Results 11 to 20 of about 5,761 (217)

Beyond the Lung. Impact of Elexacaftor/Tezacaftor/Ivacaftor on Sinonasal Disease in Children With Cystic Fibrosis. [PDF]

Int Forum Allergy Rhinol
ABSTRACT Background Elexacaftor/tezacaftor/ivacaftor (ETI) is a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) therapy that improves pulmonary function and chronic rhinosinusitis (CRS) in cystic fibrosis (CF) adults with at least one copy of the F508del CFTR mutation.
Petitjean M, Letierce A, Bonnel AS, Reix P, Deneuville E, Stremler N, Luscan R, Couloigner V, Mely L, Bessaci K, Labbe G, Marguet C, Kelly-Aubert M, Hassani F, Sermet-Gaudelus I, Simon F, MODUL‐CF Study Group.   +16 more
europepmc   +2 more sources

The Value of Enhancing Sonographic Phenotyping to Improve the Diagnostic Yield of Noninvasive Prenatal Diagnosis (NIPD) for Achondroplasia. [PDF]

Prenat Diagn
ABSTRACT Objectives Achondroplasia is the most common form of skeletal dysplasia and is usually suspected in the third trimester of pregnancy based on abnormal sonographic findings. Non‐invasive prenatal diagnosis (NIPD), based on the detection of pathogenic FGFR3 variants in maternal plasma, provides an accurate genetic confirmation.
Verebi C, Gravrand V, Guerini C, Anselem O, Vaucouleur N, Boimard LO, Ben Ouazzou R, Demirtas C, Leturcq F, Bienvenu T, Tsatsaris V, Pannier E, Nectoux J.   +12 more
europepmc   +2 more sources

Newborn Screening for Cystic Fibrosis Is Associated With the Lowest Healthcare Costs: A 10-Year Observational Follow-Up Study in France. [PDF]

Pediatr Pulmonol
ABSTRACT Objectives This study aims to study the healthcare (HC) costs associated with cystic fibrosis (CF) in children diagnosed prenatally (ANT), through newborn screening (NBS), after birth due to meconium ileus (MI), or later based on symptoms (LS).
Guyot E, Deygas F, Belhassen M, Berard M, Van Ganse E, Sermet-Gaudelus I, Tiaiba S, Dubus JC, Durieu I, Reix P.   +9 more
europepmc   +2 more sources

Rationally Designed InhA Inhibitors: A Comparative Anti-Tubercular Activity Study of Sulfonate Esters of Isoniazid Hydrazones and Their Structurally Flexible Benzyl Analogues. [PDF]

Chem Biol Drug Des
A comparative anti‐tubercular evaluation of sulfonate esters of isoniazid hydrazones and their structurally flexible benzyl analogues disclosed several potent compounds against Mycobacterium tuberculosis with the representative compound displaying an MIC of 0.078 μg/mL.
Kadima MG, Mishra S, Kumar G, Seboletswe P, Roquet-Banères F, Foubert M, Kremer L, Karpoormath R, Singh P.   +8 more
europepmc   +2 more sources

Corrigendum: Long term NIV in an infant with Hallermann-Streiff syndrome: a case report and overview of respiratory morbidity [PDF]

Frontiers in Pediatrics
S. Guerin, S. Blanchon, Q. de Halleux, V. Bayon, T. Ferry   +4 more
doaj   +2 more sources

Rational Design and Antimycobacterial Evaluation of Aryl Sulfonamide-Linked Isoniazid Hydrazones Against Mycobacterium Tuberculosis. [PDF]

ChemMedChem
Molecular docking shows that ligands 8 (a–i) adopt a U‐shaped geometry in the InhA active site, enabling stronger interactions than 7 (j–r). Surprisingly, both sets display similar potency, indicating that factors like electronic effects or solvation also influence anti‐TB activity.
Kadima MG, Mishra S, Kumar G, Seboletswe P, Kajee A, Ankit, Roquet-Banères F, Foubert M, Kremer L, Karpoormath R, Singh P.   +10 more
europepmc   +2 more sources

Lung organoids as a human system for Mycobacteria infection modeling and drug testing. [PDF]

FEBS J
Mycobacterial infections, including tuberculosis (TB) and infections by nontuberculous mycobacteria (NTM), are still public health issues. In 2023, TB caused 1.25 million deaths, while NTM remain a clinical challenge for patients with cystic fibrosis (CF).
Leon-Icaza SA, Vergé R, Mazars R, Berry L, Cougoule C.   +4 more
europepmc   +2 more sources

Estudo da freqüência de diabetes mellitus e intolerância à glicose em pacientes com fibrose cística Study of the frequency of diabetes mellitus and glucose intolerance in patients with cystic fibrosis

Jornal de Pediatria, 2001
OBJETIVO: avaliar a freqüência de diabetes mellitus (DM) e de intolerância à glicose nos pacientes com fibrose cística seguidos no Serviço de Gastropediatria do HC-FMRP-USP.
Flávia A.A. de Castro, Maria I.M. Fernandes, Renan M. Montenegro Júnior, Milton C. Foss   +3 more
doaj   +1 more source

In Vitro Activity of 22 Antibiotics against Achromobacter Isolates from People with Cystic Fibrosis. Are There New Therapeutic Options?

Microorganisms, 2021
Bacteria belonging to the genus Achromobacter are increasingly isolated from respiratory samples of people with cystic fibrosis (PWCF). The management of this multidrug-resistant genus is challenging and characterised by a lack of international ...
Clémence Beauruelle, Claudie Lamoureux, Arsid Mashi, Sophie Ramel, Jean Le Bihan, Thomas Ropars, Anne Dirou, Anandadev Banerjee, Didier Tandé, Hervé Le Bars, Geneviève Héry-Arnaud   +10 more
doaj   +1 more source

Correction to: In vitro prediction of stop-codon suppression by intravenous gentamicin in patients with cystic fibrosis: a pilot study

BMC Medicine, 2018
The original article [1] contains errors in Table 1 affecting some of the presented oligonucleotide sequences and readthrough values in Table 1.
I. Sermet-Gaudelus, M. Renouil, A. Fajac, L. Bidou, B. Parbaille, S. Pierrot, N. Davy, E. Bismuth, P. Reinert, G. Lenoir, J. F. Lesure, J. P. Rousset, A. Edelman   +12 more
doaj   +1 more source