Results 51 to 60 of about 133,349 (299)
Smoking-associated increase in mucins 1 and 4 in human airways [PDF]
Respiratory Research, 2020 Abstract Rationale Smoking-related chronic obstructive pulmonary disease (COPD) is associated with dysregulated production of mucus. Mucins (MUC) are important both for mucus secretion and epithelial defense. We have examined the distribution of MUC1 and MUC4 in the airway epithelial cells of never-smokers and smokers ...
Merikallio, H. (Heta) +8 more
openaire +5 more sources
A Monoclonal Antibody Against the Oncogenic Mucin 1 Cytoplasmic Domain [PDF]
Hybridoma, 2011 Mucin 1 (MUC1) is a heterodimeric protein that is aberrantly overexpressed in diverse human carcinomas and certain hematologic malignancies. The transmembrane MUC1-C subunit confers tumorigenicity and is a target for anti-cancer drug development. In this regard, the MUC1-C cytoplasmic domain interacts with multiple effectors that have been linked to ...
Govind, Panchamoorthy +4 more
openaire +2 more sources
Lubiprostone stimulates small intestinal mucin release
BMC Gastroenterology, 2012 Background Lubiprostone is a synthetic bicyclic fatty acid derivative of prostaglandin E1 (PGE1) used for chronic constipation. The best known action of lubiprostone is simulation of Cl- dependent fluid secretion.
De Lisle Robert C
doaj +1 more source
Stimulation of hCG protein and mRNA in first trimester villous cytotrophoblast cells in vitro by glycodelin A [PDF]
, 2005 Aim: Human chorionic gonadotropin (hCG) is produced by fetal trophoblast cells and secreted into maternal circulation mainly in the first trimester of pregnancy.
Albanese +19 more
core +1 more source
Incessant Ovulation, Mucin 1 Immunity, and Risk for Ovarian Cancer [PDF]
Cancer Epidemiology, Biomarkers & Prevention, 2007 Abstract Background: Risk for ovarian cancer correlates directly with “ovulatory years or cycles” estimated from time not pregnant, breast-feeding, or using oral contraceptives. Recently, we reported that several factors known to reduce ovarian cancer risk may operate by inducing antibodies against mucin 1 (MUC1), a glycoprotein ...
Kathryn L, Terry +5 more
openaire +2 more sources
Peptidomic and glycomic profiling of commercial dairy products: identification, quantification and potential bioactivities. [PDF]
, 2019 Peptidomics and glycomics are recently established disciplines enabling researchers to characterize functional characteristics of foods at a molecular level.
Barile, Daniela +4 more
core +2 more sources
GABA selectively increases mucin-1 expression in isolated pig jejunum [PDF]
Genes & Nutrition, 2015 The inhibitory neurotransmitter GABA (γ-aminobutyric acid) is synthesized by glutamic acid decarboxylase, which is expressed in the central nervous system and in various other tissues including the intestine. Moreover, GABA can be ingested in vegetarian diets or produced by bacterial commensals in the gastrointestinal tract. As previous studies in lung
Hannah-Sophie Braun +4 more
openaire +2 more sources
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
A role for eosinophils in the intestinal immunity against infective Ascaris suum larvae [PDF]
, 2013 The aim of this study was to explore the mechanisms of resistance against invading Ascaris suum larvae in pigs. Pigs received a low dose of 100 A. suum eggs daily for 14 weeks.
Chiers, Koen +6 more
core +4 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source