Results 21 to 30 of about 1,531 (166)

In Vitro Activity of 22 Antibiotics against Achromobacter Isolates from People with Cystic Fibrosis. Are There New Therapeutic Options?

Microorganisms, 2021
Bacteria belonging to the genus Achromobacter are increasingly isolated from respiratory samples of people with cystic fibrosis (PWCF). The management of this multidrug-resistant genus is challenging and characterised by a lack of international ...
Clémence Beauruelle, Claudie Lamoureux, Arsid Mashi, Sophie Ramel, Jean Le Bihan, Thomas Ropars, Anne Dirou, Anandadev Banerjee, Didier Tandé, Hervé Le Bars, Geneviève Héry-Arnaud   +10 more
doaj   +1 more source

Rational Design and Antimycobacterial Evaluation of Aryl Sulfonamide-Linked Isoniazid Hydrazones Against Mycobacterium Tuberculosis. [PDF]

ChemMedChem
Molecular docking shows that ligands 8 (a–i) adopt a U‐shaped geometry in the InhA active site, enabling stronger interactions than 7 (j–r). Surprisingly, both sets display similar potency, indicating that factors like electronic effects or solvation also influence anti‐TB activity.
Kadima MG, Mishra S, Kumar G, Seboletswe P, Kajee A, Ankit, Roquet-Banères F, Foubert M, Kremer L, Karpoormath R, Singh P.   +10 more
europepmc   +2 more sources

AVALIAÇÃO POSTURAL COMPUTADORIZADA EM PACIENTES PORTADORES DA FIBROSE CÍSTICA EM UM CENTRO DE REFERÊNCIA EM SALVADOR-BA

Revista Pesquisa em Fisioterapia, 2015
Introdução: A Fibrose Cística (FC) é uma anormalidade genética de caráter sistêmico gerando ao sistema respiratório uma hipersecretividade e obstrução brônquica crônica.
Francisco Oliveira, Cristiane Dias, Anna Lúcia Dinniz, Selena Márcia Dubois Mendes, Abrahão Fontes Baptista, Kátia Nunes Sá   +5 more
doaj   +1 more source

Therapeutic Approaches for Patients with Cystic Fibrosis Not Eligible for Current CFTR Modulators

Cells, 2021
Cystic fibrosis is a severe autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene encoding the CFTR protein, a chloride channel expressed in many epithelial cells.
Isabelle Fajac, Isabelle Sermet
doaj   +1 more source

Lung organoids as a human system for Mycobacteria infection modeling and drug testing. [PDF]

FEBS J
Mycobacterial infections, including tuberculosis (TB) and infections by nontuberculous mycobacteria (NTM), are still public health issues. In 2023, TB caused 1.25 million deaths, while NTM remain a clinical challenge for patients with cystic fibrosis (CF).
Leon-Icaza SA, Vergé R, Mazars R, Berry L, Cougoule C.   +4 more
europepmc   +2 more sources

Quality of care in cystic fibrosis: assessment protocol of the French QIP PHARE-M

Orphanet Journal of Rare Diseases, 2018
Background The PHARE-M care quality improvement program, modeled on the US Cystic Fibrosis Quality Improvement Program, was introduced at 14 cystic fibrosis centers (CFCs) in the French Cystic Fibrosis Network between 2011 and 2013.
Dominique Pougheon Bertrand, Emmanuel Nowak, Clémence Dehillotte, Lydie Lemmonier, Gilles Rault   +4 more
doaj   +1 more source

Early chest CT abnormalities to predict the subsequent occurrence of chronic lung allograft dysfunction

Insights into Imaging, 2023
Introduction Chronic lung allograft dysfunction (CLAD) can take two forms: bronchiolitis obliterans syndrome (BOS) or restrictive allograft syndrome (RAS).
Paul Habert, Elsa Chetrit, Benjamin Coiffard, Fabienne Bregeon, Pascal Thomas, Anderson Loundou, Julien Bermudez, Martine Reynaud-Gaubert, Jean-Yves Gaubert   +8 more
doaj   +1 more source

Putting bicarbonate on the spot: pharmacological insights for CFTR correction in the airway epithelium

Frontiers in Pharmacology, 2023
Introduction: Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) proteins. CFTR controls chloride (Cl−) and bicarbonate (HCO3−) transport into the Airway Surface Liquid (ASL). We investigated the impact
Miroslaw Zajac, Miroslaw Zajac, Miroslaw Zajac, Miroslaw Zajac, Agathe Lepissier, Agathe Lepissier, Agathe Lepissier, Elise Dréano, Elise Dréano, Elise Dréano, Benoit Chevalier, Benoit Chevalier, Benoit Chevalier, Aurélie Hatton, Aurélie Hatton, Aurélie Hatton, Mairead Kelly-Aubert, Mairead Kelly-Aubert, Mairead Kelly-Aubert, Daniela Guidone, Gabrielle Planelles, Aleksander Edelman, Aleksander Edelman, Aleksander Edelman, Emmanuelle Girodon, Emmanuelle Girodon, Alexandre Hinzpeter, Alexandre Hinzpeter, Alexandre Hinzpeter, Gilles Crambert, Iwona Pranke, Iwona Pranke, Iwona Pranke, Luis. J. V. Galietta, Isabelle Sermet-Gaudelus, Isabelle Sermet-Gaudelus, Isabelle Sermet-Gaudelus, Isabelle Sermet-Gaudelus   +37 more
doaj   +1 more source

Role of Host and Bacterial Lipids in Pseudomonas aeruginosa Respiratory Infections

Frontiers in Immunology, 2022
The opportunistic pathogen Pseudomonas aeruginosa is one of the most common agents of respiratory infections and has been associated with high morbidity and mortality rates. The ability of P. aeruginosa to cause severe respiratory infections results from
Pamella Constantino-Teles, Albane Jouault, Lhousseine Touqui, Alessandra Mattos Saliba   +3 more
doaj   +1 more source

Airway Mycobiota-Microbiota During Pulmonary Exacerbation of Cystic Fibrosis Patients: A Culture and Targeted Sequencing Study. [PDF]

Mycoses
ABSTRACT Background The airways of patients with cystic fibrosis (pwCF) harbour complex fungal and bacterial microbiota involved in pulmonary exacerbations (PEx) and requiring antimicrobial treatment. Descriptive studies analysing bacterial and fungal microbiota concomitantly are scarce, especially using both culture and high‐throughput‐sequencing (HTS)
Angebault C, Vandenborght LE, Bassinet L, Wizla N, Ferroni A, Dessein R, Remus N, Thumerelle C, Fauchet N, Epaud R, Delhaes L, Botterel F.   +11 more
europepmc   +2 more sources