Incorporating a mucosal environment in a dynamic gut model results in a more representative colonization by lactobacilli [PDF]
, 2011 To avoid detrimental interactions with intestinal microbes, the human epithelium is covered with a protective mucus layer that traps host defence molecules. Microbial properties such as adhesion to mucus further result in a unique mucosal microbiota with
Derde, Melanie +10 more
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Disease Models & Mechanisms, 2022 The gut microbiota plays a crucial role in protecting against enteric infection. However, the underlying mechanisms are largely unknown owing to a lack of suitable experimental models.
Conor J. McGrath +5 more
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Mucus, commensals, and the immune system
Gut microbes, 2022 The immune system in the large intestine is separated from commensal microbes and comparatively rare enteric pathogens by a monolayer of diverse epithelial cells overlaid with a compact and adherent inner mucus layer and a looser outer mucus layer ...
Qing Zhao, Craig L. Maynard
semanticscholar +1 more source
Arabinoxylans, inulin and Lactobacillus reuteri 1063 repress the adherent-invasive Escherichia coli from mucus in a musosa-comprising gut model [PDF]
, 2016 The microbiota that colonises the intestinal mucus may particularly affect human health given its proximity to the epithelium. For instance, the presence of the adherent-invasive Escherichia coli (AIEC) in this mucosal microbiota has been correlated with
De Weirdt, Rosemarie +6 more
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Alpha-tocopherol exerts protective function against the mucotoxicity of particulate matter in amphibian and human goblet cells [PDF]
, 2020 Exposure to particulate matter (PM) in ambient air is known to increase the risk of cardiovascular disorders and mortality. The cytotoxicity of PM is mainly due to the abnormal increase of reactive oxygen species (ROS), which damage cellular components ...
Bang, Woo Young +7 more
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Development and Functional Properties of Intestinal Mucus Layer in Poultry
Frontiers in Immunology, 2021 Intestinal mucus plays important roles in protecting the epithelial surfaces against pathogens, supporting the colonization with commensal bacteria, maintaining an appropriate environment for digestion, as well as facilitating nutrient transport from the
Yada Duangnumsawang +2 more
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Using Serious Games to Motivate Children with Cystic Fibrosis to Engage with Mucus Clearance Physiotherapy [PDF]
, 2012 Positive expiratory pressure (PEP) therapy is an effective method for removing mucus build-up in the lungs of sufferers of chronic lung diseases such as cystic fibrosis (CF).
Day, David, Oikonomou, Andreas
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Mucus-Inspired Dynamic Hydrogels: Synthesis and Future Perspectives
Journal of the American Chemical Society, 2022 Mucus hydrogels at biointerfaces are crucial for protecting against foreign pathogens and for the biological functions of the underlying cells. Since mucus can bind to and host both viruses and bacteria, establishing a synthetic model system that can ...
Raju Bej, R. Haag
semanticscholar +1 more source
The Interaction of the Gut Microbiota with the Mucus Barrier in Health and Disease in Human
Microorganisms, 2018 Glycoproteins are major players in the mucus protective barrier in the gastrointestinal and other mucosal surfaces. In particular the mucus glycoproteins, or mucins, are responsible for the protective gel barrier.
Anthony P. Corfield
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Frontiers in Physiology, 2018 Mucus is a major component of the intestinal barrier involved both in the protection of the host and the fitness of commensals of the gut. Streptococcus thermophilus is consumed world-wide in fermented dairy products and is also recognized as a probiotic,
Neïké Fernandez +24 more
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