The role of mucin 1 in respiratory diseases [PDF]
European Respiratory Review, 2021 Recent evidence has demonstrated that mucin 1 (MUC1) is involved in many pathological processes that occur in the lung. MUC1 is a transmembrane protein mainly expressed by epithelial and hematopoietic cells.
Beatriz Ballester +2 more
doaj +9 more sources
Mucin-1: a promising pan-cancer therapeutic target [PDF]
npj Precision OncologyMucin1 or MUC1 (also known as CD227, EMA, MCD, MAM6, PEM, PUM, KL-6, CA 27.29/CA 15-3) is a highly glycosylated transmembrane mucin family member protein that is overexpressed in various solid or hematological cancers.
Udhayvir Singh Grewal, Razelle Kurzrock
doaj +4 more sources
Plasma Mucin-1 as a Potential Biomarker for Diabetic Peripheral Neuropathy in Type 2 Diabetes [PDF]
BiomoleculesBackground: Diabetic peripheral neuropathy (DPN) is a major complication of type 2 diabetes mellitus (T2D) that reduces quality of life and increases the risk of foot ulcers and amputations.
Jae-Hyung Park +6 more
doaj +2 more sources
Novel roles for mucin 1 in the kidney [PDF]
Current Opinion in Nephrology and Hypertension, 2017 Recent studies in the kidney have revealed that the well characterized tumor antigen mucin 1 (MUC1/Muc1) also has numerous functions in the normal and injured kidney.Mucin 1 is a transmembrane mucin with a robust glycan-dependent apical targeting signal and efficient recycling from endosomes.
Al-bataineh, Mohammad +2 more
openaire +4 more sources
Polymer stealthing and mucin-1 retargeting for enhanced pharmacokinetics of an oncolytic vaccinia virus [PDF]
Molecular Therapy: Oncolytics, 2021 Vaccinia virus (VV) is a powerful tool for cancer treatment with the potential for tumor tropism, efficient cell-to-cell spread, rapid replication in cancer cells, and stimulation of anti-tumor immunity.
Claudia Hill +9 more
doaj +2 more sources
Bmi-1 regulates mucin levels and mucin O-glycosylation in the submandibular gland of mice.
PLoS ONE, 2021 Mucins, the major components of salivary mucus, are large glycoproteins abundantly modified with O-glycans. Mucins present on the surface of oral tissues contribute greatly to the maintenance of oral hygiene by selectively adhering to the surfaces of ...
Akihiko Kameyama +2 more
doaj +2 more sources
Baseline Blood Levels of Mucin-1 Are Associated with Crucial On-Treatment Adverse Outcomes in Patients with Idiopathic Pulmonary Fibrosis Receiving Antifibrotic Pirfenidone [PDF]
BiomedicinesMucin-1 is a multi-functional glycoprotein expressed by type II alveolocytes and may be detectable in the circulation following pulmonary fibrosis. The prognostic utility of baseline pre-treatment blood levels of mucin-1 in patients with idiopathic ...
Tang-Hsiu Huang +7 more
doaj +2 more sources
Mucin 1 Gene (MUC1) and Gastric-Cancer Susceptibility [PDF]
International Journal of Molecular Sciences, 2014 Gastric cancer (GC) is one of the major malignant diseases worldwide, especially in Asia. It is classified into intestinal and diffuse types. While the intestinal-type GC (IGC) is almost certainly caused by Helicobacter pylori (HP) infection, its role in the diffuse-type GC (DGC) appears limited.
Saeki, Norihisa +2 more
openaire +3 more sources
Steroidal but not embryonic regulation of mucin 1 expression in bovine endometrium. [PDF]
J Reprod Dev, 2021 In cow herd management, inadequate embryo implantation leads to pregnancy loss and causes severe economic losses. Thus, it is crucial to understand the molecular mechanisms underlying endometrial receptivity and subsequent embryo implantation. Transmembrane glycocalyx mucin 1 (MUC1) has a large and highly glycosylated extracellular domain known to ...
Kubota K +4 more
europepmc +5 more sources
Transmembrane Mucin 1 Blocks Fluorescein Ingress to Corneal Epithelium. [PDF]
Invest Ophthalmol Vis Sci, 2022 To determine the role of transmembrane mucins in blocking fluorescein ingress to the corneal epithelium and its deficiency in contributing to corneal fluorescein punctate staining.A dry eye model was established by extirpating lacrimal and Harderian glands in rabbits to correlate the expression of mucins with fluorescein-stained areas on the corneal ...
Sun YC +5 more
europepmc +3 more sources