Results 31 to 40 of about 116,093,450 (283)

Primary breast cancer biomarkers based on glycosylation and extracellular vesicles detected from human serum

Cancer Reports, 2022
Background Breast cancer is a very common cancer that can be severe if not discovered early. The current tools to detect breast cancer need improvement. Cancer has a universal tendency to affect glycosylation.
Joonas Terävä, Alejandra Verhassel, Orsola Botti, Md. Khirul Islam, Janne Leivo, Saara Wittfooth, Pirkko Härkönen, Kim Pettersson, Kamlesh Gidwani   +8 more
doaj   +1 more source

MUCIN 1 in Prostate Cancer

, 2021
ABSTRACT Despite extensive research efforts in prostate cancer for the last several decades, the disease remains a leading cause of cancer death in men in the developed world. A typical feature of prostate cancer initiation and progression is the landscape of genetic alterations, which changes the expression patterns of numerous molecules in prostate ...
Kapoor A, Gu Y, Lin X, Peng J, Major P, Tang D.   +5 more
europepmc   +3 more sources

Preliminary Development and Testing of C595 Radioimmunoconjugates for Targeting MUC1 Cancer Epitopes in Pancreatic Ductal Adenocarcinoma

Cells, 2022
Mucin 1 is a transmembrane glycoprotein which overexpresses cancer-specific epitopes (MUC1-CE) on pancreatic ductal adenocarcinoma (PDAC) cells. As PDAC is a low survival and highly aggressive malignancy, developing radioimmunoconjugates capable of ...
Ashleigh Hull, Yanrui Li, Dylan Bartholomeusz, William Hsieh, William Tieu, Tara L. Pukala, Alexander H. Staudacher, Eva Bezak   +7 more
doaj   +1 more source

Heterogeneity and persistence length in human ocular mucins [PDF]

, 2002
Atomic force microscopy (AFM) has been used to investigate the heterogeneity and flexibility of human ocular mucins and their subunits. We have paid particular attention, in terms of theory and experiment, to the problem of inducing the polymers to ...
Stoll, S., Corfield, A. P., Round, A. N., Corfield, AP, Corfield, A., Miles, M., Gowers, D., Gowers, DM, Berry, M., Miles, M. J., Stoll, S, McMaster, TJ, McMaster, T., Gowers, Darren, McMaster, T. J., Berry, Monica, Berry, MS, Miles, MJ, Round, A., Round, AN   +19 more
core   +1 more source

Pellicle Modification with Casein and Mucin Does Not Promote In Vitro Bacterial Biofilm Formation. [PDF]

, 2020
PURPOSE During biofilm formation, bacterial species do not attach directly onto the enamel surface, but rather onto the salivary pellicle. Salivary pellicle modification with casein and mucin can hinder erosive demineralisation of the enamel, but it ...
Saads Carvalho, Thiago, Halter, Judith Elisa, Baumann, Tommy, Lussi, Adrian, Muçolli, Dea, Eick, Sigrun   +5 more
core   +1 more source

Mucin 1 expression correlation with lymph node metastasis and micrometastasis and poor prognosis in patients with esophageal squamous cell carcinomas

Archives of Medical Science, 2019
Introduction Lymph node metastasis (LNM) and lymph node micrometastasis (LNMM) are prognostic factors in esophageal squamous cell carcinoma (ESCC) patients.
Fei Yang, Zhe Li, Jing-Bo Shao, Wei Gao, Zhi-Gang Sun   +4 more
doaj   +1 more source

Mucin-degrading gut commensals isolated from healthy faecal donor suppress intestinal epithelial inflammation and regulate tight junction barrier function

Frontiers in Immunology, 2022
The intestinal epithelium surface is covered by a layer of mucus that harbors a complex and dynamic population of bacteria termed gut microbiota. In particular, some gut bacteria have the ability to degrade the mucin glycan for nutritional sources ...
Mingfang Pan, Nilakshi Barua, Margaret Ip, Margaret Ip   +3 more
doaj   +1 more source

Smoking-associated increase in mucins 1 and 4 in human airways [PDF]

Respiratory Research, 2020
Abstract Rationale Smoking-related chronic obstructive pulmonary disease (COPD) is associated with dysregulated production of mucus. Mucins (MUC) are important both for mucus secretion and epithelial defense. We have examined the distribution of MUC1 and MUC4 in the airway epithelial cells of never-smokers and smokers ...
Merikallio, H. (Heta), Kaarteenaho, R. (Riitta), Lindén, S. (Sara), Padra, M. (Médea), Karimi, R. (Reza), Li, C.-X. (Chuan-Xing), Lappi-Blanco, E. (Elisa), Wheelock, Å. M. (Åsa M.), Sköld, M. C. (Magnus C.)   +8 more
openaire   +5 more sources

In Vitro Modelling of Barrier Impairment Associated with Gastro-Oesophageal Reflux Disease (GERD)

Clinical and Experimental Gastroenterology, 2021
Marisa Meloni, Paolo Buratti, Francesco Carriero, Laura Ceriotti VitroScreen, In Vitro Innovation Center, Milan, 20149, ItalyCorrespondence: Laura Ceriotti Via Mosè Bianchi, 103, Milan, 20149, ItalyTel +39 02 89077608Email laura.ceriotti@vitroscreen ...
Meloni M, Buratti P, Carriero F, Ceriotti L   +3 more
doaj  

MUC1 aptamer-tethered H40-TEPA-PEG nanoconjugates for targeted siRNA-delivery and gene silencing in breast cancer cells

Frontiers in Bioengineering and Biotechnology
With a prevalence of 12.5% of all new cancer cases annually, breast cancer stands as the most common form of cancer worldwide. The current therapies utilized for breast cancer are constrained and ineffective in addressing the condition.
Rajesh Salve, Rajesh Salve, Niladri Haldar, Niladri Haldar, Aazam Shaikh, Aazam Shaikh, Rajkumar Samanta, Rajkumar Samanta, Devyani Sengar, Devyani Sengar, Surajit Patra, Surajit Patra, Virendra Gajbhiye, Virendra Gajbhiye   +13 more
doaj   +1 more source