Results 11 to 20 of about 388,969 (398)

Tezepelumab and Mucus Plugs in Patients with Moderate-to-Severe Asthma.

NEJM Evidence, 2023
Tezepelumab and Mucus Plugs in Patients with AsthmaMucus plugs in airways of asthma patients are associated with airway obstruction and the activity of inflammatory cytokines.
L. Nordenmark, A. Hellqvist, Claire Emson, S. Diver, C. Porsbjerg, J. Griffiths, John D Newell, Samuel Peterson, Beata Pawlikowska, J. R. Parnes, A. Megally, G. Colice, Christopher E. Brightling   +12 more
semanticscholar   +1 more source

An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function

Science, 2021
Goblet cell diversity An adult human has a gut surface area averaging 30 square meters that is bombarded daily by xenobiotics and microorganisms. Mucus synthesized by goblet cells supplies a protective barrier coating. Nyström et al.
Elisabeth E. L. Nyström, B. Martinez-Abad, L. Arike, G. Birchenough, Eric B. Nonnecke, P. A. Castillo, Frida Svensson, C. Bevins, G. Hansson, M. Johansson   +9 more
semanticscholar   +1 more source

Short‐term effects of a novel bronchial drainage device: A pilot cohort study in subjects with cystic fibrosis

Health Science Reports, 2022
Background and Aims In cystic fibrosis (CF) airways, impaired airway mucociliary clearance and mucus accumulation due to cystic fibrosis transmembrane conductance regulator defects contribute to inflammation, progressive structural lung damage, and ...
Hanna Schmidt, Monika Toth, Christine Kappler‐Schorn, Ute Siebeneich, Sebastian F. N. Bode, Dorit Fabricius   +5 more
doaj   +1 more source

Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems

Journal of Nanobiotechnology, 2022
Oral delivery of therapeutics is the preferred route of administration due to ease of administration which is associated with greater patient medication adherence.
Deepak A. Subramanian, R. Langer, G. Traverso   +2 more
semanticscholar   +1 more source

Mucociliary Respiratory Epithelium Integrity in Molecular Defense and Susceptibility to Pulmonary Viral Infections

Biology, 2021
Mucociliary defense, mediated by the ciliated and goblet cells, is fundamental to respiratory fitness. The concerted action of ciliary movement on the respiratory epithelial surface and the pathogen entrapment function of mucus help to maintain healthy ...
Adivitiya, Manish Singh Kaushik, Soura Chakraborty, Shobi Veleri, Suneel Kateriya   +4 more
doaj   +1 more source

Autophagy controls mucus secretion from intestinal goblet cells by alleviating ER stress

bioRxiv, 2022
Colonic goblet cells are specialized epithelial cells that secrete mucus to form a barrier between the host and its microbiota, thus preventing bacterial invasion and inflammation. How goblet cells control the amount of mucus they secrete is unclear.
Maria Naama, Shahar Telpaz, Aya Awad, Shira Ben-Simon, Sarina Harshuk-Shabso, Sonia Modilevsky, Elad Rubin, Jasmin Sawaed, Lilach Zelik, Mor Zigdon, Nofar Fadida, S. Turjeman, M. Werbner, S. Wongkuna, B. Schroeder, A. Nyska, M. Nuriel-Ohayon, Shai Bel   +17 more
semanticscholar   +1 more source

Leveraging 3D Model Systems to Understand Viral Interactions with the Respiratory Mucosa

Viruses, 2020
Respiratory viruses remain a significant cause of morbidity and mortality in the human population, underscoring the importance of ongoing basic research into virus–host interactions.
Ethan Iverson, Logan Kaler, Eva L. Agostino, Daniel Song, Gregg A. Duncan, Margaret A. Scull   +5 more
doaj   +1 more source

Prebiotic oligofructose protects against high-fat diet-induced obesity by changing the gut microbiota, intestinal mucus production, glycosylation and secretion

Gut microbes, 2022
Obesity is a major risk factor for the development of type 2 diabetes and cardiovascular diseases, and gut microbiota plays a key role in influencing the host energy homeostasis.
P. Paone, Francesco Suriano, C. Jian, K. Korpela, N. Delzenne, M. Van Hul, A. Salonen, Patrice D Cani   +7 more
semanticscholar   +1 more source

Lactobacillus reuteri inhibition of Enteropathogenic Escherichia coli adherence to human intestinal epithelium [PDF]

, 2016
Enteropathogenic Escherichia coli (EPEC) is a major cause of diarrheal infant death in developing countries, and probiotic bacteria have been shown to provide health benefits in gastrointestinal infections.
Bartman, Bernet, Bray, Casas, De Keersmaecker, Etzold, Etzold, Etzold, Forestier, Frese, Havenaar, Jensen, Johansson, Juge, Kim, Knutton, Lanata, Lebeer, Levine, MacKenzie, Miyoshi, Moon, Nataro, Navabi, Ogawa, Oh, Ouwehand, Roos, Savino, Sazawal, Schüller, Servin, Sheng, Sherman, Shornikova, Shornikova, Szajewska, Talarico, Tuomola, Valeur, van Klinken, Viswanathan, Wong   +42 more
core   +5 more sources

Cervicovaginal mucus barrier properties during pregnancy are impacted by the vaginal microbiome

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionMucus in the female reproductive tract acts as a barrier that traps and eliminates pathogens and foreign particles via steric and adhesive interactions.
Hannah C. Zierden, Hannah C. Zierden, Kevin DeLong, Kevin DeLong, Fareeha Zulfiqar, Fareeha Zulfiqar, Jairo Ortiz Ortiz, Jairo Ortiz Ortiz, Victoria Laney, Victoria Laney, Sabrine Bensouda, Sabrine Bensouda, Nicole Hernández, Nicole Hernández, Thuy M. Hoang, Thuy M. Hoang, Samuel K. Lai, Justin Hanes, Justin Hanes, Justin Hanes, Justin Hanes, Justin Hanes, Anne E. Burke, Laura M. Ensign, Laura M. Ensign, Laura M. Ensign, Laura M. Ensign, Laura M. Ensign, Laura M. Ensign   +28 more
doaj   +1 more source