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The FASEB Journal, 2020
Mucin 1 (MUC1) is a large, heavy O‐glycosylated mucin glycoprotein with a molecular weight of 250 to 500 kDa, depending on the level of glycosylation, and extends 200–500 nm from the cell surface. MUC1 spans the cell membrane at the apical surface of normal simple epithelia and the surfaces of some ...
Tina Link +6 more
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Mucin 1 (MUC1) is a large, heavy O‐glycosylated mucin glycoprotein with a molecular weight of 250 to 500 kDa, depending on the level of glycosylation, and extends 200–500 nm from the cell surface. MUC1 spans the cell membrane at the apical surface of normal simple epithelia and the surfaces of some ...
Tina Link +6 more
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Galectin-1 binds mucin in human trophoblast
Histochemistry and Cell Biology, 2014Mucins are multifunctional highly glycosylated proteins expressed by the female reproductive tract. Differential expression of MUC1 and MUC15 has been shown in trophoblast. This study was undertaken to establish the distribution of mucin(s) in cytotrophoblast cell cultures using anti-bovine submaxillary mucin (BSM) and to investigate the possibility of
Zanka, Bojić-Trbojević +6 more
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MUC‐1 mucin expression in invasive areas of intraductal papillary mucinous tumors of the pancreas
Pathology International, 1998The expression of MUC‐1 mucin (membrane‐associated mucin) and MUG2 much (secretory mucin) were immunohistochemically examined in 46 invasive ductal carcinomas (IDC) and 16 intraductal papillary mucinous tumors (IPMT) of the pancreas. lntraductal papillary mucinous tumors usually reveal expansive growth.
S, Yonezawa +11 more
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Advances in the Applications of Mucin 1 in Cancer Therapy
Journal of Biomedical Nanotechnology, 2023Mucin 1 belongs to the membrane-binding mucoprotein subfamily, which is normally a highly O-glycosylated polymer protein that is mainly expressed in epithelial cells and some hematopoietic cells. Mucin 1 was overexpressed in many cancer tissues compared to normal tissue with a lower degree of glycosylation.
Ben Yang +13 more
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Mucin 1 deficiency mediates corticosteroid insensitivity in asthma
Allergy, 2018AbstractBackgroundThe loss of corticosteroid efficacy is an important issue in severe asthma management and may lead to poor asthma control and deterioration of airflow. Recent data indicate that Mucin 1 (MUC1) membrane mucin can mediate corticosteroid efficacy in chronic rhinosinusitis, but the role of MUC1 in uncontrolled severe asthma is unknown ...
Javier Milara +5 more
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Adherence of Shigella dysenteriae 1 to Human Colonic Mucin
Current Microbiology, 2001The pathogenic potential of Shigella is correlated with the ability of the organism to invade and multiply within the cells of colonic epithelium. Although invasion is the ultimate event, a preceding step is adherence. Shigella dysenteriae 1 preferentially adhered to colonic mucin and not to small intestinal mucin.
P S, Sudha, H, Devaraj, N, Devaraj
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Role of Mucin 1 and Glycodelin A in recurrent implantation failure
Fertility and Sterility, 2015To evaluate and compare the levels of Mucin 1 (MUC-1) and Glycodelin A (GdA) in precisely timed endometrial biopsies and blood samples taken from women with recurrent implantation failure, and women with proven fertility, in a control group.Molecular studies in human blood and tissue.University hospital.Women with recurrent implantation failure and ...
Ercan Bastu +7 more
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A clinical appraisal of stage 1 mucinous carcinoma of the ovary
Gynecologic Oncology, 1989Thirty patients with stage I mucinous carcinoma of the ovary are reviewed with special reference to possible prognostic factors. The role of adjuvant therapy is discussed. Adjuvant therapy is recommended only for patients with poorly differentiated tumours and with stage Ic disease.
R, Soeters +4 more
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Update on Mucin-1 immunotherapy in cancer: a clinical perspective
Expert Opinion on Biological Therapy, 2015Mucin 1 (MUC1) is particularly well suited as a cancer immunotherapy target due to the elevated protein expression and aberrant forms associated with malignancy. A variety of therapeutic strategies have been explored, including antibodies intended to induce cancer cell destruction, and vaccinations with peptides, tumor extracts, and gene expression ...
Gareth, Rivalland +2 more
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