Results 11 to 20 of about 27,431,650 (340)
Mucin 16, the dimerization copycat of mucin 1?
The FASEB Journal, 2021 Mucin 1 (MUC1), a transmembrane mucin that serves a protective role by inhibiting extracellular pathogens from entering epithelial cells is also implicated in forming cancerous cells through dimer formation. Upon expression and localization in the membrane, MUC1 proteins form cysteine‐dependent homodimers through the juxtamembrane domain CQC motif. The
Robert Murphy, Nicole Butch, Edwin Li
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Regulation of mucin 1 expression and its relationship with oral diseases
Archives of Oral Biology, 2020 The aim of this study is to describe the polymorphic mucin 1 (MUC1), and to provide an overview of the known complex and multiple functions of MUC1 in normal oral mucosa and oral mucosal lesions in compromised situations as well as exploring the challenges associated with the heterogeneous nature of MUC1.
Kashyap, Bina, Kullaa, Arja M
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Mucin 1 deficiency mediates corticosteroid insensitivity in asthma
Allergy, 2018 AbstractBackgroundThe loss of corticosteroid efficacy is an important issue in severe asthma management and may lead to poor asthma control and deterioration of airflow. Recent data indicate that Mucin 1 (MUC1) membrane mucin can mediate corticosteroid efficacy in chronic rhinosinusitis, but the role of MUC1 in uncontrolled severe asthma is unknown ...
Javier Milara +5 more
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Differential expression of mucin 1 and mucin 2 in colorectal cancer
World Journal of Gastroenterology, 2018 To determine tissue expression (mRNA, protein) of two types of mucins [mucin 1 (MUC1) and mucin 2 (MUC2)] in patients with colorectal cancer (CRC).Expression of membrane-bound mucin (MUC1) and secretory mucin (MUC2) in CRC (mRNA, protein) were analyzed in tissue material including fragments of tumors obtained from CRC patients (n = 34), and fragments ...
Kasprzak, Aldona +6 more
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Mucin 1 Inhibits Ferroptosis and Sensitizes Vitamin E to Alleviate Sepsis-Induced Acute Lung Injury through GSK3β/Keap1-Nrf2-GPX4 Pathway. [PDF]
Oxid Med Cell Longev, 2022 Background. Ferroptosis is a nonapoptotic form of programmed cell death, which may be related to the occurrence and development of sepsis‐induced acute respiratory distress syndrome (ARDS)/acute lung injury (ALI).
Wang YM +9 more
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Nuclear epidermal growth factor receptor as a therapeutic target
Exploration of Targeted Anti-tumor Therapy, 2023 Epidermal growth factor receptor (EGFR) is one of the most well-studied oncogenes with roles in proliferation, growth, metastasis, and therapeutic resistance.
Benjamin Atwell +2 more
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Lipids in Health and Disease, 2022 Background Hepatic caveolin-1 (CAV1) is reduced in cholesterol gallstone disease (CGD). Mice with CAV1 deficiency were prone to develop CGD. However, it remains unknown whether restored hepatic CAV1 expression prevents the development of CGD.
Sha Li +5 more
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Theragnostic perspectives of Mucin 1 for oral cancer
Oral Oncology ReportsDharmaraj Senthilkumar +1 more
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Novel roles for mucin 1 in the kidney [PDF]
Current Opinion in Nephrology and Hypertension, 2017 Recent studies in the kidney have revealed that the well characterized tumor antigen mucin 1 (MUC1/Muc1) also has numerous functions in the normal and injured kidney.Mucin 1 is a transmembrane mucin with a robust glycan-dependent apical targeting signal and efficient recycling from endosomes.
Al-bataineh, Mohammad +2 more
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Mucin 1 regulates the hypoxia response in head and neck cancer cells.
Journal of Pharmacological Sciences, 2021 Mucin 1 (MUC1) is a transmembrane glycoprotein that contributes to the cellular response in hypoxic conditions in different carcinomas. We investigated the gene expression pattern of MUCs (1, 2, 4, 5AC, 5B, 6, 15, 16, and 19) in isogenic primary (HN4 and
Kusumawadee Utispan, S. Koontongkaew
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