Results 101 to 110 of about 169,288 (293)

Ultrasound‐Activated Ce(IV)‐Integrated Biomimetic Nanoplatform for Oxygenation‐Reinforced Gas‐Sonodynamic Ferroptosis and cGAS–STING‐Driven Antitumor Immunity

Advanced Science, EarlyView.
A Ce(IV)‐integrated biomimetic nanoplatform coordinates tumor oxygenation, ultrasound‐triggered carbon monoxide release, sonodynamic therapy, ferroptosis amplification, and cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) immune activation.
Mengli Ma, Yingying Wu, Yunjie Wang, Yang Li, Yijia Zhang, Zhibo Zhang, Jinzhi Peng, Xiangyu Wu, Yi Luo, Weijing Zhang, Xin Ye, Weisong Lai, Shengyu Wang, Dan Du, Wengang Li, Nan Zheng, Fanghong Luo, Ting Wu   +17 more
wiley   +1 more source

Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links

Advanced Science, EarlyView.
Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou, Keqing Wang, Junhong Chen, Haoyu Wang, Xinjiang Tan, Xuanlin Huang, Zhiyin Lin, Xun Xu, Xin Jin, Shaoqiao Zhang, Liang Xiao, Yuanqiang Zou, Tao Zhang, Xiaomin Liu   +13 more
wiley   +1 more source

Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation

Advanced Science, EarlyView.
Lipid mesophases provide a versatile platform for colon‐targeted delivery of biotherapeutics, protecting them from degradation while enhancing mucoadhesion and enabling localized, controlled release to the inflamed mucosa after oral or rectal administration. In a DSS‐induced colitis model, this strategy reduced disease activity, inflammatory biomarkers,
Rafaela Gazzi, Tiziana Cremona, Reto Czekalla, Emily Campbell, Marlene Schwarzfischer, Doris Pöhlmann, Vanessa Dobernig, Gerhard Rogler, Michael Scharl, Alessandra Bergadano, Raffaele Mezzenga, Martin Kuentz, Paola Luciani, Simone Aleandri   +13 more
wiley   +1 more source

Mucin-rich and mucin-poor colorectal signet ring cell carcinoma: clinicopathological characteristics and prognostic significance

Background Recent findings suggest that colorectal signet ring cell carcinoma (SRCC) can be categorized into two histological types—mucin-rich and mucin-poor—based on the quantity of extracellular mucin, but the prognostic value and the molecular ...
Mian Chen, Rui Zhong, Yunxing Shi, Liang Huang, Hailing Liu, Fujin Ye, Minyi He, Donglong Xu, Zhanzhen Liu   +8 more
core   +1 more source

Mucin biotinylation - NHS-biotin reagent v2

, 2016
This protocol describes how to attach biotin to Bovine Serum Mucin (BSM). The procedure uses a botin-NHS molecule to attach biotin to amines in the mucin proteins.
Victoria Linderberg
core   +1 more source

Dual‐Dynamically Crosslinked Nanogels Enable Prolonged Ocular Retention for Multimodal Dry Eye Therapy

Advanced Science, EarlyView.
This berberine‐loaded dual‐dynamically crosslinked nanogel integrates tannic acid‐zinc metal‐phenolic networks and carboxymethyl chitosan/aldehyde‐functionalized poly(ethylene glycol) dynamic Schiff base networks, achieving 1‐year colloidal and antioxidant stability, sustained corneal berberine exposure for 24 h to support convenient once‐daily dosing,
Yanru Xin, Sisi Chen, Shengli Huang, Mengqi Huang, Jingyan Zhu, Zijian Wang, Jianliang Shen, Qinxiang Zheng   +7 more
wiley   +1 more source

Acinar‐Derived Organoids Reveal Stage‐Specific Control of Acinar Plasticity

Advanced Science, EarlyView.
An acinar‐derived organoid system maintains adult pancreatic acinar identity ex vivo, converts it along an ordered acinar‐to‐ductal‐like trajectory, and then partially restores it. Each transition carries its own signal requirement, with EGF/EGFR initiating conversion and a staged glucocorticoid–IGF1R switch driving redifferentiation.
Yongfei Hou, Siyu Li, Chunying Li, Zhifan Lin, Dan He, Li Yang, Liping Fu, Qianyue Zhang, Tianping Zhou, Yao Yao, Xiaolei Yin   +10 more
wiley   +1 more source

Targeting Mitochondrial Redox Signaling Promotes Neuroregeneration and Functional Recovery in a Multiple Sclerosis Model

Advanced Science, EarlyView.
Modulation of mitochondrial redox signaling by furapyrrodole activates CYB5R3 and suppresses Notch signaling, unlocking the regenerative potential of endogenous neural progenitor cells. This approach promotes neurogenesis, oligodendrogenesis, and remyelination, thereby improving neuronal function in a mouse model of multiple sclerosis and identifying ...
Yuki Narushima, Joshua Saylor, Shun Saito, Jinyan Zhou, Haruka Kawano, Shehata Anwar, Haruki Oba, Rachel Huezo, Miyu Okano, Haruki Matsuda, Makoto Kawatani, Kaori Honda, Hiroyuki Osada, Yuta Kikuchi, Masahito Ohue, Masami Ishibashi, Takayoshi Arai, Makoto Inoue, Midori A. Arai   +18 more
wiley   +1 more source

Stabilizing Functional Nucleic Acids for Real‐Sample Diagnostics

Angewandte Chemie, EarlyView.
Functional nucleic acids enable programmable real‐sample diagnostics, but often lose function in complex biological matrices. This review highlights four stabilization levers—chemical, topological, architectural, and microenvironment/interface engineering—that preserve aptamer and DNAzyme performance in saliva, serum, urine, and stool, reframing ...
Soyeon Lee, Letizia Dondi, Amal Mathai, Connor Nurmi, Yingfu Li   +4 more
wiley   +2 more sources

Ueber Mucin aus der Sehne des Rindes

, 1886
UEBER MUCIN AUS DER SEHNE DES RINDES Details: Zeitschrift für physiologische Chemie: 1.1877-20.1895 Hoppe-Seyler's Zeitschrift für physiologische Chemie: 21.1895- 112.1921 (-) Zeitschrift für Physiologische Chemie (10) (a0001) Ueber ...
Loebisch, W. F.
core   +2 more sources