Results 21 to 30 of about 214,902 (267)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Efficacy of 5-ALA Photodynamic Therapy in Dysplastic Oral Leukoplakia: Systematic Review and Meta-Analysis

Pharmaceutics
Background: Oral leukoplakia (OL) with oral epithelial dysplasia (OED) carries an increased risk of malignant transformation and typically requires active management and long-term surveillance.
Magdalena Sulewska, Patryk Wiśniewski, Monika Stępniewska, Zuzanna Poloczek, Dawid Chodziński, Piotr Melion, Maksymilian Pawluczuk, Aleksandra Pietruska, Małgorzata Pietruska   +8 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Platelet-rich fibrin in dentistry

Journal of Applied Biomaterials & Functional Materials
Objectives: To review the progress of Platelet Rich Fibrin (PRF) as a biomaterial in dentistry and to highlight its promising application as a safe and biocompatible autologous platelet concentrate.
Ping Song, Dawei He, Song Ren, Lin Fan, Jiang Sun   +4 more
doaj   +1 more source

Assessment of the effect of the corticotomy-assisted orthodontic treatment on the maxillary periodontal tissue in patients with malocclusions with transverse maxillary deficiency: a case series

BMC Oral Health, 2018
Background The aim of the study was to assess the effect of corticotomy–assisted orthodontic treatment on soft tissue clinical parameters in patients with malocclusions with transverse maxillary deficiency. Methods The study included 20 generally healthy
Magdalena Sulewska, Ewa Duraj, Beata Bugała-Musiatowicz, Emilia Waszkiewicz-Sewastianik, Robert Milewski, Jan K. Pietruski, Eugeniusz Sajewicz, Małgorzata Pietruska   +7 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Efficacy of Photodynamic Therapy With 5-Aminolevulinic Acid-Loaded Oromucosal Emulgel in Patients With Oral Lichen Planus: A Randomized Controlled Clinical Study

International Dental Journal
Introduction and aims: Oral lichen planus (OLP) is a frequently encountered chronic mucosal condition that may predispose individuals to malignant transformations.
Magdalena Sulewska, Aleksandra Pietruska, Jagoda Tomaszuk, Emilia Szymańska, Katarzyna Winnicka, Joanna Narolewska, Małgorzata Pietruska   +6 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Photodynamic therapy in non-surgical treatment of periodontitis

Scientific Reports
Periodontitis is a chronic inflammation disease that, apart from caries, remains the main cause of tooth loss, that lead to a deterioration of the quality of life.
Adrian Maj, Aida Kusiak, Katarzyna Garbacz, Dominika Cichońska, Dariusz Świetlik   +4 more
doaj   +1 more source