Results 41 to 50 of about 188,185 (313)

Mucins and the Microbiome [PDF]

Annual Review of Biochemistry, 2020
Generating the barriers that protect our inner surfaces from bacteria and other challenges requires large glycoproteins called mucins. These come in two types, gel-forming and transmembrane, all characterized by large, highly O -glycosylated mucin domains that are diversely decorated by Golgi
openaire   +2 more sources

An enzymatic toolkit for selective proteolysis, detection, and visualization of mucin-domain glycoproteins

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Researchers and clinicians rely on robust staining methods to detect and visualize biomolecules of interest. Mucins are heavily glycosylated proteins expressed on cells throughout the human body that have historically proved challenging to ...
D. J. Shon, Stacy A. Malaker, Kayvon Pedram, Emily Y. Yang, V. Krishnan, O. Dorigo, C. Bertozzi   +6 more
semanticscholar   +1 more source

Advances in the Evaluation of Gastrointestinal Absorption Considering the Mucus Layer

Pharmaceutics, 2023
Because of the increasing sophistication of formulation technology and the increasing polymerization of compounds directed toward undruggable drug targets, the influence of the mucus layer on gastrointestinal drug absorption has received renewed ...
Kaori Miyazaki, Akira Sasaki, Hiroshi Mizuuchi   +2 more
doaj   +1 more source

Defensive Properties of Mucin Glycoproteins during Respiratory Infections—Relevance for SARS-CoV-2

mBio, 2020
Mucus plays a pivotal role in protecting the respiratory tract against microbial infections. It acts as a primary contact site to entrap microbes and facilitates their removal from the respiratory tract via the coordinated beating of motile cilia.
M. Chatterjee, J. V. van Putten, K. Strijbis   +2 more
semanticscholar   +1 more source

Gut microbiota metabolite indole-3-acetic acid maintains intestinal epithelial homeostasis through mucin sulfation

Gut microbes
The global incidence and prevalence of inflammatory bowel disease (IBD) are gradually increasing. A high-fat diet (HFD) is known to disrupt intestinal homeostasis and aggravate IBD, yet the underlying mechanisms remain largely undefined. Here, a positive
Mengfan Li, Yiyun Ding, Jingge Wei, Yue Dong, Jingyi Wang, Xin Dai, Jingchun Yan, F. Chu, Kexin Zhang, Fanyi Meng, Jiahui Ma, Weilong Zhong, Bangmao Wang, Yunhuan Gao, Rongcun Yang, Xinjuan Liu, Xiaomin Su, Hailong Cao   +17 more
semanticscholar   +1 more source

Reduced colonic mucin degradation in breastfed infants colonized by Bifidobacterium longum subsp. infantis EVC001

FEBS Open Bio, 2018
Mucin glycoproteins play an important role in protecting the gut epithelium by keeping gut microbes from direct contact with the gut epithelium while allowing for diffusion of small molecules from the lumen to the epithelium.
Sercan Karav, Giorgio Casaburi, Steven A. Frese   +2 more
doaj   +1 more source

Steroidal but not embryonic regulation of mucin 1 expression in bovine endometrium

The Journal of Reproduction and Development, 2021
In cow herd management, inadequate embryo implantation leads to pregnancy loss and causes severe economic losses. Thus, it is crucial to understand the molecular mechanisms underlying endometrial receptivity and subsequent embryo implantation ...
Kaiyu KUBOTA, Masafumi MIWA, Ken-Go HAYASHI, Misa HOSOE, Miki SAKATANI   +4 more
doaj   +1 more source

Microlithiasis: an important cause of ‘idiopathic’ acute pancreatitis?

Annals of Hepatology, 2003
Microlithiasis is the underlying cause in a significant proportion of patients with ‘idiopathic’ acute pancreatitis. The mechanism appears to be a relative deficiency of phosphatidylcholine in bile, with fast and extensive cholesterol crystallization as ...
Niels G. Venneman, Sigrid E. van Brummelen, Gerard P. van Berge-Henegouwen, Karel J. van Erpecum, MD, PhD   +3 more
doaj   +1 more source

Lentinan -triggered butyrate-producing bacteria drive the expulsion of the intestinal helminth Trichinella spiralis in mice

Frontiers in Immunology, 2022
Trichinellosis caused by Trichinella spiralis is a serious zoonosis with a worldwide distribution. Lentinan (LNT) is known to modulate the intestinal environment with noted health benefits, yet the effect of LNT against intestinal helminth is unknown. In
Xuemin Jin, Yi Liu, Isabelle Vallee, Gregory Karadjian, Mingyuan Liu, Mingyuan Liu, Xiaolei Liu   +6 more
doaj   +1 more source

Binding of Akkermansia muciniphila to mucin is O-glycan specific

Nature Communications
The intestinal anaerobic bacterium Akkermansia muciniphila is specialized in the degradation of mucins, which are heavily O-glycosylated proteins that constitute the major components of the mucus lining the intestine.
Janneke Elzinga, Yoshiki Narimatsu, Noortje de Haan, Henrik Clausen, Willem M. de Vos, Hanne L. P. Tytgat   +5 more
semanticscholar   +1 more source