Results 121 to 130 of about 40,863 (293)

Protein tyrosine phosphatases as emerging targets for cancer immunotherapy

British Journal of Pharmacology, EarlyView.
Abstract Contemporary strategies in cancer immunotherapy, despite remarkable success, remain constrained by inherent limitations such as suboptimal patient responses, the emergence of drug resistance, and the manifestation of pronounced adverse effects. Consequently, the need for alternative strategies for immunotherapy becomes clear.
Zihan Qu, Jiajun Dong, Zhong‐Yin Zhang
wiley   +1 more source

Mucinous Adenocarcinoma of the Tongue in a Great Horned Owl

, 1985
Dirck L. Dillehay, Trenton R. Schoeb, G. S. Ranglack   +2 more
openalex   +1 more source

Impact of TP53, KRAS, and APC Mutations on Neoadjuvant Chemotherapy Outcomes in Locally Advanced Rectal Cancer

Cancer Science, EarlyView.
Genetic profiling of TP53, KRAS, and APC mutations reveals potential as predictors of neoadjuvant chemotherapy efficacy in locally advanced rectal cancer, aiding personalized treatment strategies to improve survival and reduce recurrence risks. ABSTRACT Despite recent advances in neoadjuvant strategies for locally advanced rectal cancer (LARC), optimal
Tomohiro Takeda, Tatsuya Shonaka, Mishie Tanino, Katsuro Enomoto, Shoichiro Mizukami, Masahide Otani, Mizuho Ohara, Chikayoshi Tani, Kimiharu Hasegawa, Takahiro Ishii, Ayumu Sugitani, Chiho Maeda, Yusuke Ono, Yuji Uno, Nobue Tamamura, Shin‐ichi Chiba, Yusuke Mizukami, Hideki Yokoo   +17 more
wiley   +1 more source

VRK1 Is a Novel Therapeutic Target for Small Cell Neuroendocrine Carcinoma of the Cervix

Cancer Science, EarlyView.
Small cell neuroendocrine carcinoma of the cervix (SCNEC), a rare but aggressive cancer, consistently exhibited high VRK1 expression. VRK1 knockdown significantly suppressed xenograft tumor growth by inducing mitochondrial dysfunction. These findings highlighted VRK1 as a potential therapeutic target for SCNEC.
Mariya Kobayashi, Satoshi Nakagawa, Yusuke Ishii, Yuji Kamei, Mizuki Kanda, Tatsuo Masuda, Mamoru Kakuda, Kosuke Hiramatsu, Tadashi Iwamiya, Tomomi Egawa‐Takata, Shinya Matsuzaki, Hiroyuki Uematsu, Kunishige Onuma, Masahiro Inoue, Yutaka Ueda, Tadashi Kimura, Michiko Kodama   +16 more
wiley   +1 more source

Comparison of clinicopathological features and prognostic analysis between early-onset and late-onset advanced rectal mucinous adenocarcinoma

结直肠肛门外科
[Objectives] To compare the clinicopathological features with early-onset and late-onset advanced rectal mucinous adenocarcinoma and analysis the prognosis.
Du Rui, Chang Yue, Li Yonghai, Cheng Yuanguang, Zhang Juan, Zhang Chengyue, Xu Liejuan, Liu Yuancheng   +7 more
doaj   +1 more source

A case of mucinous adenocarcinoma of the endometrium.

, 1987
Megumi Yoshida, Yoji Kusuyama, Hideaki Imai, Taro Hosomichi, Yoshiya Mabuchi, Hideo Yokota, Yozo Nishi   +6 more
openalex   +2 more sources

Gasdermins: multifunctional effectors of membrane permeabilization across cellular compartments

The FEBS Journal, EarlyView.
Gasdermins (GSDMs) are pore‐forming proteins best known for driving pyroptosis through plasma membrane (PM) permeabilization. Beyond triggering inflammatory cell death, GSDMs can also associate with organelle membranes, including mitochondria, lysosomes, ER, and nucleus, where they modulate membrane integrity and cellular signaling.
Eleonora Margheritis, Nadine Gehle, Katia Cosentino   +2 more
wiley   +1 more source

A Case of Mucinous Adenocarcinoma of the Duodenal Bulb.

, 1991
Makoto Sasaki, Tohru Oshibuchi, Hiroaki Hamasaki, Masahiro Fujimoto, Yoshinori Kajiwara, Shigetoshi Matsuo, Tsukasa Tsunoda   +6 more
openalex   +2 more sources

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Mucinous adenocarcinoma of the prostate. A case report.

, 1994
Atsushi Nakamura, Katsumi Kobayashi, Masaru Taniguchi, Masayuki NOZAKI, Yuichiro Fukazawa   +4 more
openalex   +2 more sources