Results 121 to 130 of about 191,997 (296)

Histopathological and ultrastructural evaluations of giant African snail (Achatina fulica) mucin and alginate hydrogel on cutaneous wound healing in rats

Open Veterinary Journal
Background: Wound healing is a complex biological process that involves inflammation, cellular proliferation, and tissue remodeling. Efficient and prompt wound repair is critical for infection prevention and tissue integrity restoration.
Mohammad Reza Salahi, Mohammad Mahdi Molaei, Shahrzad Azizi, Pourya Mohammadi, Maziar Jajarmi   +4 more
doaj   +1 more source

Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells

Advanced Science, EarlyView.
This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh, Payel Bhanja, Emily Schueddig, Jufri Setianegara, Yuting Lin, Kenny Guida, Shujah Rehman, Stacey Krepel, Devin Koestler, Ronald C. Chen, Katherine L. Cook, Subhrajit Saha   +11 more
wiley   +1 more source

Follicular Adenoma with Extensive Extracellular Mucin Deposition: Report on Two Cases

Clinical Medicine Insights: Case Reports, 2012
We report two cases of follicular adenoma of the thyroid with extensive extracellular mucin deposition. Fine needle aspiration in Case 1 showed singly discohesive polygonal cells in a granular mucinous background.
Na Rae Kim, Hyun Yee Cho, Sergio Piña-Oviedo, Gustavo De La Roza, Young Don Lee, Jae Y. Ro   +5 more
doaj   +1 more source

Gastrointestinal endogenous proteins as a source of bioactive peptides : Doctor of Philosophy in Nutritional Sciences at Riddet Institute, Massey University, Palmerston North, New Zealand [PDF]

, 2016
Gastrointestinal endogenous proteins (GEP) were investigated as a source of bioactive peptides. In silico and in vitro methods were used singly or in combination to study GEP-derived peptides after simulated digestion.
Acharya, Prasannalakshmi
core  

Mucin 1-mediated chemo-resistance in lung cancer cells

Oncogenesis, 2016
AbstractPaclitaxel (PTX) is a commonly used drug to treat diverse cancer types. However, its treatment can generate resistance and the mechanisms of PTX-resistance in lung cancers are still unclear. We demonstrated that non-small cell lung cancers (NSCLCs) survive PTX treatment.
Ham, S. Y., Kwon, T., Bak, Y., Yu, H., Hong, J., Lee, S. K., Yu, D-Y, Yoon, D-Y   +7 more
openaire   +3 more sources

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

IGFBP5 Restores Endometrial Receptivity and Rescues Implantation Failure in Polycystic Ovary Syndrome

Advanced Science, EarlyView.
Impaired endometrial receptivity contributes to the poor pregnancy outcomes in women with PCOS. The authors found that decreased endometrial IL‐22 levels and disrupted STAT3‐IGFBP5 signaling pathway contributed to impaired endometrial receptivity. Supplementation with IL‐22 or IGFBP5 exerts a protective effect on implantation failure in PCOS‐like mice,
Baoying Liao, Chuyu Yun, Hongying Shan, Yuqian Wang, Xiunan Chen, Weisi Lian, Tianliu Peng, Min Zhao, Xunsi Qin, Kailun Hu, Ping Zhou, Yue Wang, Yanli Pang, Rong Li   +13 more
wiley   +1 more source

Hybrid CaCO3-mucin crystals: Effective approach for loading and controlled release of cationic drugs

Materials & Design, 2019
Vaterite CaCO3 crystals are actively used as a biocompatible and degradable matrix for encapsulation of fragile biomacromolecules. However, the incorporation of small cationic drugs into the crystals remains awkward due to a poor binding of these drugs ...
Nadezhda G. Balabushevich, Ekaterina A. Kovalenko, Irina M. Le-Deygen, Lyubov Y. Filatova, Dmitry Volodkin, Anna S. Vikulina   +5 more
doaj   +1 more source

Genetic Control of Tissue Remodeling by a Non‐Coding SNP in ITGA8 Explains Carotenoid‐Based Color Polymorphism in Marine Mollusks

Advanced Science, EarlyView.
In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei, Wenzhu Peng, Zekun Huang, Bingye Yang, Yiyu Wu, Minzhen Han, Yi Wang, Bingling Peng, Guosheng Hu, Jiawei Hong, Guijia Liu, Linwei Nie, Yang Gan, Miaoqin Huang, Xuan Luo, Weiwei You, Wen Liu, Caihuan Ke   +17 more
wiley   +1 more source

Mucin 1 Regulates KIM‐1 Function Following Ischemic Renal Injury

The FASEB Journal, 2019
Kidney injury molecule‐1 (KIM‐1) is a type I transmembrane glycoprotein that is rapidly induced after kidney injury in the proximal tubule (PT). The ectodomain of KIM‐1 is cleaved by a disintegrin and metalloproteinase domain 17 (ADAM17) and thereby constitutively shed into the urine providing a sensitive biomarker for kidney injury.
Mohammad Al‐bataineh, Carol Kinlough, Zaichuan Mi, Edwin Jackson, Rebecca Hughey   +4 more
openaire   +1 more source