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MBRA 3.0: integrating the mucus environment for advanced high-throughput in vitro intestinal microbiome modeling [PDF]
Gut MicrobesThe colonic mucus layer is a dynamic barrier that plays central roles in intestinal health, and recent studies highlight that it harbors a distinct and functionally critical microbial community. However, most in vitro gut models fail to recapitulate this
Maeva Duquesnoy, Benoit Chassaing
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Current Biology, 2021 Mucus is a slimy hydrogel that lines the mucosal surfaces in our body, including the intestines, stomach, eyes, lungs and urogenital tract. This glycoprotein-rich network is truly the jack of all trades. As a barrier, it lubricates surfaces, protects our cells from physical stress, and selectively allows the passage of nutrients while clearing out ...
McShane, Abigail +7 more
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Intestinal mucin-type O-glycans: the major players in the host-bacteria-rotavirus interactions
Gut Microbes, 2023 Rotavirus (RV) causes severe diarrhea in young children and animals worldwide. Several glycans terminating in sialic acids (SAs) and histo-blood group antigens (HBGAs) on intestinal epithelial cell (IEC) surface have been recognized to act as attachment ...
S.A. Raev +3 more
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Microorganisms, 2023 The gastric pathogen, Helicobacter pylori bacteria have to swim across a pH gradient from 2 to 7 in the mucus layer to colonize the gastric epithelium. Previous studies from our group have shown that porcine gastric mucin (PGM) gels at an acidic pH < 4 ...
Clover Su-Arcaro +6 more
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Health Science Reports, 2022 Background and Aims In cystic fibrosis (CF) airways, impaired airway mucociliary clearance and mucus accumulation due to cystic fibrosis transmembrane conductance regulator defects contribute to inflammation, progressive structural lung damage, and ...
Hanna Schmidt +5 more
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Frontiers in Plant Science, 2021 The beneficial health of evaluating prebiotic effect by the consumption of Agave salmiana fructans (A. salmiana fructans) was assessed in the epithelium of the cecum and proximal colon of Wistar rats fed at different doses for 35 days with regards to ...
Amneris Iraida Castillo Andrade +5 more
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Characterization of Highly Mucus-Adherent Non-GMO Derivatives of Lacticaseibacillus rhamnosus GG
Frontiers in Bioengineering and Biotechnology, 2020 Lacticaseibacillus rhamnosus GG is one of the best studied lactic acid bacteria in the context of probiotic effects. L. rhamnosus GG has been shown to prevent diarrhea in children and adults and has been implicated to have mitigating or preventive ...
Pia Rasinkangas +9 more
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Biology, 2021 Mucociliary defense, mediated by the ciliated and goblet cells, is fundamental to respiratory fitness. The concerted action of ciliary movement on the respiratory epithelial surface and the pathogen entrapment function of mucus help to maintain healthy ...
Adivitiya +4 more
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Diversity, 2022 The importance of mucus produced by jellyfish species remains as understudied as their feeding behavior. Here, we study medusae under captivity, ascertain the role of mucus, and describe its feeding behavior.
Alicia Verónica Camacho-Pacheco +5 more
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Phage-encoded carbohydrate-interacting proteins in the human gut
Frontiers in Microbiology, 2023 In the human gastrointestinal tract, the gut mucosa and the bacterial component of the microbiota interact and modulate each other to accomplish a variety of critical functions.
Daniela Rothschild-Rodriguez +4 more
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