Results 91 to 100 of about 108,258 (290)

A novel mouse model of chronic Pseudomonas aeruginosa infection inducing bronchiectasis‐like phenotype

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This graphical abstract highlights a bronchiectasis mouse model driven by chronic Pseudomonas aeruginosa (CPA)‐loaded agar beads plus papain, which reproduces significant airway structural damage, inflammation, mucous overproduction, and functional impairment, providing a clinically relevant platform for studying disease mechanisms and evaluating ...
Heng Yang   +11 more
wiley   +1 more source

The biochemical and molecular characterisation of respiratory mucins in TB

open access: yes, 2006
Includes bibliographical references (leaves 96-112).The role of the dominant respiratory mucins (MUC5AC and MUC5B) and MUC2 has been investigated in chronic airway diseases as it is the mucin glycoprotein that confers upon mucus its biological ...
Govender, Ureshnie
core  

An artificial mucus-integrated in vitro model enables stable live probiotic–host co-culture and recapitulates dynamic hBD-2-mediated antimicrobial feedback

open access: yesGut Microbes Reports
In vitro models for host–microbe interaction often have limited physiological relevance due to the absence of a protective mucus layer, reliance on non-viable bacteria, and short co-culture durations. Here, we present the first scalable and biocompatible
Wenxin Cao   +4 more
doaj   +1 more source

Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic Activity

open access: yesEBioMedicine, 2018
Many epithelial surfaces of the body are covered with protective mucus, and disrupted mucus homeostasis is coupled to diseases such as ulcerative colitis, helminth infection, cystic fibrosis, and chronic obstructive lung disease. However, little is known
Elisabeth E.L. Nyström   +6 more
doaj   +1 more source

Characterization of the extracellular matrix from human and dog umbilical cords

open access: yesThe Anatomical Record, EarlyView.
Abstract The extracellular matrix is important for maintaining tissue morphogenesis and homeostasis; it can also be used as a biomaterial for the production of biological scaffolds. Particularly, the umbilical cord has shown potential in the production of scaffolds for small‐diameter vessels.
Ana Carla Mendonça   +6 more
wiley   +1 more source

Coupled secretion of chloride and mucus in skin of Xenopus laevis: possible role for CFTR

open access: yes, 1994
We used the isolated skin of Xenopus laevis to investigate the relationship between the secretion of salt, water, and mucus by submucosal glands expressing the cystic fibrosis transmembrane conductance regulator (CFTR).
E. Allen   +5 more
core   +1 more source

Mucus glycoprotein secretion by tracheal explants: effects of pollutants. [PDF]

open access: yes, 1980
Tracheal slices incubated with radioactive precursors in tissue culture medium secrete labeled mucus glycoproteins into the culture medium. We have used an in vivtro approach, a combined method utilizing exposure to pneumotoxins in vivo coupled with ...
T Kaizu, J A Last, Last, JA, Kaizu, T
core   +1 more source

Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases

open access: yesMediators of Inflammation, 2015
Chloride transport proteins play critical roles in inflammatory airway diseases, contributing to the detrimental aspects of mucus overproduction, mucus secretion, and airway constriction.
Monica Sala-Rabanal   +3 more
doaj   +1 more source

Innervation of the tubarial glands: A hypothesis‐driven anatomical review

open access: yesThe Anatomical Record, EarlyView.
Abstract The tubarial glands have been described as a macroscopic bilateral glandular complex in the posterolateral nasopharynx near the torus tubarius and the pharyngeal opening of the Eustachian tube. Since their recognition on prostate‐specific membrane antigen‐based imaging, their anatomical classification has remained debated, with converging ...
Mugurel Constantin Rusu   +2 more
wiley   +1 more source

Developmental morphology of claspers and clasper‐glands during maturation in Potamotrygon wallacei (Chondrichthyes: Potamotrygoninae)

open access: yesThe Anatomical Record, EarlyView.
Abstract The claspers are the copulatory organs in male elasmobranchs, responsible for directing the semen into the female cloaca (C). However, the microscopic morphology of the claspers remains poorly understood. This study describes the morphology of the claspers and clasper glands (CGs) of cururu stingray (Potamotrygon wallacei) at different ...
Matheus Samuel Cunha Braga   +4 more
wiley   +1 more source

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