Results 71 to 80 of about 382,234 (365)

Pancreatic cysts suspected to be branch duct intraductal papillary mucinous neoplasm without concerning features have low risk for development of pancreatic cancer. [PDF]

, 2015
BackgroundThe risk of developing pancreatic cancer is uncertain in patients with clinically suspected branch duct intraductal papillary mucinous neoplasm (BD-IPMN) based on the "high-risk stigmata" or "worrisome features" criteria proposed in the 2012 ...
Fehmi, Syed A, Giap, Andrew Q, Gonzalez, Ingrid, Hunt, Gordon C, Krinsky, Mary L, Kwong, Wilson T, Lawson, Robert D, Savides, Thomas J, Slezak, Jeff, Tang, Raymond S   +9 more
core   +1 more source

A novel methodology for in vivo endoscopic phenotyping of colorectal cancer based on real-time analysis of the mucosal lipidome: a prospective observational study of the iKnife [PDF]

, 2016
Background: This pilot study assessed the diagnostic accuracy of rapid evaporative ionization mass spectrometry (REIMS) in colorectal cancer (CRC) and colonic adenomas. Methods: Patients undergoing elective surgical resection for CRC were recruited at St.
Alexander, J, Balog, J, Darzi, A, Gildea, L, Goldin, R, Hoare, J, Kinross, J, Kontovounisios, C, McKenzie, J, Muirhead, L, Nicholson, J, Rasheed, S, Scott, A, Speller, A, Takats, Z, Teare, J, Tekkis, P, Veselkov, K   +17 more
core   +1 more source

A Mucinous Adenocarcinoma of the Duodenum

The Japanese Journal of Gastroenterological Surgery, 2011
症例は79歳女性で，他医で上部消化管内視鏡検査を施行したところ十二指腸潰瘍を指摘されたため同院でプロトンポンプ阻害薬を処方の上経過観察されていた．約8か月後，貧血が指摘され上部消化管内視鏡を再検したところ十二指腸球部潰瘍浸潤型病変が認められ，生検にて腺癌と診断された．腫瘍は幽門輪前部大彎側への浸潤を伴う十二指腸球部下面を主座とする直径約40mmの3型病変であった．十二指腸球部癌の診断で膵頭十二指腸切除術を施行した．病理組織学的に腫瘍はムチンを多く含む粘液癌であり，粘液染色でMUC5AC，MUC6陽性，MUC2陰性の胃型形質を有していた．十二指腸球部癌はまれな疾患であるが，その中でも粘液癌は極めてまれであり報告する．
Takuji Yamada, Osamu Miura, Masakazu Yamamoto, Keisuke Matsuzaki, Toyokazu Kawano   +4 more
openaire   +2 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Determining the date of diagnosis – is it a simple matter? The impact of different approaches to dating diagnosis on estimates of delayed care for ovarian cancer in UK primary care [PDF]

, 2009
Background Studies of cancer incidence and early management will increasingly draw on routine electronic patient records. However, data may be incomplete or inaccurate.
A Majeed, A Rosemary Tate, A Verdecchia, AB Ryerson, Alexander GR Martin, B Rachet, B Yawn, BA Goff, BA Goff, BA Goff, CR Bankhead, F Berrino, Jackie A Cassell, JMJ Kirwan, K Sikora, M Richards, ML Wynn, MP Coleman, R Horton, R Jones, R Lawrenson, Sarah R Anderson, SW Pascoe, Tarita Murray-Thomas, VL Allgar, VL Allgar, W Hamilton, W Hamilton   +27 more
core   +3 more sources

Cytokine, Chemokine, and Neurofilament Light Chain Signatures in LGI1 Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate the value of cytokine, chemokine, and neurofilament light chain (NfL) concentrations in predicting relapse risk, chronic epilepsy, and functional impairment in LGI1 autoimmune encephalitis (AE). Methods Cytokines/chemokines (IL‐1‐beta, IL‐2, IL‐4, IL‐5, IL‐6, IL‐8/CXCL8, IL‐10, IL‐12p70, IL‐13, IL‐17A, GM‐CSF, TNF ...
Albert Aboseif, Georgios Mangioris, Binxia Yang, Vanessa K. Pazdernik, Jeffrey W. Britton, Divyanshu Dubey, Eoin P. Flanagan, Sarosh R. Irani, Gregory S. Day, Charles L. Howe, A. Sebastian López‐Chiriboga, Andrew McKeon, John R. Mills, Yahel Segal, Michel Toledano, Ivana Vodopivec, Sean J. Pittock, Anastasia Zekeridou   +17 more
wiley   +1 more source

Harnessing Next‐Generation 3D Cancer Models to Elucidate Tumor‐Microbiome Crosstalk

Advanced Healthcare Materials, EarlyView.
Centralizes the microbiome within 3D tumor‐microbiome model platforms, including spheroids, organoids, 3D‐bioprinted constructs, and microfluidic chips, each enabling structured host‐tumor‐microbe studies. These systems support bacterial colonization, facilitating investigation of microbial impacts on tumor growth, immunity, and therapy. The microbiome
Marina Green Buzhor, Giuseppe Longobardi, Or Kandli, Anne Krinsky, Opal Avramoff, Anshika Katyal, Koren Salomon, Adan Miari, Dana Venkert, Tania T. Barnatan, América García Alvarado, Shahar Greenberg, Ronit Satchi‐Fainaro   +12 more
wiley   +1 more source

A prognostic model of patients with ovarian mucinous adenocarcinoma: a population-based analysis

Journal of Ovarian Research, 2022
Background Ovarian mucinous carcinoma is a disease that requires unique treatment. But for a long time, guidelines for ovarian serous carcinoma have been used for the treatment of ovarian mucinous carcinoma.
Li Yang, Jinfen Yu, Shuang Zhang, Yisi Shan, Yajun Li, Liugang Xu, Jinhu Zhang, Jianya Zhang   +7 more
doaj   +1 more source

Molecular analysis of appendiceal mucinous cystadenoma and rectal adenocarcinoma in a patient with urothelial carcinoma: a case report [PDF]

, 2013
Introduction: In this report, we present the case of a patient affected by appendiceal cystadenoma, a colorectal adenocarcinoma, and a concomitant bladder carcinoma, as well as the results of the molecular study of the most relevant mutational pathways ...
Colombino, Maria, Cossu, Antonio, Paliogiannis, Panagiotis, Palmieri, Giuseppe, Pulighe, Fabio, Scognamillo, Fabrizio, Trignano, Mario   +6 more
core   +1 more source

Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis

Advanced Materials, EarlyView.
A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen, Yingjie Fan, Tomas Germanas, Langston Tillman, Jinhong Li, Abigail L. Blenko, Ralph R. Weichselbaum, Wenbin Lin   +7 more
wiley   +1 more source