Results 61 to 70 of about 188,185 (313)

Mucins and their receptors in chronic lung disease

Clinical & Translational Immunology, 2020
There is growing recognition that mucus and mucin biology have a considerable impact on respiratory health, and subsequent global morbidity and mortality.
Emma Denneny, Jagdeep Sahota, Richard Beatson, David Thornton, Joy Burchell, Joanna Porter   +5 more
doaj   +1 more source

Elements of the Endomucin Extracellular Domain Essential for VEGF-Induced VEGFR2 Activity

Cells, 2020
Endomucin (EMCN) is the type I transmembrane glycoprotein, mucin-like component of the endothelial cell glycocalyx. We have previously shown that EMCN is necessary for vascular endothelial growth factor (VEGF)-induced VEGF receptor 2 (VEGFR2 ...
Zhengping Hu, Issahy Cano, Kahira L. Saez-Torres, Michelle E. LeBlanc, Magali Saint-Geniez, Yin-Shan Ng, Pablo Argüeso, Patricia A. D’Amore   +7 more
doaj   +1 more source

Background features in the cytology of pancreatic neoplasms

DEN Open, 2022
Cytology is a useful method for diagnosing pancreatic neoplasms. Although endoscopic ultrasound‐guided fine‐needle aspiration has recently become the mainstream method for the diagnosis of pancreatic neoplasms, pancreatic juice and pancreatic duct ...
Kenichi Hirabayashi, Tsubasa Saika, Naoya Nakamura   +2 more
doaj   +1 more source

Von Willebrand factor A1 domain stability and affinity for GPIbα are differentially regulated by its O-glycosylated N- and C-linker

eLife, 2022
Hemostasis in the arterial circulation is mediated by binding of the A1 domain of the ultralong protein von Willebrand factor (VWF) to GPIbα on platelets to form a platelet plug.
Klaus Bonazza, Roxana E Iacob, Nathan E Hudson, Jing Li, Chafen Lu, John R Engen, Timothy A Springer   +6 more
doaj   +1 more source

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

Mechanistic Insights Into the Cross-Feeding of Ruminococcus gnavus and Ruminococcus bromii on Host and Dietary Carbohydrates

Frontiers in Microbiology, 2018
Dietary and host glycans shape the composition of the human gut microbiota with keystone carbohydrate-degrading species playing a critical role in maintaining the structure and function of gut microbial communities.
Emmanuelle H. Crost, Gwenaelle Le Gall, Jenny A. Laverde-Gomez, Indrani Mukhopadhya, Harry J. Flint, Nathalie Juge   +5 more
doaj   +1 more source

Morphogenetic (Mucin Expression) as Well as Potential Anti-Corona Viral Activity of the Marine Secondary Metabolite Polyphosphate on A549 Cells

Marine Drugs, 2020
The mucus layer of the nasopharynx and bronchial epithelium has a barrier function against inhaled pathogens such as the coronavirus SARS-CoV-2. We recently found that inorganic polyphosphate (polyP), a physiological, metabolic energy (ATP)-providing ...
Werner E. G. Müller, Meik Neufurth, Shunfeng Wang, Rongwei Tan, Heinz C. Schröder, Xiaohong Wang   +5 more
doaj   +1 more source

Novel organisation and regulation of the pic promoter from enteroaggregative and uropathogenic Escherichia coli

Virulence, 2022
The serine protease autotransporters of the Enterobacteriaceae (SPATEs) are a large family of virulence factors commonly found in enteric bacteria. These secreted virulence factors have diverse functions during bacterial infection, including adhesion ...
Munirah M. Alhammadi, Rita E. Godfrey, Joseph O. Ingram, Gurdamanjit Singh, Camilla L. Bathurst, Stephen J.W. Busby, Douglas F. Browning   +6 more
doaj   +1 more source

Advances in Sustainable and Wearable Textile Based Soft Robotics

Advanced Functional Materials, EarlyView.
This Review examines advances in wearable textile‐based soft robotics, focusing on sustainable materials, integrated sensing, and scalable actuation. It discusses manufacturing and system integration across healthcare, assistive robotics, prosthetics, and human–machine interfaces, and highlights key challenges in circular design, including life‐cycle ...
Zahir Abbas, Marzia Dulal, Sophia K. Novoselov, Victoria K. Novoselov, Kostya S. Novoselov, Shaila Afroj, Nazmul Karim   +6 more
wiley   +1 more source

Mucin glycans attenuate the virulence of Pseudomonas aeruginosa in infection

Nature Microbiology, 2019
A slimy, hydrated mucus gel lines all wet epithelia in the human body, including the eyes, lungs, and gastrointestinal and urogenital tracts. Mucus forms the first line of defence while housing trillions of microorganisms that constitute the microbiota1.
Kelsey M. Wheeler, Gerardo Cárcamo-Oyarce, Bradley S. Turner, Sheri Dellos-Nolan, Julia Y Co, S. Lehoux, R. Cummings, D. Wozniak, K. Ribbeck   +8 more
semanticscholar   +1 more source