stergiou, Markus, Glaffig, Helmut, Jonuleit, Edgar, Schmitt, Horst, Kunz   +4 more
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Detection of a Secreted MUC1/SEC Protein by MUC1 Isoform Specific Monoclonal Antibodies

Biochemical and Biophysical Research Communications, 1996
Although MUC1 proteins are known to be secreted by breast cancer cells, the mechanism of their release from the cell is still obscure. Our previously reported MUC1 cDNA sequences suggested the existence of a secreted MUC1 isoform, MUC1/SEC, that includes a sequence of intron 2, and terminates prematurely at a stop codon within this intron.
N, Smorodinsky, M, Weiss, M L, Hartmann, A, Baruch, E, Harness, M, Yaakobovitz, I, Keydar, D H, Wreschner   +7 more
openaire   +2 more sources

MUC1

2013
Olivera Finn, Lixin Zhang
openaire   +1 more source

MUC1

2017
Olivera Finn, Lixin Zhang
openaire   +1 more source

Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents

Cancer Cell, 2004
Jian Ren, Yongqing Li, Wei-Hsuan Yu
exaly  

A review on development of MUC1-based cancer vaccine

Biomedicine and Pharmacotherapy, 2020
Han Lei
exaly  

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer

Cancer Cell, 2017
Surendra K Shukla, Vinee Purohit, Kamiya Mehla   +2 more
exaly  

MUC1

2012
openaire   +1 more source