Results 31 to 40 of about 178,661 (314)

The gut wall provides an effective barrier against nanoparticle uptake

Beilstein Journal of Nanotechnology, 2014
Background: The omnipresence of nanoparticles (NPs) in numerous goods has led to a constant risk of exposure and inadvertent uptake for humans. This situation calls for thorough investigation of the consequences of NP intake.
Heike Sinnecker, Thorsten Krause, Sabine Koelling, Ingmar Lautenschläger, Andreas Frey   +4 more
doaj   +1 more source

Efeito do etanol e do peróxido de hidrogênio intragástrico sobre a mucosa gástrica de rã (Rana catesbeiana, SHAW) Effect of intragastric ethanol and hydrogen peroxide in frog gastric mucosa (Rana catesbeiana, SHAW)

Brazilian Archives of Biology and Technology, 1998
This work investigated the frog gastric mucosa response to hydrogen peroxide and ethanol induced injury. Acid and mucus secretion were estimated "in vitro" in control animals with intragastric absolute ethanol (1ml/30min.
Hidê Virgínia Estivallet, Maria Inês Rodrigues, Norma Possa Marroni   +2 more
doaj   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Enhancing Mucus Flow and Clearance by Grafting Zwitterionic Hydrogel Films to Luminal Surfaces

Laryngoscope Investigative Otolaryngology
Objective To determine the effects of zwitterionic hydrogel films on mucus contact angles, flow, and stasis with respect to medical polymer surfaces, both flat and tubular.
Ryan Horne, Caleb Escudero, Morgan Ellerman, C. Allan Guymon, Marlan Hansen   +4 more
doaj   +1 more source

Carbon Dots with Tunable Charge as Mucus-Penetrating Gene Carriers

Pharmaceutics
Background/Objectives: Local delivery of gene therapy products through the airways shows great promise for the treatment of a number of serious lung diseases, but its effectiveness is hampered by the mucus layer protecting the lung epithelium in the ...
Samuel Arca, Clea Witjaksono, Françoise Pons, Luc Lebeau   +3 more
doaj   +1 more source

Niflumic Acid Reverses Airway Mucus Excess and Improves Survival in the Rat Model of Steroid-Induced Pneumocystis Pneumonia

Frontiers in Microbiology, 2019
Although the role of adaptive immunity in fighting Pneumocystis infection is well known, the role of the innate, airway epithelium, responses remains largely unexplored.
Francisco J. Pérez, Pablo A. Iturra, Carolina A. Ponce, Fabien Magne, Víctor Garcia-Angulo, Sergio L. Vargas   +5 more
doaj   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Computational modeling of cough-induced droplets and mucosal film dynamics in the upper airway for pulmonary disease classification

Frontiers in Physiology
IntroductionCough-generated droplets are critical in the transmission and progression of respiratory diseases. This study investigates droplet formation and transport in the upper airway during a cough to improve understanding of their biomechanical ...
Olusegun J. Ilegbusi, Rafid Jahangir Khan, Bari Hoffman, Bari Hoffman   +3 more
doaj   +1 more source

Spleen‐Targeting Biomimetic Hybrid Nanocarriers for Systemic Immune Reprogramming in Colitis: RBC Membrane Vesicle‐Fused Lipid Nanoparticles

Advanced Functional Materials, EarlyView.
A spleen‐targeting hybrid nanoplatform (RBCMV‐LNP‐RP) harnessing erythrophagocytosis mimics senescent red blood cell clearance to achieve spleen‐specific delivery of rapamycin. This biomimetic system enables selective accumulation in splenic macrophages, orchestrating systemic immune reprogramming and promoting mucosal healing in an inflammatory bowel ...
Jun Kwon, Hee Su Sohn, Jong Sang Yoon, So Won Jeon, Hee Gyeong Ko, Min‐Ho Kang, Jisun Lee, Jae‐Hwan Nam, Louis T. Merriam, Edy Y. Kim, Han Young Kim   +10 more
wiley   +1 more source

MUCOLYTIC ACTIVITY OF ROSELLE (Hibiscus sabdariffa L.) CALYCES EXTRACT ON COW INTESTINAL MUCUS

Jurnal Kedokteran Hewan, 2018
This study aimed to examine the mucolytic activity of roselle calyces extract on cow intestinal mucus in vitro. The extraction of roselle calyces was performed by the subsequence maceration method using different polarity solvent (n-hexane, ethyl acetate,
Nerdy Nerdy, Kesaktian Manurung
doaj   +1 more source