Results 161 to 170 of about 40,863 (293)

Carrier‐Free Nanocapsule with Dual‐Target Capacity for Synergistically Restoring Inflammatory Microenvironment and Microbiota Dysbiosis in Colitis

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This manuscript presents a carrier‐free nanomedicine PCNPs@PEG‐Man with dual‐targeting for IBD. It resists harsh intestinal conditions, reduces oxidative stress, enhances drug uptake and retention, modulates inflammation, and reshapes gut microbiota, offering a safe and effective IBD therapy.
Yingjie Chen, Yuhan Gao, Kaiyuan Huo, Zhaofan Jin, Wenchao Wang, Xingjie Zan, Yanlong Liu, Limeng Zhu, Jianfeng Yang   +8 more
wiley   +1 more source

Nrf2 Drives Epigenetic Reprogramming and Acts as the Master Regulator of KLF4 Expression and Activity in Arsenic‐Induced Transformation

Advanced Science, Volume 12, Issue 40, October 27, 2025.
Nrf2 isn't just a protector—it's a driver of cancer stemness. The study uncovers how arsenic‐activated Nrf2 directly upregulates KLF4, a key pluripotency factor, fueling oncogenic reprogramming. Through enhancer activation and self‐reinforcing loop, Nrf2 and KLF4 co‐opt gene networks linked to epithelial‐to‐mesenchymal transition and tumor growth ...
Ziwei Wang, Zhuoyue Bi, Jessica Bamrah, Yiran Qiu, Wenxuan Zhang, Bandar Saeed Almutairy, Haoyan Ji, John D. Haley, Chitra Thakur, Fei Chen   +9 more
wiley   +1 more source

The TET3/GATA6 Axis Drives Lipid Metabolism and Therapeutic Vulnerabilities in Pancreatic Ductal Adenocarcinoma

Advanced Science, Volume 12, Issue 37, October 6, 2025.
The DNA demethylase TET3 drives lipid metabolic reprogramming in pancreatic ductal adenocarcinoma via a non‐catalytic mechanism. TET3 recruits histone deacetylases to repress GATA6, sustaining lipogenic enzyme expression and ferroptosis resistance.
Shuai Liu, Shaobo Kang, Na Lin, Wenqi Zhang, Shiwen Wang, Yuqing Ren, Xiaofan Ding, Jianxiu Yu, Ruiyu Xie   +8 more
wiley   +1 more source

Progastrin Promotes Colorectal Cancer Stem Cell‐Like Properties via the Receptor PZR

Advanced Science, Volume 12, Issue 38, October 13, 2025.
The tumor microenvironment supports colorectal cancer (CRC) progression by maintaining cancer stem cells (CSCs) through progastrin (PG). This study identifies Protein Zero‐Related protein (PZR) as an essential receptor for PG activity, promoting CSC‐like signaling via SHP2/SRC/β‐catenin.
Julie Nguyen, Marie Lafitte, Maud Barbery, Kevin Espie, Maya Jeitany, Romain Larive, Jihane Vitre, Conception Paul, Yvan Boublik, Elise Fourgous, Valérie Simon, Audrey Sirvent, Madeline Neiveyans, Steeve Thirard, Lucile Bansard, Morgan Maillard, Nathalie Coutry, Jacques Colinge, Philippe Jay, Pierre Martineau, Michael Hahne, Julie Pannequin, Serge Roche   +22 more
wiley   +1 more source

MRI‐Derived Lymph Nodes Morphological and Topological Structure (LNs‐MTS) Model for Evaluating Immune Status and Prognosis in Rectal Cancer

Advanced Science, Volume 12, Issue 39, October 20, 2025.
An MRI‐derived Lymph Nodes morphological and topological structure (LNs‐MTS) model is established to evaluate the immune status of the lymph node system in rectal cancer. It provides a non‐invasive, quantitative approach for prognosis assessment and optimizing adjuvant therapy decisions.
Yunxiao Liu, Liwen Zhang, Yanfen Cui, Weiyuan Zhang, Hanqing Hu, Shuai Jiao, Jian Ma, Jiale Li, Jun Xiang, Jinna Li, Haiyi Liu, Xiaotang Yang, Jie Tian, Xishan Wang, Guiyu Wang, Xu Guan   +15 more
wiley   +1 more source

Bladder metastases of appendiceal mucinous adenocarcinoma: a case presentation [PDF]

, 2010
Gianluigi Taverna, Matteo Corinti, Piergiuseppe Colombo, Fabio Grizzi, Mauro Severo, Alessando Piccinelli, Guido Giusti, Alessio Benetti, Paolo Andrea Zucali, Cinzia Iotti   +9 more
openalex   +1 more source

Clinical course of a tailgut cyst transformed to retrorectal mucinous adenocarcinoma: A case report. [PDF]

Int J Surg Case Rep
Ajredini M, Saracoglu C, Kus AA, Cetin SE, Aytac E, Ozer L.   +5 more
europepmc   +1 more source

Rapidly growing poorly differentiated adenocarcinoma of pancreatic remnant after resection of intraductal papillary-mucinous neoplasm (IPMN)

, 2005
Kenji Yamao, Yasuhiro Shimizu, Nobumasa Mizuno, Kuniyuki Takahashi, Akira Sawaki, Akio Yanagisawa   +5 more
openalex   +2 more sources

Resection of Mucinous Lung Adenocarcinoma Presenting with Intractable Bronchorrhea [PDF]

, 2010
Motoshi Takao, Takehiro Takagi, Hitoshi Suzuki, Akira Shimamoto, Shuichi Murashima, Osamu Taguchi, Hideto Shimpo   +6 more
openalex   +1 more source

Akkermansia muciniphila‐Derived N‐Acetylspermidine Modulates the Localization of Intestinal α1,2‐Fucosylated Proteins to Maintain Gut Homeostasis

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This study demonstrates that Akkermansia muciniphila alleviates colitis by enhancing intestinal α1,2‐fucosylation through its metabolite N‐acetylspermidine. Mechanistically, N‐acetylspermidine‐induced PIM1 inhibition promotes HDAC2‐mediated reduction of chromatin accessibility at TP73, thereby upregulating C1GALT1C1 to boost α1,2‐fucosylation.
Ye Yao, Zhangming Pei, Yuanyuan Dai, Yinghan Chen, Zepeng Chang, Hongchao Wang, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wenwei Lu, Wei Chen   +10 more
wiley   +1 more source