Results 91 to 100 of about 67,233 (350)

Unraveling the Differences of the Hydrolytic Activity of Trypanosoma cruzi trans-Sialidase and Trypanosoma rangeli Sialidase: A Quantum Mechanics–Molecular Mechanics Modeling Study [PDF]

open access: yes, 2014
Chagas’ disease, also known as American trypanosomiasis, is a lethal, chronic disease that currently affects more than 10 million people in Central and South America. The trans-sialidase from Trypanosoma cruzi (T. cruzi, TcTS) is a crucial enzyme for the
Bueren Calabuig, Juan A.   +2 more
core   +1 more source

Sialic Acid Sensing via Molecularly Imprinted Polymer on Laser‐Induced Graphene

open access: yesAdvanced Sensor Research, EarlyView.
Sialic acid is an important biomarker for oral and overall health. Salivary levels of sialic acid are linked with oral cancer and other diseases. We develop a point‐of‐care sensor for sialic acid, based on molecularly imprinted aminophenylboronic acid electropolymerized onto laser‐induced graphene.
Alexander V. Shokurov   +2 more
wiley   +1 more source

The Interaction of the Gut Microbiota with the Mucus Barrier in Health and Disease in Human

open access: yesMicroorganisms, 2018
Glycoproteins are major players in the mucus protective barrier in the gastrointestinal and other mucosal surfaces. In particular the mucus glycoproteins, or mucins, are responsible for the protective gel barrier.
Anthony P. Corfield
doaj   +1 more source

Pre‐Administration of Akkermansia Muciniphila Prevents the Development of Severe Acute Graft‐Versus‐Host Disease in Systemic Organs

open access: yesAdvanced Science, EarlyView.
Akkermansia muciniphila, a next‐generation probiotic, alleviates acute graft‐versus‐host disease (aGvHD) following allogeneic hematopoietic stem cell transplantation (HSCT) by providing protective effects across multiple organs. Pre‐colonization with A.
Jeong‐Eun Han   +9 more
wiley   +1 more source

Model Systems of Human Intestinal Flora, to Set Acceptable Daily Intakes of Antimicrobial Residues [PDF]

open access: yes, 2000
The veterinary use of antimicrobial drugs in food producing animals may result in residues in food, that might modify the consumer gut flora. This review compares three model systems that maintain a complex flora of human origin: (i) human flora ...
Cemiglia CE   +9 more
core   +2 more sources

Retroperitoneal mucinous cystadenoma

open access: yesEuropean Journal of Obstetrics & Gynecology and Reproductive Biology, 1999
A case of retroperitoneal mucinous cystadenoma histologically confirmed in a 21-year-old woman is reported. Although ultrasound, CT and MR detected the tumor, a preoperative diagnosis could not be established by imaging methods. The cystic tumor was removed and microscopic examination revealed a mucinous cystadenoma. Mullerian mesothelial metaplasia of
Kehagias, DT   +3 more
openaire   +4 more sources

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

open access: yesAdvanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang   +9 more
wiley   +1 more source

A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression. [PDF]

open access: yes, 2017
Metastasis depends upon cancer cell growth and survival within the metastatic niche. Tumors which remodel their glycocalyces, by overexpressing bulky glycoproteins like mucins, exhibit a higher predisposition to metastasize, but the role of mucins in ...
Barnes, J Matthew   +7 more
core   +2 more sources

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression

open access: yesAdvanced Science, EarlyView.
This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li   +12 more
wiley   +1 more source

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