Results 101 to 110 of about 188,185 (313)

The Role of Mucin in the Toxicological Impact of Polystyrene Nanoparticles

Materials, 2018
The development of novel oral drug delivery systems is an expanding area of research and both new approaches for improving their efficacy and the investigation of their potential toxicological effect are crucial and should be performed in parallel ...
Iwona Inkielewicz-Stępniak, L. Tajber, G. Behan, Hongzhou Zhang, M. Radomski, Carlos Medina, M. Santos-Martinez   +6 more
semanticscholar   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Study of mucin turnover in the small intestine by in vivo labeling

Scientific Reports, 2018
Mucins are highly glycosylated proteins which protect the epithelium. In the small intestine, the goblet cell-secreted Muc2 mucin constitutes the main component of the loose mucus layer that traps luminal material.
H. Schneider, T. Pelaseyed, Frida Svensson, M. Johansson   +3 more
semanticscholar   +1 more source

Microalgae Hybrid Biosystem for Enhanced Oral Delivery of Rifaximin in Hepatic Encephalopathy Treatment

Advanced Science, EarlyView.
The microalgae‐nanoparticle hybrid system with antibacterial activity can improve the oral delivery and therapeutic efficiency for hepatic encephalopathy treatment. Oral administration of the system can reduced systemic ammonia levels, enhanced intestinal barrier function, attenuated systemic and neuroinflammation, ameliorated cognitive impairments ...
Kaiyue Wang, Xueting Huang, Lingxiao Yang, Jin Liu, Lei Lei, Shaomin Zou, Kai Wang, Min Zhou, Zhe Tang   +8 more
wiley   +1 more source

The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin

Biochemical and Biophysical Research Communications - BBRC, 2017
To understand the mucociliary clearance system, mucins were visualized by light, confocal and electron microscopy, and mucus was stained by Alcian blue and tracked by video microscopy on tracheal explants of newborn piglets. We observed long linear mucus
A. Ermund, L. Meiss, A. M. Rodríguez-Piñeiro, A. Bähr, Harriet E. Nilsson, S. Trillo-Muyo, Caroline Ridley, D. Thornton, J. Wine, H. Hebert, N. Klymiuk, G. Hansson   +11 more
semanticscholar   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

Mucin degradation niche as a driver of microbiome composition and Akkermansia muciniphila abundance in a dynamic gut model is donor independent

FEMS Microbiology Ecology, 2018
Akkermansia muciniphila, an abundant mucin degrading intestinal bacterium, has been correlated with human health in various studies. The in vitro SHIME model was used to reach a mechanistic understanding of A.
Florence Van Herreweghen, Kim De Paepe, H. Roume, F. Kerckhof, Tom Van de Wiele   +4 more
semanticscholar   +1 more source

Exploring the resilience and stability of a defined human gut microbiota consortium: An isothermal microcalorimetric study

MicrobiologyOpen
The gut microbiota significantly contributes to human health and well‐being. The aim of this study was to evaluate the stability and resilience of a consortium composed of three next‐generation probiotics (NGPs) candidates originally found in the human ...
Anna Kattel, Valter Aro, Petri‐Jaan Lahtvee, Jekaterina Kazantseva, Arvi Jõers, Ranno Nahku, Isma Belouah   +6 more
doaj   +1 more source

Structural Identification of O-Linked Oligosaccharides Using Exoglycosidases and MSn Together with UniCarb-DB Fragment Spectra Comparison

Metabolites, 2012
The availability of specific exoglycosidases alongside a spectral library of O-linked oligosaccharide collision induced dissociation (CID) MS fragments, UniCarb-DB, provides a pathway to make the elucidation of O-linked oligosaccharides more efficient ...
Liaqat Ali, Diarmuid T. Kenny, Catherine A. Hayes, Niclas G. Karlsson   +3 more
doaj   +1 more source

Mucins and Their Roles in Asthma

Immunological Reviews
ABSTRACT Mucus is a crucial component of airway host defense. For optimal protection, its chief components—the mucins MUC5AC and MUC5B—need to be tightly regulated. Their expression localizes to specific secretory epithelial cell types capable of producing and secreting massive glycopolymers.
Qihua Ye, Gilda Opoku, Marika Orlov, Ana M. Jaramillo, Fernando Holguin, Eszter K. Vladar, William J. Janssen, Christopher M. Evans   +7 more
openaire   +2 more sources