Results 151 to 160 of about 176,444 (236)

The molecular pathological basis and potential clinical applications of ‘zero‐budding’ status in stage II colorectal cancer

The Journal of Pathology: Clinical Research, Volume 12, Issue 6, November 2026.
Abstract In the personalized management of stage II colorectal cancer (CRC), traditional TNM (Tumor, Node, Metastasis) staging has limited ability to accurately stratify the risk of postoperative recurrence. Consequently, oncologists frequently face a major therapeutic dilemma when determining the use of adjuvant chemotherapy in these patients ...
Ying‐nan Liu, Ben Wang, Qian Xu
wiley   +1 more source

Primary vs. Metastatic Mucinous Adenocarcinoma of the Skin: a Case Report and Discussion of Immunohistochemical Techniques

, 2011
Paper presented to the 7th Annual Symposium on Graduate Research and Scholarly Projects (GRASP) held at the Marcus Welcome Center, Wichita State University, May 4, 2011.Research completed at the Department of Physician AssistantBackground: Primary ...
Schettle, Lidia S.
core  

Association of High‐Grade Components < 20% on DFS in Stage I Lung Adenocarcinoma: A Real‐World Study of Risk Analysis and Predictive Nomogram Development

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Objective To assess whether high‐grade components occupying < 20% of the tumor have prognostic value and whether an Adjusted Grade nomogram improves risk stratification in Stage I invasive lung adenocarcinoma (LUAD). Methods We retrospectively analyzed 1539 patients with pathologically confirmed Stage I invasive LUAD undergoing R0 resection ...
Shuhao Liang, Xuanpeng Wu, Tao Jiang, Ming Ni, Fei Xue, Chenxi Li, Tianhao Chen, Leyu Hong, Chao Luo, Qifei Wu   +9 more
wiley   +1 more source

Mechanistic Study of GSDME and CXCL10 in SUV39H1‐Mediated Pyroptosis and Immune Suppression in Cervical Cancer

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Cervical cancer (CC) remains a major global health challenge characterized by high incidence and mortality. The histone methyltransferase suppressor of variegation 3–9 homolog 1 (SUV39H1) has emerged as a key epigenetic regulator in tumor progression, but its role in modulating pyroptosis and remodeling of the immune microenvironment in CC ...
Li Zhang, Peiting Sheng, Dongge Cai, Ziyue Zhao, Xiaoling Wu, Yan'e Gao   +5 more
wiley   +1 more source

Successful Resection of Transverse Colon Cancer Invading a Reconstructed Jejunum After Pancreaticoduodenectomy: A Case Report

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT The treatment of locally advanced colon cancer is surgically challenging, particularly in patients with prior pancreaticoduodenectomy. Careful assessment after neoadjuvant chemotherapy may enable curative resection while preserving pancreaticobiliary reconstruction.
Kohei Oyamada, Masaya Hiyoshi, Kotaro Nishida, Takayuki Okuno, Hiroshi Kawasaki, Yusuke Kyoden   +5 more
wiley   +1 more source

The microbiome and brain metastasis in non‐small cell lung cancer: A graded appraisal and a framework for prevention‐oriented research

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
This Review proposes a microbiome–premetastatic brain niche axis connecting gut, lung, and intratumoral microbes with metabolites, blood–brain barrier remodeling, neuroimmune priming, and brain metastasis in NSCLC. It integrates current evidence while distinguishing established mechanisms from associations and hypotheses requiring prospective and ...
Long Liang, Fangjuan Hu, Xiaofeng Wang, Chunhan Tang, Chun Wang, Gefei Jiang, Chungang Zhao, Yin Zhang, Churong Li   +8 more
wiley   +1 more source

Immune Markers and Risk of Pancreatic Cancer in the European EPIC Cohort

International Journal of Cancer, Volume 159, Issue 9, Page 2146-2157, 1 November 2026.
The immune system has been implicated as a major driver in pancreatic cancer etiology. Previous cohort studies have found associations between pancreatic cancer and single immune system‐derived markers, but omics‐based evidence remains scarce. In this prospective case–control study, the authors investigated 92 proteins involved in immune reactions and ...
Verena A. Katzke, Yue Chen, Srimanti Dutta, Federico Canzian, Julie Louise Munk Andersen, Agnetha Linn Rostgaard‐Hansen, Léa Bouteille, Vinciane Rebours, Thérèse Truong, Matthias B. Schulze, Benedetta Bendinelli, Valeria Pala, Vittorio Simeon, Rosario Tumino, Carlotta Sacerdote, Roel Vermeulen, P. Martijn Kolijn, Sjoerd G. Elias, Marta Crous‐Bou, Maria‐José Sánchez, Ana Jimenez‐Zabala, José María Huerta, Marcela Guevara, Nick Wareham, Marie Breeur, Mattias Johansson, James Yarmolinsky, Daniele Campa, Rudolf Kaaks   +28 more
wiley   +1 more source

Metastatic Urachal Carcinoma With Microsatellite Stability and Low Tumor Mutational Burden Achieving a Durable Response to Pembrolizumab After Platinum Failure

IJU Case Reports, Volume 9, Issue 6, November 2026.
ABSTRACT Introduction Urachal carcinoma is a rare and aggressive malignancy with no established systemic therapy after platinum failure. Evidence for immune checkpoint inhibitors (ICIs) remains limited, particularly in tumors without established favorable biomarkers such as microsatellite instability‐high status or high tumor mutational burden.
Fumihiro Ito, Koki Kobayashi, Gaku Hayashi, Shunsuke Kamijo, Takashi Fujita   +4 more
wiley   +1 more source

A Fatal Case of Pulmonary Tumor Thrombotic Microangiopathy Originating From Primary Bladder Adenocarcinoma

IJU Case Reports, Volume 9, Issue 6, November 2026.
ABSTRACT Introduction Pulmonary tumor thrombotic microangiopathy is a rare, fatal complication of malignancy, with few reports involving bladder cancer. Case Presentation An 81‐year‐old man with chronic obstructive pulmonary disease presented with hematuria and progressive exertional dyspnea.
Hiroki Kodani, Yosuke Sekii, Yohei Inoguchi, Eisuke Tomiyama, Hitoshi Takayama, Yumiko Yasuhara   +5 more
wiley   +1 more source

Colonic Barrier Dysfunction and Inflammation Induced by Nano‐/Micro‐Plastics Fibers in Mice via the FAK/NF‐κB/iNOS and TLR4/NF‐κB/iNOS Pathways

Journal of Applied Toxicology, Volume 46, Issue 11, Page 4144-4159, November 2026.
ABSTRACT As emerging environmental contaminants, nano‐ and micro‐plastics (NMPs) have drawn increasing research attention due to potential hazards to organisms. Particle shape is a key factor influencing the toxic effects of NMPs, and NMPs of different shapes cause varying degrees of tissue damage. We investigated the specific mechanisms of polystyrene
Yuting Li, Shibo Bao, Puyang Huang, Jiahui Wang, Hongfeng Li, Yahong Liu, Kai Wang, Jianjun Du, Lingjun Yan, Guowei Pan, Wei Sun   +10 more
wiley   +1 more source